Aa
Saw on CNN a report that said transmission from mother to girls much higher
Strange.
Mother to child transmission of hep-c occurs significantly more often among girls than among boys. Results of a large european study Go figure.
Ron
Mother to child transmission of hep-c occurs significantly more often among girls than among boys. Results of a large european study Go figure.
Ron
I am almost 120 lbs at 5ft 7 and on 1,000 instead of the lower dosage of 800 (I listned to Jim and am glad I DID argue with the Dr. to up my Riba).
I think upping tremendously as jim does is courageous and I know I couldn't handle THAT but upping the one pill so far seems to have helped me AMAZINGLY. As a 1A and 1B I know it's harder to achieve SVR but I am going towards it big time.
I did have horrific problems with the anemia BUT the Epogen fixed it lickity split and now I am fine.
I think upping tremendously as jim does is courageous and I know I couldn't handle THAT but upping the one pill so far seems to have helped me AMAZINGLY. As a 1A and 1B I know it's harder to achieve SVR but I am going towards it big time.
I did have horrific problems with the anemia BUT the Epogen fixed it lickity split and now I am fine.
I weigh 170lbs and I'm on 1200ml riba. If you get the 4-wk pcr and are not happy with the progress, you could up the riba then. Provided you and your blood counts can handle it. That would give you a booster until you get your 12-wk pcr.I have heard of people in the low 200's on 1400 and 1600 ml of riba. Peace
Half doses of Peg alone, NO RIBA...
The theory is to keep the VL undetectable, and letting the liver regenerate.. In my honest opinion, I believe that she thinks I will relapse, and thus her reasoning for maintenace..
But this is why I went in search of answers from various Dr's, and ended up in Schiff's office.
For me, Maintanece was not the answer, as on the meds, my ALT's where still elevated. So my liver was not getting a break so to speak. One of the Dr's I consulted with even suggested that the elevation in ALT's was the regeneration of the liver, and the destruction and dying off of prior scar tissue. That this was a newly thought theory going around the medical community at the time, and some what substantiated by the Fibroscan results towards the latter part of my tx.
Tx is such a "security" blanket for us, it is hard to throw in the towel. We may complain and whine the whole way through, but when it comes time to end it, it is HARD to let go. Sometimes you just have to roll and dice and play the odds.
Good luck with whatever you do, and keep checking that pulse!!! LOL
The theory is to keep the VL undetectable, and letting the liver regenerate.. In my honest opinion, I believe that she thinks I will relapse, and thus her reasoning for maintenace..
But this is why I went in search of answers from various Dr's, and ended up in Schiff's office.
For me, Maintanece was not the answer, as on the meds, my ALT's where still elevated. So my liver was not getting a break so to speak. One of the Dr's I consulted with even suggested that the elevation in ALT's was the regeneration of the liver, and the destruction and dying off of prior scar tissue. That this was a newly thought theory going around the medical community at the time, and some what substantiated by the Fibroscan results towards the latter part of my tx.
Tx is such a "security" blanket for us, it is hard to throw in the towel. We may complain and whine the whole way through, but when it comes time to end it, it is HARD to let go. Sometimes you just have to roll and dice and play the odds.
Good luck with whatever you do, and keep checking that pulse!!! LOL
Just so I'm clear -- did your PA want you to stay on half doses of peg alone for a half year to a year -- or did he want you to stay on half doses of peg while continuing a full dose of riba?
Well, I did exactly as Schiff advised, and only went 48.. I did however throw in some Riba for and extra week or two post, as the Peg has a cummulative effect, and is still in the system following tx. But as far as Riba, I sort of followed a "pulsing" method. I know Califia also tinkered with this method.
I was 175lbs at the start of tx, and Rx'ed 1000mg of Riba. Was undetectable at week 12, and stayed the course of tx without ANY dose reductions or preemptive meds to counter effects. I was however becoming anemic towards the latter part of tx.
So like I said, I started at 1000mg a day. On weeks when I felt good, or "better", I would up the Riba to lets say 1200. If That took without a noticable change, I upped it to 1400mg. At 1400mg I noticed headaches, anxiety worsened, and I felt like ****...So I dropped back down to 1000mg. Once I felt a bit better again, I upped it back to 1400mg, and on somedays, 1600mg. Again, sort of "pulsing" with the increses.. There where a few days when I took as much as 1800mg, but for only a few days. I would then drop back to Rx'ed levels to stabilize.
I especially hit it hard toward the latter part of tx, as I figured I had already accomplished my 80%, and could risk the increses without the threat of being ordered off.
I wanted to go longer as you know, but followed the advise of Schiff. My PA wanted me to extend half dose for 6 months to a year post, following the guidlines of the HALT C studies.
What I was told abouit the Peg, especially Pegasys, is that it metabolizes slower. It has a half life so to speak, and a cummlative effect. Say you stop tx on Friday, well the following Friday, you will still have half that previous shot in your system. Then the following week, half that. Not sure if theory is correct or not, but that was my reasoning for continued Riba post my last shot.
Right now I'm 3 months post the stop of my tx, and I feel great. Body is still achey, more so than on tx, but my stamina and energy levels are up dramatically. I will get lab work done in the next week or so, and a PCR to see if I won this battle.
My 1 month labs revealed my ALT to be down to 21, which is a GREAT improvment, as my ALT's NEVER normalized during tx.
Good luck with whatever you do, and don't give that drgon ANY sympathy!! Kick him while he's down, then kick him again! Heck, kick him again, then drag him behind the car!!! LOL.
I was 175lbs at the start of tx, and Rx'ed 1000mg of Riba. Was undetectable at week 12, and stayed the course of tx without ANY dose reductions or preemptive meds to counter effects. I was however becoming anemic towards the latter part of tx.
So like I said, I started at 1000mg a day. On weeks when I felt good, or "better", I would up the Riba to lets say 1200. If That took without a noticable change, I upped it to 1400mg. At 1400mg I noticed headaches, anxiety worsened, and I felt like ****...So I dropped back down to 1000mg. Once I felt a bit better again, I upped it back to 1400mg, and on somedays, 1600mg. Again, sort of "pulsing" with the increses.. There where a few days when I took as much as 1800mg, but for only a few days. I would then drop back to Rx'ed levels to stabilize.
I especially hit it hard toward the latter part of tx, as I figured I had already accomplished my 80%, and could risk the increses without the threat of being ordered off.
I wanted to go longer as you know, but followed the advise of Schiff. My PA wanted me to extend half dose for 6 months to a year post, following the guidlines of the HALT C studies.
What I was told abouit the Peg, especially Pegasys, is that it metabolizes slower. It has a half life so to speak, and a cummlative effect. Say you stop tx on Friday, well the following Friday, you will still have half that previous shot in your system. Then the following week, half that. Not sure if theory is correct or not, but that was my reasoning for continued Riba post my last shot.
Right now I'm 3 months post the stop of my tx, and I feel great. Body is still achey, more so than on tx, but my stamina and energy levels are up dramatically. I will get lab work done in the next week or so, and a PCR to see if I won this battle.
My 1 month labs revealed my ALT to be down to 21, which is a GREAT improvment, as my ALT's NEVER normalized during tx.
Good luck with whatever you do, and don't give that drgon ANY sympathy!! Kick him while he's down, then kick him again! Heck, kick him again, then drag him behind the car!!! LOL.
Yeah, at the end, it's less a science than a gunfight in the dark, LOL.
I guess I've been doing some of what you call "pulsing" lately with the riba and 1600 does seem to make my pulse sick. LOL.
As you probably know I started with a very high dose (2000 mg/day) for the first week or so when I weighed 176 lbs. That was too much, too soon and I not only ended up in the ER but had to go off riba for five days. After that I stayed on 1200 mg/day for the next 30 weeks or so even though my weight was around 150 for most of the time. About six weeks ago I was feeling particularly bad and dropped to 1000mg/day. The reduced riba didn't seem to make any difference so I went back up to 1200. The past couple of weeks I've added an extra pill here and there but I started to feel the effects one day at 1600mg and decided to hold the course for now at 1200 probaby/maybe until at least week 48.
After that, one doctor suggested I go on declining maintenance doses of peg for another 12 weeks while staying on full riba. Haven't made this decision yet nor have I read any studies relevant and I'd like to know the theory behind this before I proceed. In Halt C, I imagine, they just ended with mainteance peg but no riba. And in your case -- you did the opposite -- no peg, just riba. What I'm actually toying with is an additional 12 weeks of mainteance levels of peg with a little extra riba. We'll see when the time comes. On one hand, I'm now enjoying feeling half-normal and therefore reluctant to screw things up. But on the other, I figure my job at this point is not to feel good but to kill the virus. I'm sure you know what I'm going through because gave a lot of thought to your end game as well.
-- Jim
I guess I've been doing some of what you call "pulsing" lately with the riba and 1600 does seem to make my pulse sick. LOL.
As you probably know I started with a very high dose (2000 mg/day) for the first week or so when I weighed 176 lbs. That was too much, too soon and I not only ended up in the ER but had to go off riba for five days. After that I stayed on 1200 mg/day for the next 30 weeks or so even though my weight was around 150 for most of the time. About six weeks ago I was feeling particularly bad and dropped to 1000mg/day. The reduced riba didn't seem to make any difference so I went back up to 1200. The past couple of weeks I've added an extra pill here and there but I started to feel the effects one day at 1600mg and decided to hold the course for now at 1200 probaby/maybe until at least week 48.
After that, one doctor suggested I go on declining maintenance doses of peg for another 12 weeks while staying on full riba. Haven't made this decision yet nor have I read any studies relevant and I'd like to know the theory behind this before I proceed. In Halt C, I imagine, they just ended with mainteance peg but no riba. And in your case -- you did the opposite -- no peg, just riba. What I'm actually toying with is an additional 12 weeks of mainteance levels of peg with a little extra riba. We'll see when the time comes. On one hand, I'm now enjoying feeling half-normal and therefore reluctant to screw things up. But on the other, I figure my job at this point is not to feel good but to kill the virus. I'm sure you know what I'm going through because gave a lot of thought to your end game as well.
-- Jim
this always gets me wondering if my riba dose should be higher?i weigh 210(hey i'm 6'3"!!) & my vl at trx inception was 9,000,000 (i know,i know) but well down from personal worst of 23,000,000.........i am currently chokin down 1200mg a day ,i did manage to talk my way around the 12 week vl test ,so should have some hard data about progress at 4 week ,tho i won't get this for a while longer.....Heck what's my question?? i will cross that bridge when i get to it!--if warranted i can up the riba well befor 12 wk test,right?...I am presently takin all that my docs ever allow,so i shall need to marshall lots of info&moxie--but then i can find plenty of willing coaches&cheerleaders (from whence comes the sports analogys??)ohh so then i switch to old english!!--it's been a rough couple of days at the homestead,kinda buried on the couch,feelin real BLAH:headaches,body aches,bloated,weak& go figure-depressed about everything!!! week 5 sucks!!--just got shipmnt of more drugs tonite,i have 7 weeks worth sitting here,initially satisfying(takin care o business..) but it also overwhelming all that chemical poison i gotta keep swallowing dutifully--Oh well,it's my job for now to Cure ..sorry for the ramble,thanks for insights&levity
I'd like to mention that as a boy, who contracted HCV at birth from my mother, the RISK is HIGH enough!!!!
I don't know if you missed my response in the other thread regarding increased riba near the end of treatment.
I remembered you said something a while back about extending your treatment a little beyond the 48-weeks with either more riba or peg. What exactly did you end up doing or did you just treat to 48 weeks with normal doses?
As I mentioned earlier, I'm thinking of added a little riba at the end and/or staging down the Peg from week 48 to 60 but haven't come to any decisions. As a matter of fact, I'm starting to feel yesterday's extra riba which leads me to believe that if I'm going to extend to 60 weeks on a lower peg dose, I may have to forgo the extra riba or vice versa.
-- Jim
I remembered you said something a while back about extending your treatment a little beyond the 48-weeks with either more riba or peg. What exactly did you end up doing or did you just treat to 48 weeks with normal doses?
As I mentioned earlier, I'm thinking of added a little riba at the end and/or staging down the Peg from week 48 to 60 but haven't come to any decisions. As a matter of fact, I'm starting to feel yesterday's extra riba which leads me to believe that if I'm going to extend to 60 weeks on a lower peg dose, I may have to forgo the extra riba or vice versa.
-- Jim
Amen I can see how you would totally be the one to understand THAT!
It's like a bad lotto - but you will beat this and be FINE.
It's like a bad lotto - but you will beat this and be FINE.
LMAO! I actually retyped my post, as that is originally how it sounded. But you wouldn't let me escape gracefully! LOL
Couldn't said prev: "Geez, yours was so much shorter......."
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That was you in the men's room the other day ?
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That was you in the men's room the other day ?
i've had hep-c for at least 20yrs and i have three girls; 18, 15, and 11. i've had them all tested and thank god they were all negative! that's pretty scary.
michelle
michelle
Geez, yours was so much shorter..........I think my link was longer than the story LOL
http://today.reuters.co.uk/news/newsArticle.aspx?type=healthNews&storyID=2005-12-15T202733Z_01_MUN573572_RTRIDST_0_HEALTH-HEALTH-HEPATITIS-MOTHERS-DC.XML&archived=False
Here's the link.
Here's the link.
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