Aa
To many geno 2 and 3 relapsing... and not enough studies done.. all 2
I have found no real studies done on geno 2 and 3 and after seeing all the forum members post yesterday that they relapsed. I thought it would be a good idea to group us together to see just how many of us there are. This may help us see clearer what the next step should be.
Please sign in and give your stats:
Geno 2B
VL before tx: 318,000 relaped VL: 4 million
Did peg-intron 120 Riba 800 Did not lower dose durning treatment
Procrit since week 2 Did tx 24 weeks was UND still at shot 23
4 weeks post tx: ALT 13 AST 24
Thanks
Beagle
Please sign in and give your stats:
Geno 2B
VL before tx: 318,000 relaped VL: 4 million
Did peg-intron 120 Riba 800 Did not lower dose durning treatment
Procrit since week 2 Did tx 24 weeks was UND still at shot 23
4 weeks post tx: ALT 13 AST 24
Thanks
Beagle
Goofy posted earlier on some recent studies for geno 2's and 3's, so I thought I'd recopy his post here. If he sees this he might post the link in a more elegant way but for now here it is to copy and paste in your browser window: http://tinyurl.com/juna9
Free registration required but well worth it.
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From the paper:
Taken together, these 4 studies indicate that shorter duration of therapy may be effective for patients with genotype 2 or 3 and RVR. However, in applying these findings to the clinical setting, physicians should take into account that patients in these protocols were treated with weight-based ribavirin (800-1400 mg/day or 1000-1200 mg/day) rather than the standard fixed-dose ribavirin (800 mg/day) approved by the US Food and Drug Administration (FDA) for the treatment of patients with HCV genotypes 2 or 3.
Personally, I like the idea of starting with higher riba knowing you can always cut back if it's not tollerated. If you maintain the high riba, you might consider the 16 week stopping point if you're having a difficult treatment or just plain want to. It's a reasonable course to take.
Good luck!
Free registration required but well worth it.
------------------------------------------
From the paper:
Taken together, these 4 studies indicate that shorter duration of therapy may be effective for patients with genotype 2 or 3 and RVR. However, in applying these findings to the clinical setting, physicians should take into account that patients in these protocols were treated with weight-based ribavirin (800-1400 mg/day or 1000-1200 mg/day) rather than the standard fixed-dose ribavirin (800 mg/day) approved by the US Food and Drug Administration (FDA) for the treatment of patients with HCV genotypes 2 or 3.
Personally, I like the idea of starting with higher riba knowing you can always cut back if it's not tollerated. If you maintain the high riba, you might consider the 16 week stopping point if you're having a difficult treatment or just plain want to. It's a reasonable course to take.
Good luck!
I'm in the kennel with you.
Geno3a
tx'd 24 weeks peg-intron and 800 riba
early cirrhosis
und at 12 and 24, relapsed at 5 month (1st post tx pcr)
required neup, ambien, not procrit
platelets averaged in the 60's
Next time (advised by a liverhead)
1200 riba (weigh-based for 180 lbs) probably pre-dose a week
48 weeks
not sure which peg yet
neup at 500, procrit at 11, platelets can go to 30
Geno3a
tx'd 24 weeks peg-intron and 800 riba
early cirrhosis
und at 12 and 24, relapsed at 5 month (1st post tx pcr)
required neup, ambien, not procrit
platelets averaged in the 60's
Next time (advised by a liverhead)
1200 riba (weigh-based for 180 lbs) probably pre-dose a week
48 weeks
not sure which peg yet
neup at 500, procrit at 11, platelets can go to 30
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