Calling all relapsers!!!!!!!!!

[HCA]

I would like ,just for curiousity to take a snapshot poll among relapsers.Must have completed treatment.
1) What genotype ?
2) Length of treatment?
3) Starting viral load?
4) Viral load/reduction as  tested each time during treatment,particularly interested in when first showed undetectible.
Obviously this is just general interest and in no way scientific,but fascinated to see how strong correlation between rapidity of response and sustainibility of viral respoonse among people in this forum.
Relapsere only please!

[Cory255]

Genotype 1a
44 wks tx
Starting viral load 5.5 million
Cleared the virus week 12
5 wks after tx viral load 1.5 million

[MissMiss]

I am interested in hearing if you had any inkling that it was back and what made you think so.  Any comments in this regard would be helpful.

miss

[downsolong]

) What genotype ?
2) Length of treatment?
3) Starting viral load?
4) Viral load/reduction as tested each time during treatment,particularly interested in when first showed undetectible.

59 years old, cirrhosis
geno 1a
treated twice, 2001 for 60 weeks, 2005 for 48 weeks.
beginning VL 900k and 2 million, respectively
Round one, used all rescue drugs and did not clear.  24 week PCR ~8,000.  48 week PCR 24,000.  Extended to 60 weeks and VL spiked to >300,000.

Round 2, cleared between week 4 and week 8, stayed clear till one month post tx.  Six month post tx PCR was >5 million.

[nygirl7]

Our good friends stats must be represented.

He was a geno2 and fought harder than just about anybody ever did that I've ever heard of.

Sorry I don't know more info.

Also my great friend Kalio who was a geno 3.

[marchingon]

1. Geno 2b
2. Round One 6 months 2004
   Round Two 12 months 2005/2006
3. Round One beginning Viral Load 1.8 mill
   Round Two beginning Viral Load 175K
4. Round One-UND throughout treatment 12 weeks thru 3 mos
   post treatment. Virus back by 6 mos lab.
   Round Two-UND throughout treatment 12 weeks thru 3
   mos lab. Virus back at 475K Dec 8th, and at 1.4
   ml on Dec. 28th.
   Dr. B.C. says wait now until VX-950 release. Hate to wait, but that's all we can do. I also hate to post this info because I don't want others currently on treatment or contemplating it to be discouraged. I would do battle again tomorrow if I thought my body could handle it or that it would do any good.
  

[donAlfonso]

male 57 yrs. infected 1970
Type 1a by doc report, 1b by transplant team test. who cares, 1 is 1
VL 2.5 million
cirrhosis
1st 2 weeks tx 1/2 dose due to dr concerns about my anemia
Start date 1/2/04
2/23/04  71,900
3/25     38,300
4/29     2,190
6/1      758
7/15     144
8/12     <5
decided to go 1 year beyond clearance date, undetectable til
6/23/05     12
repeated after 2 weeks and 4 weeks <5
stopped tx approx 8/7/05
9/7/05   97,600


Long, slow recovery from tx.  Now that I'm feeling better, I'm gearing up for another attempt.  New (big name)hepatologist agrees that induction tx w/Peg is best bet.  If not clear in first 12 weeks (the double dose period)I plan to stop.  

Hi Mike and Beans, good to see you.  My best to all.

dA

[Tater-ToT]

This is from memory as I do not have any of my official paperwork with me!

Combo 1a/1b...
aquired early 80's.. diagnosed 2003
Starting VL approx 5 mill little to no significant liver damage!

Total Time On Tx 110 weeks(split)

Round One (48 weeks)
was NOT clear by 12 week mile marker, but had 4&1/2 log drop. Undetectable by next PCR done @ 24 weeks!
Still Undetectable two weeks post TX
12 week post TX PCR =RELAPSE.. VL 6,000/Alts & Asts almost quadrupled
14 week post TX PCR(to begin new tx) .. VL dropped to 1000 on it's own / Alts & Ast back to high end of normal ranges!

Round 2 completed 62 weeks out of 72 ordered (insurance snafoo's)
UNDETECTABLE this time By initial 12 week PCR
4 month post TX PCR =Still UNDETECTABLE
Will be doing 1 year post TX pcr in April

All PCR's done using Heptamax <5
:)

[Better-Angels]

My Husband - Greg

Genotype - 1B
Starting VL - 9.23 Million
Started Tx June 03 - 48 Weeks Pegasys
Undetectible @ 18 days (less than 10)
Remained Undetectible throughtout Tx
Perfect Compliance
Remained Undetectible until 12 'months' post Tx.

Started second course of Tx in June 05. Daily Infergen (15 MCG's) for 6 months, then every other day for the remainder.
Starting VL - somewhere around 108,000
Undetectible @ 10 days
Remained the same throughtout Tx.
Perfect Compliance
So far Undetectible on his 6 month post Tx PCR (less than 5). Takes his 1 year PCR in May. Fingers Crossed!

[Bill1954]

1) Genotype 1a

2) 56 weeks, beginning 2/18/05 and ending 3/17/06

3) Baseline VL: 75,600 IU/mL

4a) 5/13/05 (12 week) bDNA quant. assay (615 IU/mL) indicated VL of 1460 IU/mL.
4b) 6/24/05 (20 week) bDNA quant. assay (615 IU/mL) indicated undetectable to limit of detection.
4c) 7/7/05   (~22 week) PCR quant. assay 50 IU/mL) indicated undetectable to limit of detection.

4/17/06 30 day PCR assay results indicate VL 112,000 IU/mL (relapse).

Currently re-treating with Peg-Interferon ~200 mcg/week, ribavirin 2000 mg/day for 72 weeks.

[jmjm530]

2Irish: Told by study doctor that i "WAS CURED!"
-----------------------------------------------
I hope this isn't the same wacko doc who you're now seeing. As a 1/2 hate to see you doubling up on the peg and extending these toxic drugs when some newer and shorter treatments hopefully will be available very soon. Vertex preliminary (4week post treatment, 24 week arm) data should be available within days or weeks. Good to see you droping by and wonderful to hear you're feeling great.

-- Jim

[Forseegood]

sorry for putting this here, but I don't think 2Irish goes to the other board, hey YOU, call me!:))

[SnoWav]

1A
48 weeks
1.5 mil
VL test at 12 weeks was wrong test ,tested again at 14 weeks clear to <10
That was the only test until 2 weeks post TX and clear.My doc,s wife I found out had terminal cancer so his mind was somewhere else during my TX. I had lots of pain and numbness in my arm and leg pain before TX that went away a few weeks after starting tx.One year later it is only slightly returned.  My BX was first graded at 1-2 then my new doc at teaching hospital graded same BX at 2-3. Had 2nd BX (it had been 5 yrs) and also after TX 0 1-1-2  looked much better alright some good news. Also VL 3 months after TX was 1/2 a mil. have had the bug for 35 yrs now going to wait out a better chance of clearing unless I get all my old pain back.later

[friole]

I am in shock.  This is the first I have read that you relapsed.  Dam this insidious disease!  I haven't consulted yet.  I don't know if they will suggest another biopsy.  Personally, I think it is a good idea. I would consider double dosing. What were your liver enzymes before during and after tx?  You can get ahold of me at my screenname ataoldotcom.

[2irish]

1a
48wks
starting VL 9 mill something
4wks about 1100
12 wks UND
24, 36, 48 UND
Told by study doctor that i "WAS CURED!"
3mos VL 1 million something
Biopsy Feb 15th
They are talking about double dosing & extending...not sure I'm jumping back in...feel great!
last biospsy1-2.

[friole]

Good idea -- I try to save all the relapse threads


Geno 1a
Pretreatment VL 1,520,000 IU/mL
12 week VL     40  IU/mL
20 week VL     UND by LabCrop QuantaSure to 2 IU/mL
Treated 56 weeks (ended 08/11/06).

Currently on hold. Have an appointment with a Hepatologist in April and we will see what is recommended.

frijole

[mikesimon]

Transplant recipient
Treated with 800 mg riba daily(too low) and Peg-Intron SOC  
Cleared late (week 40 something)
Type 1b
53 weeks
Relapsed within 3 weeks

Mike

[HCA]

Forgot to put my owm!
Geno 1a/1b
1 million
48 weeks
550 at 12 weeks
UND at 24,36,48
My instincts were to extend but was not encouraged by doctor to do so.

[Imagine]

1a
48wks
40mill
4wk UND remained so throughout tx


I thought I really had the stats going for me. I could really taste SVR. Will always wonder what would have happened if I forced my Doc to extend to 72wks.