Aa
Stevia/curcumin, INTERESTING
Herbal Product Stevioside Inhibits HCV Replication and Curcumin Suppresses Fibrogenic Cell Activity in Laboratory Studies
Last updated:26June2008
Intro
Stevioside
Curcumin
By Liz Highleyman hivandhepatitis.com
Intro
Given the suboptimal response rate and difficult side effects associated with standard interferon-based therapy for chronic hepatitis C virus (HCV) infection, many patients have used various alternative and complementary therapies, and researchers have assessed several such agents in laboratory and clinical studies.
At the Digestive Disease Week 2008 conference last month in San Diego, researchers reported on 2 plant-derived therapies that may have the potential to inhibit HCV and improve liver fibrosis.
Top
Stevioside
In the first study, Kazuhisa Yuasa and colleagues assessed the in vitro anti-HCV activity of stevioside, an agent derived from the leaves of the Stevia rebaudiana plant that is used as a natural non-caloric sweetener.
Stevioside has been reported to have anti-inflammatory and antioxidant properties, as well as an antiviral effect on rotavirus. According to background information provided the investigators, some chronic hepatitis C patients who regularly use stevioside have exhibited decreased HCV RNA or undetectable viral load in the absence of interferon-based therapy.
In the present study, the researchers evaluated the antiviral effect of stevioside on HCV replication using HCV replicon systems. They used ORN/C-5B/KE cells supporting genome-length HCV RNA encoding the luciferase reporter gene, and O cells replicating the genome-length HCV RNA in a real-time transcription polymerase chain reaction analysis.
Both cell systems were exposed to several concentrations of sterilized stevioside. The investigators assessed cytotoxicity, effect on signal transduction pathways, and anti-HCV activity (with and without interferon).
Results
• A diluted solution of stevioside demonstrated no cytotoxicites to either ORN/C-5B/KE cells or O cells.
• In both replicon systems, diluted stevioside suppressed HCV RNA in a dose-dependent manner.
• A 1000 times diluted stevioside solution inhibited HCV replication by about 30%.
• The same solution activated interferon-stimulated response element and 2-5A synthesizing enzyme gene promoter, but not the NF-kappa-?B gene promoter.
• Exposure to stevioside and interferon in combination produced an additive, but not a synergistic antiviral effect.
"We showed [the] anti-HCV effect of stevioside and the additive anti-HCV effect by combination of stevioside with interferon in vitro, and the activation of interferon signal was considered as one of the mechanism[s]," the investigators stated.
Thus, they concluded that, "stevioside is a possible antiviral agent for hepatitis C virus infection," and they plan to conduct a pilot study of the safety and efficacy of stevioside therapy for patients with chronic hepatitis C.
Top
Curcumin
Looking at another herbal therapy, Anping Chen and colleagues presented 3 laboratory studies assessing at the effect of curcumin on hepatic stellate cells.
Curcumin is the main component of the curry spice turmeric, derived from the Curcuma longa plant. Prior research indicates that it has antioxidant, anti-inflammatory, and anti-tumor properties. Hepatic stellate cells produce extracellular matrix proteins such as collagen that are responsible for liver fibrosis.
In the first study, the investigators found that curcumin promotes peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene expression and suppresses expression of the low-density lipoprotein (LDL) cholesterol receptor gene, which in turn lowers the level of intracellular cholesterol and thereby reduces the stimulatory effect of LDL on hepatic stellate cell activation.
In the second study, the researchers demonstrated that curcumin diminished the activating effect of oxidized LDL on stellate cells by suppressing LOX-1 gene expression, again via PPAR-gamma activation. Conversely, pre-treating the cells with a PPAR-gamma antagonist (PD68235) eliminated the inhibitory effect of curcumin.
Finally, the investigators showed that by increasing oxidative stress, insulin stimulates hepatic stellate cell proliferation and collagen production. But curcumin suppressed insulin-induced stellate cell activation by interrupting the insulin signaling pathway and reducing oxidative stress, via the same PPAR-gamma mechanism.
Hyperlipidemia (elevated blood lipid levels), obesity, and insulin resistance are features of the metabolic syndrome, which is associated with liver steatosis (accumulation of fat in hepatocytes). Steatosis is linked to fibrosis in individuals with non-alcoholic fatty liver disease, as well as those with chronic hepatitis C. Further, steatosis and insulin resistance are factors associated with poor response to interferon-based anti-HCV therapy.
The results of these laboratory studies suggest that curcumin or related agents that work by a similar mechanism might reduce fibrosis associated with hyperlipidemia or insulin resistance in individuals with or without hepatitis C.
6/10/08
References
K Yuasa, K Sato, A Naganuma, and others. Stevioside as a possible antiviral agent for hepatitis C virus infection. Digestive Disease Week (DDW) 2008. San Diego, CA. May 17-22, 2008. Abstract S1943.
Q Kang and A Chen. Curcumin suppresses LDL receptor gene expression, leading to the inhibition of cholesterol/LDL-induced hepatic stellate cell activation. Digestive Disease Week (DDW) 2008. San Diego, CA. May 17-22, 2008. Abstract S1584.
Last updated:26June2008
Intro
Stevioside
Curcumin
By Liz Highleyman hivandhepatitis.com
Intro
Given the suboptimal response rate and difficult side effects associated with standard interferon-based therapy for chronic hepatitis C virus (HCV) infection, many patients have used various alternative and complementary therapies, and researchers have assessed several such agents in laboratory and clinical studies.
At the Digestive Disease Week 2008 conference last month in San Diego, researchers reported on 2 plant-derived therapies that may have the potential to inhibit HCV and improve liver fibrosis.
Top
Stevioside
In the first study, Kazuhisa Yuasa and colleagues assessed the in vitro anti-HCV activity of stevioside, an agent derived from the leaves of the Stevia rebaudiana plant that is used as a natural non-caloric sweetener.
Stevioside has been reported to have anti-inflammatory and antioxidant properties, as well as an antiviral effect on rotavirus. According to background information provided the investigators, some chronic hepatitis C patients who regularly use stevioside have exhibited decreased HCV RNA or undetectable viral load in the absence of interferon-based therapy.
In the present study, the researchers evaluated the antiviral effect of stevioside on HCV replication using HCV replicon systems. They used ORN/C-5B/KE cells supporting genome-length HCV RNA encoding the luciferase reporter gene, and O cells replicating the genome-length HCV RNA in a real-time transcription polymerase chain reaction analysis.
Both cell systems were exposed to several concentrations of sterilized stevioside. The investigators assessed cytotoxicity, effect on signal transduction pathways, and anti-HCV activity (with and without interferon).
Results
• A diluted solution of stevioside demonstrated no cytotoxicites to either ORN/C-5B/KE cells or O cells.
• In both replicon systems, diluted stevioside suppressed HCV RNA in a dose-dependent manner.
• A 1000 times diluted stevioside solution inhibited HCV replication by about 30%.
• The same solution activated interferon-stimulated response element and 2-5A synthesizing enzyme gene promoter, but not the NF-kappa-?B gene promoter.
• Exposure to stevioside and interferon in combination produced an additive, but not a synergistic antiviral effect.
"We showed [the] anti-HCV effect of stevioside and the additive anti-HCV effect by combination of stevioside with interferon in vitro, and the activation of interferon signal was considered as one of the mechanism[s]," the investigators stated.
Thus, they concluded that, "stevioside is a possible antiviral agent for hepatitis C virus infection," and they plan to conduct a pilot study of the safety and efficacy of stevioside therapy for patients with chronic hepatitis C.
Top
Curcumin
Looking at another herbal therapy, Anping Chen and colleagues presented 3 laboratory studies assessing at the effect of curcumin on hepatic stellate cells.
Curcumin is the main component of the curry spice turmeric, derived from the Curcuma longa plant. Prior research indicates that it has antioxidant, anti-inflammatory, and anti-tumor properties. Hepatic stellate cells produce extracellular matrix proteins such as collagen that are responsible for liver fibrosis.
In the first study, the investigators found that curcumin promotes peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene expression and suppresses expression of the low-density lipoprotein (LDL) cholesterol receptor gene, which in turn lowers the level of intracellular cholesterol and thereby reduces the stimulatory effect of LDL on hepatic stellate cell activation.
In the second study, the researchers demonstrated that curcumin diminished the activating effect of oxidized LDL on stellate cells by suppressing LOX-1 gene expression, again via PPAR-gamma activation. Conversely, pre-treating the cells with a PPAR-gamma antagonist (PD68235) eliminated the inhibitory effect of curcumin.
Finally, the investigators showed that by increasing oxidative stress, insulin stimulates hepatic stellate cell proliferation and collagen production. But curcumin suppressed insulin-induced stellate cell activation by interrupting the insulin signaling pathway and reducing oxidative stress, via the same PPAR-gamma mechanism.
Hyperlipidemia (elevated blood lipid levels), obesity, and insulin resistance are features of the metabolic syndrome, which is associated with liver steatosis (accumulation of fat in hepatocytes). Steatosis is linked to fibrosis in individuals with non-alcoholic fatty liver disease, as well as those with chronic hepatitis C. Further, steatosis and insulin resistance are factors associated with poor response to interferon-based anti-HCV therapy.
The results of these laboratory studies suggest that curcumin or related agents that work by a similar mechanism might reduce fibrosis associated with hyperlipidemia or insulin resistance in individuals with or without hepatitis C.
6/10/08
References
K Yuasa, K Sato, A Naganuma, and others. Stevioside as a possible antiviral agent for hepatitis C virus infection. Digestive Disease Week (DDW) 2008. San Diego, CA. May 17-22, 2008. Abstract S1943.
Q Kang and A Chen. Curcumin suppresses LDL receptor gene expression, leading to the inhibition of cholesterol/LDL-induced hepatic stellate cell activation. Digestive Disease Week (DDW) 2008. San Diego, CA. May 17-22, 2008. Abstract S1584.
excellent info! I have great hope that these supplements when added to soc will greatly increase svr rates. Thank you for this.
Thinking that I have two bottles of liquid dark stevia sitting in my cupboard. I don't use it that often, because it is way too sweet. I prefer not to use a little agave nectar.
I did not know that it could be used for hep c. How should it be used and how much, that is the question now. Gauf??? I'm sure you will come with a strategy in no time... Please let us know what you find out.
To its other uses...
I've used it on infected wounds and it heals up an infection in no time. We had a musician friend come visit from Mali and he had hurt himself before coming and had this nasty infected sore on his heal and was limping. I put the Stevia on him and he almost killed me, it hurt so much. The next morning he was already better and actually asked for more. He walked normal after three days and the wound was totally healed up after 10 days.
Just thinking, maybe one could use it on mouth sores on tx. It stings like hell, but heals fast.
Marcia
I did not know that it could be used for hep c. How should it be used and how much, that is the question now. Gauf??? I'm sure you will come with a strategy in no time... Please let us know what you find out.
To its other uses...
I've used it on infected wounds and it heals up an infection in no time. We had a musician friend come visit from Mali and he had hurt himself before coming and had this nasty infected sore on his heal and was limping. I put the Stevia on him and he almost killed me, it hurt so much. The next morning he was already better and actually asked for more. He walked normal after three days and the wound was totally healed up after 10 days.
Just thinking, maybe one could use it on mouth sores on tx. It stings like hell, but heals fast.
Marcia
check this out--start Alinia predose 7/6 -starting today I'll start loading the grapefruit, 3-4 a day, sip GF juice all day, sweetened with a fair ammount of stevia! (not taking anything that GF would bother) Give the little devils a wake up call. A softening up if you will. I'l also switch my sweetener from agave to stevia thru out tx. Save the oxymatrine and lactoferren for the sub-UNDies. jerry
Look into what is rated to be the highest source of anti-oxidants of all, pomegranate juice. You must be sure it's pure. Lander's makes one available at Costco. I drink a small glass every day and the Gastro said he advises it. Careful not to drink too much, as some studies show excessive amounts may affect the kidneys. Just like anything else, do it in moderation. I also take a daily dose of 1000mg of Concentrated Extract Milk Thistle by Rexall, available at Wal-Mart. Sam-E proved not to really benefit the liver, so I stopped that after several years.
Magnum
Magnum
the conversation about stevia is very interesting to me as I have been seriously thinking about using it in my coffee instead of sugar, can't do the coffee with out the sweetner. I never knew it had antiviral properties let alone healing abilities. learn something new every day.
Denise
Denise
I'd exercise some caution here. For years stevia has been pushed by the medical quack community in an effort to disparage artificial sweeteners, which makes me rather suspicious of anybody who advocates its use. It is illegal in both the US and Europe to use stevia as a food additive, primarily because of its carcinogenic properties. If I were considering using it, I would do LOTS of research before putting it in my mouth.
I have been taking Stevia in my teas and its excellent as a mouth wash...i also been taking Turmeric morning and night.....added to a glass of orange juice and its amazily delcious.
I must terribly disagree with you. Stevia has nothing to do with quackery. I strongly believe that the reasons for Stevia not having been approved as a sweetener, is due to that the artificial sweetener industry is a huge profitable industry all over the world and it has been threatened by Stevia. Aspartame has been approved and has been proven to be potentially dangerous. So that speaks for itself.
In Japan Stevia is being used in many commercial foods instead of sugar. Japan has not involved themselves in this political game and has been researching it's safety long ago.
Here is some info on the political issue.
Marcia
Political controversy
The stevia plant may be grown legally in most countries, although some countries restrict or ban its use as a sweetener.
In 1991, at the request of an anonymous complaint, the United States Food and Drug Administration (FDA) labeled stevia as an "unsafe food additive" and restricted its import. The FDA's stated reason was "toxicological information on stevia is inadequate to demonstrate its safety."[36] This ruling was controversial, as stevia proponents pointed out that this designation violated the FDA's own guidelines under which any natural substance used prior to 1958 with no reported adverse effects should be generally recognized as safe (GRAS).
Stevia occurs naturally, requiring no patent to produce it. As a consequence, since the import ban in 1991, marketers and consumers of stevia have shared a belief that the FDA acted in response to industry pressure.[13] Arizona congressman Jon Kyl, for example, called the FDA action against stevia "a restraint of trade to benefit the artificial sweetener industry."[37] Citing privacy issues, the FDA has not revealed the source of the original complaint in its responses to requests filed under the Freedom of Information Act.[13]
The FDA requires proof of safety before recognizing a food additive as safe. A similar burden of proof is required for the FDA to ban a substance or label it unsafe. Nevertheless, stevia remained banned until after the 1994 Dietary Supplement Health and Education Act forced the FDA in 1995 to revise its stance to permit stevia to be used as a dietary supplement, although not as a food additive — a position that stevia proponents regard as contradictory because it simultaneously labels stevia as safe and unsafe, depending on how it is sold.[38]
Although unresolved questions remain concerning whether metabolic processes can produce a mutagen from stevia in animals, let alone in humans, the early studies nevertheless prompted the European Commission to ban stevia's use in food in the European Union pending further research.[14] Singapore and Hong Kong have banned it also.[15] However, more recent data compiled in the safety evaluation released by the World Health Organization in 2006[33] suggest that these policies may be obsolete.
In Japan Stevia is being used in many commercial foods instead of sugar. Japan has not involved themselves in this political game and has been researching it's safety long ago.
Here is some info on the political issue.
Marcia
Political controversy
The stevia plant may be grown legally in most countries, although some countries restrict or ban its use as a sweetener.
In 1991, at the request of an anonymous complaint, the United States Food and Drug Administration (FDA) labeled stevia as an "unsafe food additive" and restricted its import. The FDA's stated reason was "toxicological information on stevia is inadequate to demonstrate its safety."[36] This ruling was controversial, as stevia proponents pointed out that this designation violated the FDA's own guidelines under which any natural substance used prior to 1958 with no reported adverse effects should be generally recognized as safe (GRAS).
Stevia occurs naturally, requiring no patent to produce it. As a consequence, since the import ban in 1991, marketers and consumers of stevia have shared a belief that the FDA acted in response to industry pressure.[13] Arizona congressman Jon Kyl, for example, called the FDA action against stevia "a restraint of trade to benefit the artificial sweetener industry."[37] Citing privacy issues, the FDA has not revealed the source of the original complaint in its responses to requests filed under the Freedom of Information Act.[13]
The FDA requires proof of safety before recognizing a food additive as safe. A similar burden of proof is required for the FDA to ban a substance or label it unsafe. Nevertheless, stevia remained banned until after the 1994 Dietary Supplement Health and Education Act forced the FDA in 1995 to revise its stance to permit stevia to be used as a dietary supplement, although not as a food additive — a position that stevia proponents regard as contradictory because it simultaneously labels stevia as safe and unsafe, depending on how it is sold.[38]
Although unresolved questions remain concerning whether metabolic processes can produce a mutagen from stevia in animals, let alone in humans, the early studies nevertheless prompted the European Commission to ban stevia's use in food in the European Union pending further research.[14] Singapore and Hong Kong have banned it also.[15] However, more recent data compiled in the safety evaluation released by the World Health Organization in 2006[33] suggest that these policies may be obsolete.
I have gotten so used to drinking my herbal teas plain, that even a drop of Stevia tastes too sweet. My husband is a musician and singer and when he has been gigging days in a row, he uses the Stevia and it calms his throat.
It is actually really good for oral hygiene, as it inhibits the development of plaque and may actually help prevent cavities. This is backed by research.
Marcia
It is actually really good for oral hygiene, as it inhibits the development of plaque and may actually help prevent cavities. This is backed by research.
Marcia
I quite agree with the use of it...I've been using it for years because I'd developed insulin resistance and was headed down the path to becoming diabetic. I knew before most about aspartame breaking down into a formaldehyde-like compound (it breaks down at 98' F...Hmmmm Isn't our normal body temp 98.6 F?!?) the stevia is derived naturally from the "sweetleaf plant" (aka Stevia) and a tiny bit goes a long way...I get it in granular as well as liquid form, and have been able to incorporate it into my cooking...I'm happy to say, I'm no longer insulin resistant, and no signs of diabetes...
On a side note about quackery...When my daughter was born, we elected to hold off on immunizing her, as thimiserol (mercury)-free vaccines weren't available as yet. There was a strong link between SIDS,autism, and childhood vaccinations preserved with it. My husband and I were ridiculed and harassed for our stand...Now, 10 years later, the vaccination companies have finally admitted, there IS a link, and have removed this preservative from the injections...Once again, a huge money-maker, with a suppressed
and potentially damaging side effect that, until the distributor was pinned into a corner with 15(+) years of documentation, they kept pushing the "quackery" label on those that claimed their children had been harmed by their product....~Melinda
On a side note about quackery...When my daughter was born, we elected to hold off on immunizing her, as thimiserol (mercury)-free vaccines weren't available as yet. There was a strong link between SIDS,autism, and childhood vaccinations preserved with it. My husband and I were ridiculed and harassed for our stand...Now, 10 years later, the vaccination companies have finally admitted, there IS a link, and have removed this preservative from the injections...Once again, a huge money-maker, with a suppressed
and potentially damaging side effect that, until the distributor was pinned into a corner with 15(+) years of documentation, they kept pushing the "quackery" label on those that claimed their children had been harmed by their product....~Melinda
Those so called "Quackery Sites" are in cohots with big pharma ,they alays make out rages claims that herbs and spices will either kill you or make your prostate the size of a baseball...ignore them..and believe ,...those sites do exist...again...its all about money...greedy bastards.
I so agree with you. I have stayed away from aspartame forever, too. Whenever I look at something saying sugarfree, I get very alarmed. I'd rather have a little sugar in a good old fashioned chewing gum, than chewing aspartame. It's in everything ....
As you say, Stevia is also good for diabetics, in your case, it saved you from becoming.
As you say, Stevia is also good for diabetics, in your case, it saved you from becoming.
I will seriously experiment with this during tx, if not for the virus (or rather against it) for tooth hygiene and keeping the mouth from getting ulcers. Especially two drops at night after brushing my teeth, should do the trick.
Lets see what will happen..
Marcia
Lets see what will happen..
Marcia
Its strange how some people think just because a food can help you get well and they turn around and say its snake oil...how bout simple lemons...they are an excellent remedy for a lts of things...a great "liver food" too....come on people smarten up....this message should get some people responding....LOL
I think ANY THING that you INGEST
Will have some effect or not.
Whether it is natural or chemical or man-made.
I think that some things will have positive effects - some will have negative effects and others will still have both.
In this - the lesson merely lies with the individual - and how each individual reacts to medication, supplements, foods, environment, etc.
Each human being is different - with different DNA strands and molecules.
We are not a ONE SIZE fits all.
However, as a whole unit - we can be "common" - in that we commonly may be affected certain ways by specific items.
For example: A person who has ingested anti-venom for a snake --- may tolerate well a snake bite that is poisonous... Whereas - a person who has not taken the anti-venom will die a tragic death. OR --- someone who has a natural resistance may only get very ill.
The reason I note this so strongly --- that each person is affected differently --- is because of how I react to medicines compared to other individuals.
One of the MOST stand out points was made to me when I tried RITALIN.
(For those of you who don't know - I'm ADHD - always have been).
Ritalin, for most people reacts in their bodies like SPEED or Amphetamine. (why? Because that is exactly what it is... LOL!)
Anyhow - when "I" take ritalin... I get excessively Hungry and very sleepy.
Which goes 100% against the grain of "normal" society.
So - that tells me that I have interesting reactions to medications.
I have also noted that when I drink or eat anything that contains Nutrasweet for an extended period of time - I get very "ill-ish" feeling. And I can't seem to concentrate very well...
So this tells me something important.
What may be good for the goose... May not be good for the OTHER Goose... *grin*
I think when science determines that each person must be treated individually - and that different people have different reactions - we WILL lose this "SNAKE OIL" mentality.
Until then - each of us is shoved into a little box that says "one size fits all".
I hope that made sense.
I'm not much of a Stevia fan - it tastes funny to me. But if it could be put in a pill form - I could take it --- if my body determined that it worked.
Sweet - yeah --- but then I don't like Anise or Licorice either...
Still - hugs to y'all.
Meki
Will have some effect or not.
Whether it is natural or chemical or man-made.
I think that some things will have positive effects - some will have negative effects and others will still have both.
In this - the lesson merely lies with the individual - and how each individual reacts to medication, supplements, foods, environment, etc.
Each human being is different - with different DNA strands and molecules.
We are not a ONE SIZE fits all.
However, as a whole unit - we can be "common" - in that we commonly may be affected certain ways by specific items.
For example: A person who has ingested anti-venom for a snake --- may tolerate well a snake bite that is poisonous... Whereas - a person who has not taken the anti-venom will die a tragic death. OR --- someone who has a natural resistance may only get very ill.
The reason I note this so strongly --- that each person is affected differently --- is because of how I react to medicines compared to other individuals.
One of the MOST stand out points was made to me when I tried RITALIN.
(For those of you who don't know - I'm ADHD - always have been).
Ritalin, for most people reacts in their bodies like SPEED or Amphetamine. (why? Because that is exactly what it is... LOL!)
Anyhow - when "I" take ritalin... I get excessively Hungry and very sleepy.
Which goes 100% against the grain of "normal" society.
So - that tells me that I have interesting reactions to medications.
I have also noted that when I drink or eat anything that contains Nutrasweet for an extended period of time - I get very "ill-ish" feeling. And I can't seem to concentrate very well...
So this tells me something important.
What may be good for the goose... May not be good for the OTHER Goose... *grin*
I think when science determines that each person must be treated individually - and that different people have different reactions - we WILL lose this "SNAKE OIL" mentality.
Until then - each of us is shoved into a little box that says "one size fits all".
I hope that made sense.
I'm not much of a Stevia fan - it tastes funny to me. But if it could be put in a pill form - I could take it --- if my body determined that it worked.
Sweet - yeah --- but then I don't like Anise or Licorice either...
Still - hugs to y'all.
Meki
Well said....what works for some does not work for others....for example,when I smoke some "herb" it actually gets my mind in a creative mood and i have all kinds of energy,most people it makes them mellow and calm...for me ita a stimulant...same with blow...in my hey days that is....coca leaf make me relaxed....dont get paranoid ...as pertaining to health foods and supplements...same thing....the goose and gander rules apply in all things in life
There are many valid arguments for and against the use of "natural" substances as remedies. However, when I became diabetic I did tons of research on the aspartame issue and, based on journal articles by respected physicians and scientists, there is absolutely no proof of the dangers of aspartame - except to people with PKU and migraines. Period, end of story. The whole aspartame controversy was started by a spammer named Betty Martini, along with her doctor, H.J. Roberts, and the Mercola people and a few others. Don't believe them!! Millions of diabetics have used aspartame and other artificial sweeteners for decades with no ill effect.
My husband is a diabetic and we have attended classes with a registered dietitian who instructed how and what and when to eat. They encourage the use of artificial sweetners whether it be aspartame, splenda, sweet & low . We've used aspartame many years and it has not posed any problems so far. Studies show it also inhibits the growth of plaque and prevents tooth decay.
Trinity
Trinity
Anyone who recommends aspartame and says is good for you dont know what the hell is goin on?...plain and simple.
Well, maybe we should just stop drinking the city water and eating all processed food as well as fresh fruits and veggies that have been treated with pesticides and additives. Oh, and let's not forget the meats and fish as well!!
I dont eat processed food,i dont drink tap water,i dont eat fish and i hate dead cows....and i love organic fruits and veggies...im in love with organic whey powder and organic eggs....if it aint organic...i do not consume it into this body.
That works for you and don't have a problem with it. I haven't grown two heads yet so can't excited about the all natural thing. Raised 2 kids, both in excellent health. It's a matter of choice Rocker, doesn't mean you're going to live any longer or feel any better than those of us that choose the YUCKY stuff. I'm sure you understand where I'm coming from.
Trinity
Trinity
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