Wow...that is a shame. I assume the reason is because funding for research into herbal alternatives is probably extremely low. I guess Memorial Sloan-Kettering is not in your network for your insurance. When I called they said they take Blue Cross/Blue Shield. FYI for anyone thinking of the clinical trial - the medication is free, but your insurance must cover the doctors visits and lab work. I am going to work with my GI and PCP while taking. I think $150 for 3-months (purchased online) is reasonable and worth a shot.
I have no idea about the Milk Thistle. I remember Galen posting threads that Milk Thistle may increase the level's of medication in one's blood stream, and that this can be potentially dangerous on tx (at least for treatment for HIV, and possibly tx for hep c also), but I don't know how this may apply to Sho-saiko-to. It is worth keeping in mind though.
G
I have no opinion of milk thistle or Sho-saiko-to. Dr. Seef at he NIH has spoken of this for a number of years and he has published a paper on alternative and complimentary medicine and hepatitis C (he is also a patient).I have a hard copy but haven't found an online copy yet.
My understanding is that, while milk thistle has not shown any clearcut benefit, it has not shown any harmful properties, either. At least, this is how I understand what Dr. Seef has said when I have heard him speak.
Smoking anything is a bad idea for someone with liver disease.
I have no earthly idea about the Sho-saiko-to at all and will look to the results of this trial to learn about it.
I read all the information on the site gwithhepc posted the links too. That company DOES say use milkthistle.
Hepatitis Weekly, Jan 13, 2003 p8
Sho-saiko-to extract reduces hepatic inflammation, fibrosis in nonsevere cases.
Full Text: COPYRIGHT 2003 NewsRX
2003 JAN 13 - (NewsRx.com & NewsRx.net) -- Sho-saiko-to extract, a Chinese herbal medicine commonly used for treatment of chronic hepatitis in Japan, effectively reduces liver inflammation and fibrosis up to a point. It does not benefit severe cases, pharmacologists report.
M. Kusunose and colleagues induced various stages of liver injury in model rats and administered Sho-saiko-to extract to try to determine the conditions under which Sho-saiko-to extract improves hepatic inflammation and fibrosis.
"The liver injury model rats were produced by administration of various doses of dimethylnitrosamine (DMN) and Sho-saiko-to extract was administered to these rats. Then the liver inflammation and fibrosis-improving effects of Sho-saiko-to extract were evaluated according to L-asparate aminotransferase (AST), L-alanine aminotransferase (ALT), liver retinoid levels, levels of hydroxyproline, transforming growth factor-beta (TGF-beta), and the liver fibrosis area. These indicators depended on the total doses of DMN," the researchers said.
They reported that "[t]he ability of Sho-saiko-to extract to improve liver inflammation and fibrosis was limited to the following levels of the respective parameters: AST levels (234-264 U/l), ALT levels (208-232 U/l), TGF-beta levels (1102-1265 pg/g liver tissue), hydroxyproline levels (633-719 nmol/g liver tissue), and liver fibrosis area (9.7-10.6 times for normal rat)."
Kusunose and colleagues wrote that their "findings suggested that Sho-saiko-to extract is effective in the treatment of liver inflammation and fibrosis up to a certain degree of severity, but it produces no improvement in more severe cases."
Kusunose and coauthors published their study in the Biological & Pharmaceutical Bulletin (Effect of Sho-saiko-to extract on hepatic inflammation and fibrosis in dimethylnitrosamine induced liver injury rats. Biol Pharm Bull, 2002;25(11):1417-1421).
The contact person for this report is M. Kusunose, Kochi Medical School Hospital, Department Pharmacy, Nanko Ku, Oko Cho, Kochi 7838505, Japan.
To subscribe to the journal Biological & Pharmaceutical Bulletin, contact the publisher: Pharmaceutical Society Japan, 2-12-15-201 Shibuya, Shibuya-Ku, Tokyo, 150, Japan.
The information in this article comes under the major subject areas of Complementary and Alternative Medicine, Gastroenterology, Hepatology, Chinese Herbal Medicine.
This article was prepared by Hepatitis Weekly editors from staff and other reports.
Article A96286017
I treated for 24 wks and cleared and remain clear. I had no money or insurance and got my meds from Schering free of cost. I didn't want to know what dying a slow death of self poisoning-which is what it is-the liver fails to clean the toxins from the blood and so a person slowly poison's himself w/his own body's toxins.(sub her for him, if you're feeling picky)
My liver now functions in a limited capacity so I strickly regulate the amts of toxins I put in my body. That's why I always say to choose your poisons wisely! And negative emotions are the most corrosive of all. And a joint never hurts.
I favor 'natural' and nutrional and herbal and other supplements to handle and sx's that did and do occur. I'm pro tx to kill the virus and tend to shy away from Rx's for sx's and symptoms.
B/ it ain't easy! My biggest ***** right now are trans-fats and modifies corn syrup in our food. So, I now prepare almost all my food where ever I am in the world.
And I love no drinking or doing 'class A's'.
So life can be as good as you want to make it.
Hi All !
There's not a thing I can add to this thread to help more than you all already have. It's a wonderful discussion but I'm certainly not qualified to comment.
I'm a little out of place here anyway because I feel like I barely qualified to be included as a Hep-C patient anyway having been a genotype 3a and only sentenced to 6 months of tx, but I just had to say a little about how well you are all getting along today. I'm so very glad to see this. It's almost like old times again...you know...like when everybody was just here to try to help each other, and maybe even have a little good clean fun doing it. :) Thanks to all here who have given so much!
Tosser ;o)
11 weeks post Pegasys/Copegus...still SVR !!!