Stopping at week 36

[Tekelcat]

Hi, I can't do it any more. 24 weeks of Pegasys and Ribavirin and Gilead GS5885 and Gilead 9451. Didn't UND until week 6 which according to the trial protocols means I must continue Pegasys and Ribavirin for another 24 weeks. Now at Week 36. Still UND, but have spent the last two weeks vomiting and nauseous all the time. I can't go to work, can't do my research and write my book and the sx have been getting worse. Tried Maxolon and Zofran. No effect and just made me really sleepy or gave me blinding headaches. last night at 2 am I retching blood into the toilet and at that point I decided, enough. No more. I'm out. maybe with UND since W6, the TT allele, and the Gilead drugs, I'll stay UND, but if not, that's. Just the way life goes. I don't have serious fibrosis and I need now to get healthy again, get back to my career. thoughts?

[2mlbb]

So happy that you are finding some solutions to stay on course with your treatment. I had some severe nausea issues a few times but found my way with the support of this team. I really am rooting for you that all will work out on your hard fought journey to freedom. The very best wishes :)

[Dawn703]

Try eating applesauce with your riba if you can't manage anything else, I got anorexia so bad during the incivek part that it was all I could get down with the riba, the 20 grams of fat with the incivek would put me over the edge as far as food went. The applesauce was light and kept me from getting sick from the riba. Good luck and so glad you're feeling better.

[Ironpony]

this makes me smile. So glad you are feeling better too.

best wishes
Laura

[willbb]

Good luck going forward...

Will

[Tekelcat]

Update: missed 3 doses of Ribavirin with hepa's approval. Nausea and vomiting eased almost immediately but not entirely gone.

FYI: Hepa seems to think that we can get caught in a loop with the Riba and nausea. He tells me that if we forget to take it with food more than a couple of times in a row, the nausea and vomiting can start and this begins a loop: nausea and vomiting stop us from eating so the Riba is even more damaging, so we eat even less, Riba gets even harsher, more vomit less eating, more Riba issues. This could be what happened to me as I was out of town for a long weekend 2 weeks ago and it was hard to time the Riba with proper food.

So missing three doses yesterday and early today seems to have broken the loop. I'm now back on a reduced Riba dose.  Still nausea but manageable and no vomiting. Decent food stays down!!!! Yay! Had my 37th Pegasys injection today too, took reduced Riba, ate a decent meal and feel, well, not okay, but kinda like I felt before the nausea started.

I am so very grateful to you all for your good advice, your kindness and patience during a very scary time for me.

[orphanedhawk]

I can't help but wonder if you are actually allergic to the meds.
If you have little to no fibrosis, stop !
The only reason I would do tx is to keep my liver healthy.