Aa
Research supported antifibrotics - do they exist?
The problems of treatment failure for SOC/IFN nonresponders and the possibility of reducing future supercombo-SVRchances by introducing archived resistance mutations when using "Pseudomonotherapy" - (that is here defined as using a single antiviral agent that is not protected against resistance development by its combo with an IFN/riba component (IFN by definition in this scenario is not sufficiently effective in reducing viral replication so that all the burden to tame the adaptive quasispecies evolution falls on the antiviral)) together with the 61% and 65% SVR rates for the latest triple modality in Geno 1s, have raised concern and the awareness for the need for alternate/additional treatment modalities in many HCV patients and their health care providers. Waiting for future antiviral developments is one route frequently recommended, but for the patients in current need, our repertoire of additional meaningful approaches needs to be carefully reevaluated. Using antifibrotics to halt fibrosis progression is one concept not proven in large trials but it might well be effective in many, because the mechanisms for fibrosis generation are not intrinsically linked to HCV persistence, but rather to secondary response mechanisms evoked in the chronically inflamed liver, with the stellate cell activation holding center stage in this scenario. The following is one of several possible add on modalities.
thank you for your response. yes i perceived you were hesitant and i really appreciate you giving the information. it will save alot of $ and frustration finding the best products.
to answer your question. no. they should not be excluded from presenting or medical opinion forming.
we pay our physcians well and i have high regard for their educated opinions, as i have for yours.
it is strange to me that others contribute motives to my question, as if i crossed over some invisible line when i feel comfortable with such questions and not out of the norm. i perceive also indignation at such a question. the response is always interesting and revealing.
best regards
to answer your question. no. they should not be excluded from presenting or medical opinion forming.
we pay our physcians well and i have high regard for their educated opinions, as i have for yours.
it is strange to me that others contribute motives to my question, as if i crossed over some invisible line when i feel comfortable with such questions and not out of the norm. i perceive also indignation at such a question. the response is always interesting and revealing.
best regards
MEDICAL PROFESSIONAL
I have absolutely none financial interest in any of these compounds or any, even the slightest connection with any of these companies that sell them. For some specific products i haven taken the time to investigate brand specifics with respect to purity, quality control and content, because there are big problems with many of these If you carefully read this thread, you will see that I was hesitant to give out any brand names, but the confusion of this PPC with Cholin and lecithin made it necessary so that some who might want to try this, can actually proceed and will not waste their energy in the wrong direction.
BTW all the panelists/hepatologists in the top level discussions in the satellite meetings and the presentations have heavy financial interest/are beeing compensated by the pharmaceutical industry.
They have to disclose that now at the beginning of these discussions/presentations. Should they be excluded from presenting or medical community opinion forming?
How long would a meaningful discussion have to be to cover the deep problems, but also the importance of development of effective medicines powered by the drive of these investors/stockholders/executives? I cannot participate in these questions, since that takes real time and it takes real time to work on a knowledge base necessary to optimize the approach to these burning real life biology/medical questions that surround the treatment of Hepatis B and C and fibrosis progression..
BTW all the panelists/hepatologists in the top level discussions in the satellite meetings and the presentations have heavy financial interest/are beeing compensated by the pharmaceutical industry.
They have to disclose that now at the beginning of these discussions/presentations. Should they be excluded from presenting or medical community opinion forming?
How long would a meaningful discussion have to be to cover the deep problems, but also the importance of development of effective medicines powered by the drive of these investors/stockholders/executives? I cannot participate in these questions, since that takes real time and it takes real time to work on a knowledge base necessary to optimize the approach to these burning real life biology/medical questions that surround the treatment of Hepatis B and C and fibrosis progression..
T'hassee: Unsaturated fats also have a more enlarged shape than saturated fats.
So that would explain what I was seeing at the beach all summer....
Thanks!!!!! That was a great chemistry lesson!
So that would explain what I was seeing at the beach all summer....
Thanks!!!!! That was a great chemistry lesson!
I guess, in life, if you hold somebody with two hands -- the union should be stronger :-)
But in organic chemistry -- the second double hand "just looking for a trouble" to get attached to something. :-)
But in organic chemistry -- the second double hand "just looking for a trouble" to get attached to something. :-)
"See, you are holding two people with TWO hands --- you entered UNSATURATED state"
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Should read: See, you are holding two people with TWO hands for each person (using all 4 of your hands for only two people) --- you entered UNSATURATED state .
________________________________________________________________________
Should read: See, you are holding two people with TWO hands for each person (using all 4 of your hands for only two people) --- you entered UNSATURATED state .
A fatty acid molecule is monounsaturated if it contains one double bond, and polyunsaturated if it contains more than one double bond.
In simple terms: Imagine that you have four (4) arms (just like every carbon molecule, and carbon molecules are like a back bone for all organic matters).
Having 4 arms, you may hold 4 different people simultaneously with your hands -- this will be your "SATURATED" state, because you used up all your arms and can't possible to add any other person (or a chemical substance, for example, oxygen or hydrogen) to be held.
Now imagine that two persons left you and now you have two "free" hands. Remember, you have a total of four arms (hands). So, instead of acquiring other new people (or chemical) for "holding time", you chose to use two hands simultaneously to hold two remaining people (who happened to be happy to be with you :-)
See, you are holding two people with TWO hands --- you entered UNSATURATED state -- why? -- because at any given moment, if conditions are right, you may change your mind and grab "passing by" molecules of OXYGEN (for example) with your "double bonded" hands, without losing your original devoted two people (chemically speaking, without breaking your structure, or backbone).
Unsaturated fats have these "double" bonded connections - hands; thus making a molecule potentially chemically more active – at any given moment - let say olive oil exposed to heat -- and boom -- unsaturated fats became saturated with oxygen and looses its "healthfullness".
If fatty acid's molecule has one double bond -- it will be called monounsaturated fat. If it has two or more double bonds - it will be called polyunsaturated fat. As you can see, than more double bonds, than more likely a molecule will be more chemically active -- either it will be a protection from free radicals, or its ability to enter cell membrane to re-establish original cell structure,... or rebuild cells,... or just participate in the endless process of so needed bio-chemicals production (in this PPC's case --- for production of S-Adenosyl-Methionine, as one of the substances).
I hope this makes sense. English is not my first language, I think I was lost in the midst of my "holding hands" metaphor.
If it is still does not make any sense, I will try later again :-)
But anyway, if one product has 21% of polyunsaturated fats and the other has "up" to 70%, I would like to know from what exactly "up" starts :-)
All the best!
Where double bonds are formed, hydrogen atoms are eliminated. Thus, a saturated fat is "saturated" with hydrogen atoms. In cellular metabolism hydrogen-carbon bonds are broken down - or oxidized - to produce energy, thus an unsaturated fat molecule contains somewhat less energy (i.e fewer calories) than a comparable sized saturated fat. The greater the degree of unsaturation in a fatty acid (ie, the more double bonds in the fatty acid), the more vulnerable it is to lipid peroxidation (rancidity). Antioxidants can protect unsaturated fat from lipid peroxidation. Unsaturated fats also have a more enlarged shape than saturated fats.
In simple terms: Imagine that you have four (4) arms (just like every carbon molecule, and carbon molecules are like a back bone for all organic matters).
Having 4 arms, you may hold 4 different people simultaneously with your hands -- this will be your "SATURATED" state, because you used up all your arms and can't possible to add any other person (or a chemical substance, for example, oxygen or hydrogen) to be held.
Now imagine that two persons left you and now you have two "free" hands. Remember, you have a total of four arms (hands). So, instead of acquiring other new people (or chemical) for "holding time", you chose to use two hands simultaneously to hold two remaining people (who happened to be happy to be with you :-)
See, you are holding two people with TWO hands --- you entered UNSATURATED state -- why? -- because at any given moment, if conditions are right, you may change your mind and grab "passing by" molecules of OXYGEN (for example) with your "double bonded" hands, without losing your original devoted two people (chemically speaking, without breaking your structure, or backbone).
Unsaturated fats have these "double" bonded connections - hands; thus making a molecule potentially chemically more active – at any given moment - let say olive oil exposed to heat -- and boom -- unsaturated fats became saturated with oxygen and looses its "healthfullness".
If fatty acid's molecule has one double bond -- it will be called monounsaturated fat. If it has two or more double bonds - it will be called polyunsaturated fat. As you can see, than more double bonds, than more likely a molecule will be more chemically active -- either it will be a protection from free radicals, or its ability to enter cell membrane to re-establish original cell structure,... or rebuild cells,... or just participate in the endless process of so needed bio-chemicals production (in this PPC's case --- for production of S-Adenosyl-Methionine, as one of the substances).
I hope this makes sense. English is not my first language, I think I was lost in the midst of my "holding hands" metaphor.
If it is still does not make any sense, I will try later again :-)
But anyway, if one product has 21% of polyunsaturated fats and the other has "up" to 70%, I would like to know from what exactly "up" starts :-)
All the best!
Where double bonds are formed, hydrogen atoms are eliminated. Thus, a saturated fat is "saturated" with hydrogen atoms. In cellular metabolism hydrogen-carbon bonds are broken down - or oxidized - to produce energy, thus an unsaturated fat molecule contains somewhat less energy (i.e fewer calories) than a comparable sized saturated fat. The greater the degree of unsaturation in a fatty acid (ie, the more double bonds in the fatty acid), the more vulnerable it is to lipid peroxidation (rancidity). Antioxidants can protect unsaturated fat from lipid peroxidation. Unsaturated fats also have a more enlarged shape than saturated fats.
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