Spaceman was doing spacework so he can pay his bills!!!!!!!!!!! My input is just for thought!!
If you clear at 4 weeks your chances of svr are good!
If you don't clear at 12 weeks your chances are not good!
Those numbers are out there!!!!!!!!
I've done double and five days and extra riba and etc........ to try and give myself a good chance for svr, I'm also going to taper off for four weeks this time!!
You just gotta figure out what you think will work for you!!!! Peace!!!!!!!!!!!!!!!!!!!
Not sure if Spaceman is around, so I'll give it a shot and he can clarify/expound further. Pegasys maximum serum concentration occurs 72-96 hours post dose. So for those who take Peg more frequently than once every 7 days usually do so to maintain close to maximun concentration on a continuing basis. Further, it's an attempt to 'hit it hard early' and then subside to a more normal dosing. I think that Space's knowledge is practical for him, not theoretical. He also modulated riba before treatment and early inot treatment. He can give you details. If you search his posts you might be able to find some of his prior comments.
I am just wondering ,
What are you basing your input on not doubling dosing and taking a single shot every 5 days, and raising the riba is this from personal experience or something you read.
thanks
When I read the post I aasumed that the double peg was for the set duration of six months, which I thought might need to be adjusted based on response as you point out. Patients who have a demonstrated 'difficult to treat' history are between a rock and a tough row to hoe; they need to be aggressive but need to make it through a long and difficult regimen. Cranking up the Peg and the riba needs to be carefully monitored. As for the mixed metaphor comment, just my attempt at being peculiar.
" By the way, on of the side effects of double dosing Peg is the compulsive use of mixed metaphors."
you wrote that in your post what did you mean by that? Also redeemed is only taking the double dose for a few months then a single dose for the duration of the 72 weeks. As I understand it once his viral load reaches 0 he will probably go down to a single dose. Its very unclear how long he will do the double, it could be 2 months or as long as 6 from what the Dr. said. and you have to ask him but I think they raised his ribi from what he took the last time.
Hi Meki i see you found my dad thanks for all your help.
Redeemed - we have a couple people on the board who are HIV pos also - so -- check for them - They can help you with that side.
I don't know enough about the double dosing - but I'll send you lots of hugs - and warm wishes to make it through this.
Meki
I would ask the doctor why you need to double dose past when you get a "0" with a good test!! And at what week did you clear last time and with what test? Also I would check into doing the shots every five days instead of double all the way!! And raise riba!!!!!!!!!
Are you scheduled for a viral load test within the next couple weeks, or so? It's pretty important to know what the decline is and when you reach undetectable. The morining before you take your 3-week shots would be ideal.
i started this past friday and take both shots at same time in two different spots
Pegasys is alpha-2a, which you have and is manufactured by Roche. PegIntron is alpha-2b and is manufactured by Schering. The reading I have done tells me that they are similar in effect, which is generally proven in side by side comparisons. My experience, for several reasons, causes me to have preferred Pegasys. But also need to understand that each company sponsoors these comparisons. For more reading, go to Pegasys.com or Pegintron.com.
Have you started yet? Do you take the two Peg shots on the same day, or separated by a few days?
There is another poster here (Cirqdusoliel) who is also co-infected and may have some wisdom from his recent experience. But I don't think he did the double stuff, unless it was an Oreo.
dont understand the difference between pegasys and pegintron.my medicine box says peginterferon alfa-2a pegasys 180 ug/0.5 ml,which i take 2 shots of weekly along with 6 200 mg ribivirin daily.im also hiv positive about 20 years,on meds for that as well.if you can explain the difference in the 2 interferons,i would appreciate it,and any other feedback as well.i dont know what to expect,as this is my 2nd treatment with interferon and ribi,but my faith will carry me.god bless
Be very careful about getting your thyroid tested..........double dosing peg and 72 weeks of treatment is a big giant red flag for thyroid issues.
A few things, which are only just my opinion. It's not unreasonable to double-dose the peg, especially if you responeded slowly the first time around. In my experience, and I double-dosed for a short amount of time, I'd use Pegasys and not PegIntron. I found Pegasys to be milder than PegInton, I used both in different treatments. The double of Pegasys was less affecting than a single of PegIntron and a double of Pegasys was only about 25% more impacting than a single of Pegasys.
To say that treatment will be double-dose for a full 72 weeks seem to me to be overly simplistic. The duration of double should be monitored through the early weeks and months to deterime responsiveness and the side effects by early and frequent viral lod tests and a careful wacth on the other various blood values. Adjusting the treatment meds, based on the response, is something that needs to be discussed with the doc. That's only the Interferon side of things. The other component to consider is the riba and it's dosage during the course of treatment. To me, riba was the more impacting of the two and bears a lot of scrutiny before and during treatment. If the doc has a lot of expereince in treating more difficult cases he'll probably be aware of some of these subtlities to give you the best chance. One other thing to keep in mind is insurance challenges. Peg is wildly expensive and you insurance co. may take a dim view of covering all those expenses. So, before you go down the whitewater rapids of double dosing you should have all your ducks in a row. By the way, on of the side effects of double dosing Peg is the compulsive use of mixed metaphors.
you will be fine.. Just chin up and have Faith
There is a woman who comes here occassionally, Oceanliver, who was double dosing. They had her do that because she was a slow responder.
Good luck.