Yay Hector.. I'm so happy for you.. Cheers!!!!!
Wow Hector this is fantastic. I am so glad all your research and efforts are paying off and enabling you to participate in what is sure to be ground breaking research. I know reinfection post-transplant is a crucial issue and up to know virtually unavoidable. I hope and pray this all falls into place and you are free of this beast!
Yes, yes, yes, yes !!!!!
Can you see me jumping up and down across the bay ??
Getting a transplant AND being hep C free~ what a wonderful concept.
HECTOR!!! I am so thrilled for you-been holding my breath all this time, my son even made his special trip to the Wall in your honor---yes dearest guy you are going to do it! SOOOO happy.
Thank your son for me!
凸 (^_^) 凸
That is such wonderful news...was headed to bed when I saw your post. What a great way to end the night. Am so very happy for you!!! I know your success will pave the way for others in the future. And hope the other 39 will be successful as well!
Wow! Hot stuff. This tops off my day as well.
Good luck kid,
Wouldn't it be wonderful to have a solution to stop the recurrence of the hepatitis C virus in the donor liver? To not have to worry about developing cirrhosis and liver failure within a few years after having gone through the whole process of getting that first liver transplant. Isn't it bad enough to have one liver destroyed by the virus over 20-40 years then to have to worry about the accelerated process happening again due to immunosuppressants and steroids? This could be a huge milestone in the treatment of those receiving transplants because of liver disease caused by hepatitis C, which is the majority of transplant recipients in the U.S.
From HCV Advocate...
"Furthermore, the natural history of recurrent HCV following LTx appears to be significantly accelerated compared to that in non-LTx cases. Rather than the 20% figure quoted for non-LTx cases who may develop cirrhosis after 20-30 years, anywhere from 10 to 30% of LTx recipients with recurrent HCV have advanced fibrosis (scarring) or full-blown cirrhosis within only 5 years. Another problem is that, once cirrhosis develops post-LTx, complications occur more rapidly than in non-LTx cases. If another LTx is required, the outcome is usually not as favorable and some liver transplant centers refuse to offer a second LTx on this account.
In some instances, a particularly aggressive form of recurrent HCV develops within only a few months post-LTx and this condition has been labelled “fibrosing cholestatic hepatitis” (FCH). "
This is phenomenal news!!!!
This is great news. I am a post liver patient currently on tx. I am so happy that you have a chance to be Hep c free going into your "receiving the gift of life" tranx.. I had a living donor (my sister) and after she gave me the "gift of life" and have this virus damage that gift, seems so senseless. I can only wish you the very best. I know how sick you are and have been and it will get soooo much better. Good luck!
Congrats Hector this is great news!!!!!!!!!!!!
you deserve to live a hepc free new life Hector. Although we don't know each other was rather impressed by your life story. Wishing you all the best and hope to see you for a long long time in Liver Communities health forums. i'll pray for u.....
tears in my eyes! Smile on my face!
Wow! Haven't been on for a bit and am so glad I came on to get this incredible news. The word on the street is that the 7977 has minimal sides, so you get to kick the virus to the curb without having to endure the current triple therapy side effects. Things are really looking up for you, Hector. Very much looking forward to your first UND result, then the successful transplant news. Congratulations, sir.
From the studies I've seen with GS-7977 and ribavirin, everyone including us previous "null-responders" are UND by week 4. The problem has been when some groups of patients stop treatment, they relapse.
The nice thing about this study is there is NO STOPPING of treatment. (!) We take the treatment drugs up to and on the day of our liver transplant. We will have a viral load test at the time of transplant. Take the old cancerous liver out and put in a new shiny nutmeg brown donor liver. Put us back together and hope that since we where UND at the time of transplant, there will be no hepatitis C virus in our blood stream to reinfect our new liver.
I will also be donating samples of my explanted liver to study its genetics, the amount of GS-7977 in my liver, any hepatitis C in my liver and to look for any changes in the blood cells of my liver. They can have it. All I ask is for a photo of my 60 year old liver after they take it out.
They will also store my blood samples for future testing from all my pre and post blood draws.
The proof will be in the pudding. Or should I say my post transplant viral load tests at weeks 1,2,3,4,8,12,24,48.
This is by far my best chance to clear my hepatitis C after living with it for the last 43 years. Long enough in my opinion.
You know, I've seen plenty of sad things on this board, but I cannot think of anything right now to me that seems like better news than this thread. I'm just so happy for you.
Happy that you may soon be cleared of the virus and happy to see you ARE getting a new liver.
"I will be 1 of only 40 people in the U.S., Europe and New Zealand in this trial.
.......and with due respect..... you aren't "1 in 40". I think it's more like one in a million.
What a wonderful bit of news. Crossing fingers till then.
hector, i'm so very happy for you. no one here deserves this chance more than you. you're such an inspiration and a wealth of knowledge for all of us. good luck with your trial. may your sx be mild and your outcome be SVR. best wishes. belle
This is GREAT news!!! : ) You have helped me numerous times, with expert advice, and more than that, you have helped me to feel grounded, via your participation in this website.
If you ever need anything, I just want you to know that I am always
right here for you also~
Fantastic news Hector. It would be wonderful if you could rid yourself of the virus prior to transplant. Big smiles. Keep us updated. You know we're all rooting for you.
Always good to hear when on can tx. .
Ah, such a wonderful piece of news from you. I can imagine that you are *smiling* now! Long distance hugs and prayers coming your way. So very happy for you,
Wonderful news! I beleive that this combo has worked for me and pray that it will for you! Best wishes as you head toward health!!!