Which test?

[Tixxy]

I tested positive for HCV antibodies, but 3 consecutive PCR RNA tests came out negative. It is thought that I had hep C but cleared it. I think I may have had a false positive as i had a lot of auto immune stuff going on at the time and read that it can affect the antibody test, and would like to retest to see if i actially have antibodies. What are my options? Another antibody test or a RIBA test? Would a negative RIBA test mean that I had a false positive? I need to find out for insurance reasons and also want to know as my health would have been impacted during the acute phase and some damage may have been done and if this is the case I may get a fibrosure test done as I have some health issues that may be liver related. Thanks

[Tixxy]

Thank you

[hrsepwrguy]

"Would a negative RIBA test mean that I had a false positive?"

Yes

Diagnostic Tests

SEROLOGIC ASSAYS

The diagnosis of HCV infection can be made by detecting either anti-HCV or HCV RNA. Detection of anti-HCV is recommended for routine testing of asymptomatic persons and should include use of both enzyme immunoassay (EIA) and supplemental or confirmatory testing with an additional, more specific assay (Figure 1). Use of supplemental antibody testing (i.e., RIBA) for all positive anti-HCV results of EIA is preferred, particularly in settings where clinical services are not provided directly.

Supplemental anti-HCV testing confirms the presence of anti-HCV (i.e., eliminates false-positive antibody results), which indicates past or current infection.

http://www.aafp.org/afp/1999/0101/p79.html