anybody have cirrhosis on biopsy with the rest of the tests totally normal?

[niceguy2007]

after reading about the palmar erythema occuring at stage 2 posted by one member here,

i was wondering if anyone on the forum has ever been diagnosed with cirrhosis on a biopsy, with:

- normal platelets
- normal spleen size on ultrasound
- no fatty liver / or some fatter liver on ultrasound
- totally normal abdomen and organs on ultrasound

??

[CitizenSmith]

Just my 2 pees worth (2 cents), I've seen comments from two of the top bods in the UK to the effect they are seeing more Geno 3 relapses than initial studies suggested.There are now ongoing studies Txing for 48 weeks with a view to preventing these relapses.Personally I think the 4 week undetectable people will be fine on 24 and if it were me I'd do 48 if not.I realise it's each individuals decision to make but we all need as much info as possible.The red palms thing is a bit of red herring :) it takes someone with a lot of experience to tell the difference between normal and cirrhotic  redness.

[Kalio1]

I also think you should seriously consider extending however I do not believe niceguy needs to extend, he does not have damage like you do. I know he worries a lot, but all his info points to him having either no damage at all or a very small amount plus he cleared it by week 4.


I too am a 3a and relapsed, my recent Fibroscan score was 11.1 which is not a whole lot more than what you have. I would extend if you can, Scuba. I would do 48 weeks if I were you. Also you have a bit of a weight issue, I'd try to lose that if possible. You dont have to eat a ton of fat with the Riba, just some to get it rolling. That aspect is important in the first part of tx but you dont have to keep up massive amounts of fat for the entire tx. How much riba are you on? I'd take the max I could get my hands on in the beginning of tx.

[FlGuy]

I'm a relapsed G3, but there were reasons that I relapsed that are not necessarily applicable to you (early cirrhosis, older than dirt, underdosed with riba, bad pcr scheduling and a few others) - almost the opposite of you.  Without a compelling reason to extend, why would you?  If anything, you might consider a shorter, rather than a longer course, of tx.  Talk to your doc.

[NYgirl]

Thank God for you - it's so nice to know my thought process isn't that off the beaten path.








hahahaha ;)

[scubadiver30]

thanks for responding...
So if I feel reasonably well the first 4 weeks that does not mean I'm not gonna feel crappy later on right?
So I guess I'll base my decision on the VL readings early on...
but the male + >40 + BMI formula is gotten me paranoid and since I'm tailoring my TX based on the experiences here, I thought it was common sense to extend :-(
Today I feel exceptionally well (except a mild riba rash) and I have found the I'm able to concentrate better and produce several good ideas at work...I wonder if my body can feel it has achieved SVR? That would be extremely cool wouldn't it? naahhh


Good luck this time

[scubadiver30]

Hi Kalio, gracias 4 your input
I'm doing 800 RIBA /180 IFN...the standard for 2b.
Tomorrow I will insist on the 48 wk. But like I said before, I have no means of getting procrit or neupogen on SS so I guess I have to be extra careful...They didn't want to give me more riba to start with.
My 10 KPA is also scary, and my 90 kg also are negative predictors... and the red palms that I never considered issues before :-(
One question, did u levelled out after the 24th week?

thanks and best wishes