Research supported antifibrotics - do they exist?

[Hepatitis Researcher]

The problems of treatment failure for SOC/IFN nonresponders and the possibility of reducing future supercombo-SVRchances by introducing archived resistance mutations when using "Pseudomonotherapy" - (that is here defined as using  a single  antiviral agent that is not protected against resistance development by its combo with an IFN/riba component (IFN by definition in this scenario is not sufficiently effective in reducing viral replication so that all the burden to tame the adaptive quasispecies evolution falls on the antiviral)) together with the 61% and 65% SVR rates for the latest triple modality in Geno 1s, have raised concern and the awareness for the need for alternate/additional treatment modalities in many HCV patients and their health care providers. Waiting for future antiviral developments is one route frequently recommended, but for the patients  in current need, our repertoire of additional meaningful approaches needs to be carefully reevaluated. Using antifibrotics to halt fibrosis progression is one concept not proven in large trials but it might well be effective in many, because the mechanisms for fibrosis generation are not intrinsically linked to HCV persistence, but rather to secondary response mechanisms evoked in the chronically inflamed liver, with the stellate cell activation holding center stage in this scenario. The following is one of several possible add on modalities.

[Whrose]

i am curious and must ask. do you have a financial interest the mentioned compound?
thank you

[drofi]

Good morning,

I am far away to tell that mp-1021 has a proven effect.

But please don't mix it, you still did not tell any data for the more interesting question:

Quote: "To get a good feel for the overall effect, you need to study many publications in its regard"

I would love to study many publications in its regard and would love to get links to better publications about human trials with PPC, than the one I have posted.

As you know the opinionleaders here in Germany want evidence based data. They will not accept as an argument, if I tell them that a very clever guy in a forum told us that he has this opinion :-)

Here is the question again:
Any links to good human trials about PPC and fibrosis available? Any human efficacy trials for PPC available?

Thank you in advance, drofi

[CockSparrow]

Whrose - do you have a financial interest the mentioned compound
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I cant believe you asked that question.
CS

[drofi]

Quote: "To be sarcastic, in Germany the  HCV standard therapy apparently consists already of nucleosidanalogs"

Yes, it does. IFN and RIBAVIRIN.
Didn't you know that Ribavirin is a nucleosidanalog?
http://en.wikipedia.org/wiki/Ribavirin

[Whrose]

sorry. i believe it is a legitimate question. afterall docs have no problem in the medical forum with such disclosures, and should not here. it is an honest question. if the science supports this product i am very interested in it and so would many hepatologist! i respect HR and his kindness to come and talk with us and am grateful. i have learned from him and others in some cool discussions.

[evangelin]

I just can't thank you enough for taking your valuable time to help us with this information.  My husband is a twice non responder with cirrhosis. I know you aren't God and you can't know for sure it
will help, but your guesses are a whole lot better than mine.  I greatly appreciate your help.  
God bless you for this sacrificial use of your time.