pegasys versus peg-intron, side effects?

[orphanedhawk]

Hi,
   Any opinions on which treatment has less horrible side effects, pegasys or peg-intron?
   Thanks

[NYgirl]

Yeah but is anybody looking at our cars after we do?  ;)

I think I need a whole new chassis!  :)

[GrandOak]

I have not tried the weight-based PegIntron which requires mixing prior to injection.

But, I've found that the pre-filled syringes of the Pegasus are very convinient compared to the Procrit or Neupogen which I had to draw from vial into the syringe.

[Algernon]

I went to a good hepatologist at a big liver center and they suggested Pegasys for small folks.  I'm small and I'm clear after 17 weeks post--used Pegasys.  Good luck to ya.

On, and those pre-filled syringes were easy to handle.

[orphanedhawk]

Okay, I think I'll be blond about it and do the pegasys because I was born in the year of the horse.

[desrt]

As reported in the Aug 2006 Journal of Hepatology:

"Patients receiving Peg-Intron had significantly greater up-regulation of interferon-alfa response genes compared with those receiving Pegasys. Patients treated with Peg-Intron also had a significantly greater log maximum and log time-weighted average decrease in serum HCV RNA. A greater proportion of patients receiving Peg-Intron achieved a 2 log reduction in serum HCV RNA by week 8 compared with those taking Pegasys. There was an aproximately 16-fold greater exposure to pegylated interferon in the serum of patients treated with Pegasys."

or

Peg-Intron works better but Pegasys stays in your system longer making the NET RESULT the same.

Now if S-P and Roche could just get together and stick S-P's IFN-alfa 2b onto Roche's branched PEG molecule.........

[FlGuy]

PegIntron comes in (I think) 4 doses (different colored box), based on your body weight.  If you doc rx's PegIntron he'll prescribe according to your weight.   Pegasys, as mentioned is one-size-fits-all.