Aa
what's next after bocepravir/telepravir?
What comes next? Looks like a lot of stuff in the pipeline. Any magic bullets on the horizon? I would consider waiting if my liver doesn't get worse.
There are several magic bullets on the horizon :-)
Here's another link,,, I've posted this several times.
http://pubs.acs.org/cen/coverstory/88/8818cover.html
Researchers expect three waves of small-molecule drug approvals, each of which will improve HCV treatment. First, telaprevir and boceprevir are likely to be approved next year as add-ons to the current treatment regimen. The second wave, in three to five years, will bring second-generation protease blockers, a crop of polymerase inhibitors, and new classes of compounds such as Bristol-Myers Squibb’s NS5A inhibitor and Debiopharm’s cyclophilin inhibitor. Finally, researchers hope that in the next five to 10 years they will reach the ultimate goal—enough data to convince doctors and the Food & Drug Administration that the virus can be quieted with combinations of small molecules alone.
Here's another link,,, I've posted this several times.
http://pubs.acs.org/cen/coverstory/88/8818cover.html
Researchers expect three waves of small-molecule drug approvals, each of which will improve HCV treatment. First, telaprevir and boceprevir are likely to be approved next year as add-ons to the current treatment regimen. The second wave, in three to five years, will bring second-generation protease blockers, a crop of polymerase inhibitors, and new classes of compounds such as Bristol-Myers Squibb’s NS5A inhibitor and Debiopharm’s cyclophilin inhibitor. Finally, researchers hope that in the next five to 10 years they will reach the ultimate goal—enough data to convince doctors and the Food & Drug Administration that the virus can be quieted with combinations of small molecules alone.
I'm waiting for the Roche trial with a protease, a polymerase and ritanovir. It should be posted in the next couple of months.
ZymoGenetics PEG-Interferon lambda (PEG-IFN-λ, PEG-IL-29)
http://www.zymogenetics.com/products/PEG-IL.php
http://www.zymogenetics.com/products/PEG-IL.php
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