To many geno 2 and 3 relapsing... and not enough studies done.. all 2

[Mister beagle bailey]

I have found no real studies done on geno 2 and 3 and after seeing all the forum members post yesterday that they relapsed.  I thought it would be a good idea to group us together to see just how many of us there are.  This may help us see clearer what the next step should be.

Please sign in and give your stats:

Geno 2B
VL before tx: 318,000   relaped VL:  4 million
Did peg-intron 120  Riba 800  Did not lower dose durning treatment
Procrit since week 2  Did tx 24 weeks was UND still at shot 23
4 weeks post tx: ALT 13  AST 24

Thanks

Beagle

[hippygem]

Forgot to mention that I was also taking Losec, which is an antacid, before during and after tx.  I later read in this forum that antacids actually can have an affect on tx.
If someone has more information on this could they please supply a link.

thanks

linda

Revenire, welcome to the ozzy forum, nice to see you there.

[desrt]

in re: geno 3 falls between 1 and 2

Latest study I read on 12 week treatment shows type 2 maintaining 80% SVR while geno 3 falls to about 67%

[desrt]

genotype: 3e
baseline vl 625,000
probable date of infection: 1973 (based on being my third bout of acute hep - doc unable to explain since I already had A&B antibodies)
treated 24 weeks: 2002-2003  46-47 y.o.
1200 mg riba/don't remember IFN dose, but was weight based Peg-Intron for 220# and do remember that I was underdosed for first three weeks due to nurse's mistake
gastro was treating all genotypes 48 weeks with as much IFN and riba as you could stand (y'all would love this guy). at week 19 I read 2002 NIH consensus report stating non-geno 1 could treat 24 wks w/800 mg riba - lowered my dose to 800 mg and discontinued at 24 weeks against doc's advice and was still undetected 2 yrs post-tx (not saying I'm smarter than my doc - I took a chance and got lucky)
I'm not against high dosing, but I think people should be aware that even normal dosing can result in thyroid damage and auto-immune problems - at least that's what the people that make the stuff say on the package insert.

[Pdilly]

Geno 2 a and 2c   VL 308,000   Stage 2-3  Grade 2-3  due to start tx Sept 29.

[hippygem]

Geno 3
Fibrosis stage 2 (was 3 before tx)
Relapser
24 wks tx
tx in 2004

Was Undetectable during tx but after 6 month blood tests the virus had returned.

Here in Australia they are now suggesting that genotype 2 & 3 that have any stage of fibrosis/cirrhosis should now be on the tx for 48 weeks.

[Pauly Boy]

As this past weeks events have unfolded and we've become aware of our friends unfortunate relapses, I considered the possiblities that the info regarding the " cure" rates from HCV that I'd heard about, might need to be reevaluated. It seems that this is no different than anything else in our HCV world. We learn as we go along, everything we think we know about HCV leads us to a new discovery and just how much more we need to re-discover. It's no different than life.......... on Mars!!!
                           Keep killin' those critters
genotype----- 2b                     Pauly
VL at start-- 1.7MM
ALT---------- 52
AST---------- 39
HGB at start- 14.8
HGB in 3 weeks 9.8
Pegasys 180mcg
Riba---- 1200 daily/ at week 5- 1000
procrit since week 4- 1ML a week
UND at week 4 and week 12