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NASH Liver Biopsy Results
Could you please explain what this liver biposy result means in plain language? Thanks.
The overall architecture is preserved. There is diffuse macro and microvesicular steatosis involving approximately 50% of the hepatocytes. The portal tracts appear unremarkable. There are focal lobular necroinflammatory changes and glucogenized nuclei. \Trichrome stain reveals sinusoidal and septal fibrosis mainly in the perivenular zone. Iron stain is negative for stainable iron. PAS stain with diastase digestion reveals adequate glycogen and no PAS positive intracytoplasmic globules.
The overall architecture is preserved. There is diffuse macro and microvesicular steatosis involving approximately 50% of the hepatocytes. The portal tracts appear unremarkable. There are focal lobular necroinflammatory changes and glucogenized nuclei. \Trichrome stain reveals sinusoidal and septal fibrosis mainly in the perivenular zone. Iron stain is negative for stainable iron. PAS stain with diastase digestion reveals adequate glycogen and no PAS positive intracytoplasmic globules.
Hi!
Have you seen your GI after this biopsy was done?
He is the most qualified person to explain the results, and it is his responsibility to make sure the patient is informed and clear about their condition.
We are mostly patients at this forum and not qualified to offer medical advice, only opinions and direction to other sites if needed.
good luck to you
Have you seen your GI after this biopsy was done?
He is the most qualified person to explain the results, and it is his responsibility to make sure the patient is informed and clear about their condition.
We are mostly patients at this forum and not qualified to offer medical advice, only opinions and direction to other sites if needed.
good luck to you
Zedarina, as already stated, we as fellow patients can't give you a true meaning of your biopsy...However there is a lot of information you can look at until your doc can explain these results....My favorite site is...janis7hepc.com........you can get a ton of "plain language" explanations at this website....good luck and God Bless
Chevy, you go girl!!!! What excellent news, I am soooo happy for you! The rest of this "bug juice" is going to take care of those blood varmits forever. What a GREAT DAY!
Pete
Pete
Philaguy; nice to "see" ya again. I recently got my peg package, after 30 shots or so, and was wondering about the blue thingy too, i figured it was for those puffy, dark circled eyes, but thats my guess, maybe we can call the assist line and ask them what all those compartments in the travel bag are for also...lol.
Even if you are not going to need the extra meds, it is good to know if s/he is willing to prescribe what you might need; procrit, neupogen, etc.
Most of these practices do not prescribe strong pain meds, so you might need your PCP for that, have your GI fax copies of ALL labwork to your primary, you will need him to assist when your GI won't.(FOR TMXJ also)These meds might be needed on the days every thing aches like a bad case of the Breakbone fever.
I was able to manage w/o ads so far,#43 tonite, the moods have passed every time. Have someone keep an eye on your behaviour, in case you don't notice the changes. My practice does the Beck electronic assessment at every visit for mental health changes. It does not seem everyone here gets this.
I told my immediate supervisor only and personnel does not know. I figure if it becomes unmanageable at least one person has known all along and can attest to my situation.
You will probably do ok, like most of us, with manageable sx.
Keep us posted.
ALL
I really hate this thing with only 20 comments per thread, I guess they want to control our chit chatting and/or bickering.
So, for those who haven't posted in a while and have not noticed this change, try to post all you can in ONE comment, please.
Now we are really limited. I am trying hard to only post once per thread to give all a chance.
be well
Even if you are not going to need the extra meds, it is good to know if s/he is willing to prescribe what you might need; procrit, neupogen, etc.
Most of these practices do not prescribe strong pain meds, so you might need your PCP for that, have your GI fax copies of ALL labwork to your primary, you will need him to assist when your GI won't.(FOR TMXJ also)These meds might be needed on the days every thing aches like a bad case of the Breakbone fever.
I was able to manage w/o ads so far,#43 tonite, the moods have passed every time. Have someone keep an eye on your behaviour, in case you don't notice the changes. My practice does the Beck electronic assessment at every visit for mental health changes. It does not seem everyone here gets this.
I told my immediate supervisor only and personnel does not know. I figure if it becomes unmanageable at least one person has known all along and can attest to my situation.
You will probably do ok, like most of us, with manageable sx.
Keep us posted.
ALL
I really hate this thing with only 20 comments per thread, I guess they want to control our chit chatting and/or bickering.
So, for those who haven't posted in a while and have not noticed this change, try to post all you can in ONE comment, please.
Now we are really limited. I am trying hard to only post once per thread to give all a chance.
be well
I am having my 3rd biopsy on Mon. the 26th. I've asked them to stage and grade it this time as the other two I've had were never staged/graded. I'll let you all know what I find out and how I do w/the bio. Susan400
Chevy; Exactly what I expected to hear, I couldn't be happier for you:)
Susan: Good luck!
Scott: Keep posting, please. As for the flames, we have fire extinguishers:)
Susan: Good luck!
Scott: Keep posting, please. As for the flames, we have fire extinguishers:)
Chevy, Chevy, Chevy! I am so happy for you. I knew with all your good vibes that there was only good news on the horizon for you. I'm so happy for you! Hang in there for the rest of the ride and get rid of this bugger for good!
I didn't get any numbers, but was only told that my 12 week was NEGATIVE for Hep C. Do your numbers mean that you are negative?
I hope so............I really enjoy your posts.
I hope so............I really enjoy your posts.
The West Coast of Canada is celebrating your great news with all the excitement of a 10 piece band. I salute you my celery stick and I toast you with my big tall glass of water!!! Congratulations Chevy, you deserve to be very happy.
Scott....Thanks for the article, really appreciate the ones that the layperson can decipher. You're great at searching them out.
Scott....Thanks for the article, really appreciate the ones that the layperson can decipher. You're great at searching them out.
I was never given a stage or grade either. Although your doctor would be the best person to explain your results to you, the important thing is that you have fibrosis, scarring, but not cirrhosis. As far as I understand, "septal" is a moderately bad stage (it's what I had) and you may well want to treat your Hep C at this point. Fibrosis can be reversed if you treat the hepatitis successfully.
Happy for everyone and think about you all even though I haven't posted in a while. Lately, when hit post comment or post question, the threads are closed to any new posts.
My 12 week results were not what I expected and left me feeling discouraged. Even though I had a significant drop in viral load, I felt disappointed that I wasn't undetectable. The week before treatment I had a viral load of 738,000. At 12 weeks, it was 290.
I'm now at week #18. I'm trying not to be discouraged, but I was told by a health care provider that I trusted that if I wasn't undetectable at 12 weeks, I probably wouldn't ever clear. Others have said that's not true, and that my drop was significant and that I'm probably clear by now.
I don't know how I'm supposed to feel. I want to be optimistic for the 24 week test, but I'm just scared and unbelievably tired and irritable.
Physically, I'm a mess...terrible itching ALL THE TIME. Has anyone else had the itchies? There's no rash or hives, my skin is perfectly smooth to the touch,,,the itch is coming from the inside of my body. The impulse to scratch is uncontrollable and it doesn't help...it just makes it feel like my skin is on fire.
That's all the whining I'll do for now. I'm not accustomed to feeling so negatively about everything, and I don't know how to handle it. I am on ad's, and they do seem to help somewhat . Any words of encouragement welcome. I want to feel as hopeful as the rest of you and I just can't seem to do that anymore (ever since the 12 week results).
Best to all,
Judi
My 12 week results were not what I expected and left me feeling discouraged. Even though I had a significant drop in viral load, I felt disappointed that I wasn't undetectable. The week before treatment I had a viral load of 738,000. At 12 weeks, it was 290.
I'm now at week #18. I'm trying not to be discouraged, but I was told by a health care provider that I trusted that if I wasn't undetectable at 12 weeks, I probably wouldn't ever clear. Others have said that's not true, and that my drop was significant and that I'm probably clear by now.
I don't know how I'm supposed to feel. I want to be optimistic for the 24 week test, but I'm just scared and unbelievably tired and irritable.
Physically, I'm a mess...terrible itching ALL THE TIME. Has anyone else had the itchies? There's no rash or hives, my skin is perfectly smooth to the touch,,,the itch is coming from the inside of my body. The impulse to scratch is uncontrollable and it doesn't help...it just makes it feel like my skin is on fire.
That's all the whining I'll do for now. I'm not accustomed to feeling so negatively about everything, and I don't know how to handle it. I am on ad's, and they do seem to help somewhat . Any words of encouragement welcome. I want to feel as hopeful as the rest of you and I just can't seem to do that anymore (ever since the 12 week results).
Best to all,
Judi
Wow...we sure are getting some great news around here.....I hope I remember everyone....trying to keep the brain fog in check....***HAPPY BIRTHDAY TO dh Bill***.....and what a great birthday present to be able to do the ole 10, 9, 8...etc countdown.***CHEV,FURBURCAT,DEBBIDO**: Congrats on your results (I am "thinking" CARTWHEELS) yahooooo.....
**eyehavegr8life**: glad you are done with your bx...and am sending prayers to you.
**Susan400**: will be thinking of you on Monday....(remind me again so that I can send up some prayers for you again)
**Oldhippiechick67** so sorry to hear that you are having a bad time...I am sending love and prayers to you.
**Cuteus** I will be thinking of you tonight when you do #43...I will be doing #46 tonight.....(Berlynn: how did #46 go for you last night.....I hope you saw my post a few days ago, I got my days mixed up...but I was thinking about you last night...you go, girl....I hope you are feeling better...I think I am) **Cuteus**....oh, yes...I am with you about the limited comments on this forum now. I wonder what happened? Has anyone found out the scoop, and is this only temporary?
***raheem, Harley Dude**: way to go.....after tonight's shot, I only have 2 more to go......
If I forgot someone....you are still in my heart....I am trying to do all of this on one post.
**********************I had my Dr appt today, and everything looks GREAT....my liver enzymes were up last appt, (doc said probably from the meds...nothing to worry about)..and TODAY..my counts were 45/52...down from 80's last time....yahoo.........
**eyehavegr8life**: glad you are done with your bx...and am sending prayers to you.
**Susan400**: will be thinking of you on Monday....(remind me again so that I can send up some prayers for you again)
**Oldhippiechick67** so sorry to hear that you are having a bad time...I am sending love and prayers to you.
**Cuteus** I will be thinking of you tonight when you do #43...I will be doing #46 tonight.....(Berlynn: how did #46 go for you last night.....I hope you saw my post a few days ago, I got my days mixed up...but I was thinking about you last night...you go, girl....I hope you are feeling better...I think I am) **Cuteus**....oh, yes...I am with you about the limited comments on this forum now. I wonder what happened? Has anyone found out the scoop, and is this only temporary?
***raheem, Harley Dude**: way to go.....after tonight's shot, I only have 2 more to go......
If I forgot someone....you are still in my heart....I am trying to do all of this on one post.
**********************I had my Dr appt today, and everything looks GREAT....my liver enzymes were up last appt, (doc said probably from the meds...nothing to worry about)..and TODAY..my counts were 45/52...down from 80's last time....yahoo.........
You go! This is such great news for someone who has tirelessly cheered on the rest of us. I am so happy for you. Celebrate with an extra glass of grape juice or another gallon of water!!!
well, my friend if you were given the test i had, that only tested to 615 you would have been said to be clear...like i was said to be...think about it...
none of us really think were "completely clear" at the 12 week stage...(READ NOTE ABOVE FROM SCOTT),it's just that we find out we are responding...FRIEND YOU ARE RESPONDING... THAT'S REASON FOR JOY AND PRAISE...SO RAISE YOUR IMMUNE SYSTEM A BIT BY PRAISING GOD AND REJOICING THAT YOU ARE A RESPONDER!!!!!!!!!!!!!!!!
none of us really think were "completely clear" at the 12 week stage...(READ NOTE ABOVE FROM SCOTT),it's just that we find out we are responding...FRIEND YOU ARE RESPONDING... THAT'S REASON FOR JOY AND PRAISE...SO RAISE YOUR IMMUNE SYSTEM A BIT BY PRAISING GOD AND REJOICING THAT YOU ARE A RESPONDER!!!!!!!!!!!!!!!!
well, my friend if you were given the test i had, that only tested to 615 you would have been said to be clear...like i was said to be...think about it...
none of us really think were "completely clear" at the 12 week stage...(READ NOTE ABOVE FROM SCOTT),it's just that we find out we are responding...FRIEND YOU ARE RESPONDING... THAT'S REASON FOR JOY AND PRAISE...SO RAISE YOUR IMMUNE SYSTEM A BIT BY PRAISING GOD AND REJOICING THAT YOU ARE A RESPONDER!!!!!!!!!!!!!!!!
none of us really think were "completely clear" at the 12 week stage...(READ NOTE ABOVE FROM SCOTT),it's just that we find out we are responding...FRIEND YOU ARE RESPONDING... THAT'S REASON FOR JOY AND PRAISE...SO RAISE YOUR IMMUNE SYSTEM A BIT BY PRAISING GOD AND REJOICING THAT YOU ARE A RESPONDER!!!!!!!!!!!!!!!!
well, my friend if you were given the test i had, that only tested to 615 you would have been said to be clear...like i was said to be...think about it...
none of us really think were "completely clear" at the 12 week stage...(READ NOTE ABOVE FROM SCOTT),it's just that we find out we are responding...FRIEND YOU ARE RESPONDING... THAT'S REASON FOR JOY AND PRAISE...SO RAISE YOUR IMMUNE SYSTEM A BIT BY PRAISING GOD AND REJOICING THAT YOU ARE A RESPONDER!!!!!!!!!!!!!!!!
none of us really think were "completely clear" at the 12 week stage...(READ NOTE ABOVE FROM SCOTT),it's just that we find out we are responding...FRIEND YOU ARE RESPONDING... THAT'S REASON FOR JOY AND PRAISE...SO RAISE YOUR IMMUNE SYSTEM A BIT BY PRAISING GOD AND REJOICING THAT YOU ARE A RESPONDER!!!!!!!!!!!!!!!!
well, my friend if you were given the test i had, that only tested to 615 you would have been said to be clear...like i was said to be...think about it...
none of us really think were "completely clear" at the 12 week stage...(READ NOTE ABOVE FROM SCOTT),it's just that we find out we are responding...FRIEND YOU ARE RESPONDING... THAT'S REASON FOR JOY AND PRAISE...SO RAISE YOUR IMMUNE SYSTEM A BIT BY PRAISING GOD AND REJOICING THAT YOU ARE A RESPONDER!!!!!!!!!!!!!!!!
none of us really think were "completely clear" at the 12 week stage...(READ NOTE ABOVE FROM SCOTT),it's just that we find out we are responding...FRIEND YOU ARE RESPONDING... THAT'S REASON FOR JOY AND PRAISE...SO RAISE YOUR IMMUNE SYSTEM A BIT BY PRAISING GOD AND REJOICING THAT YOU ARE A RESPONDER!!!!!!!!!!!!!!!!
Judi ~ You really have to forget what that person told you about probably never clearing if you weren't clear at 12 wks. It's just not true. I had someone at the doctor's office convey the same "doom" to me when I was not clear at 12 wks. I was undetectable at 24 weeks. If I could go back and do it again, though, I would have asked for PCRs more often so I had a closer idea of what week I cleared. We have now decided to extend my tx to 56 wks. Don't let anyone knock the fight out of you ~ your Vl was so low, that the day before or the day after, you may have been undetectable just with the fluctuations of testing. Keep your chin up. I hope the sx ease up for you soon.
ambush :)
ambush :)
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