Aa
FibrospectII - can someone interpret?
I have been reading and posting on this forum since I found out I had HCV; first doctor ordered Fibrospect II test thru Prometheus Labs. Results showed:
FibrospectII Index 69
Consistent with metavir F2-F4
Liver panel blood work all came in "normal" ranges
My current doctor told me that no biopsy was ordered due to genotype (2b) and she said that this test was good in showing NO damage, or SEVERE damage
My question is: I read about Fibrosure, Fibroscan, etc. Are these the same as Fibrospect? I read about liver damage being FO or F1, but I don't see anything about F2-F4. On my test results, it also says "these values will vary with prevalence of F2-F4 fibrosis".
I'm at a loss as to what those initial scores actually mean, or else my memory/brain function is just not up to speed, after treating for the 6 months.
Thanks to All.
FibrospectII Index 69
Consistent with metavir F2-F4
Liver panel blood work all came in "normal" ranges
My current doctor told me that no biopsy was ordered due to genotype (2b) and she said that this test was good in showing NO damage, or SEVERE damage
My question is: I read about Fibrosure, Fibroscan, etc. Are these the same as Fibrospect? I read about liver damage being FO or F1, but I don't see anything about F2-F4. On my test results, it also says "these values will vary with prevalence of F2-F4 fibrosis".
I'm at a loss as to what those initial scores actually mean, or else my memory/brain function is just not up to speed, after treating for the 6 months.
Thanks to All.
You Albumin looks just fine. Albumin in a well nourished person without kidney or liver problems should hover around 4 or above.
Now you look at you platelets, bilirubin, and pro-time (INR), have an ultrasound of your liver with spleen size measurements, which should be below 12, preferably around 10 cm, and if all checks out well, repeat Fibrospect next year.
Fibroscan (which measurers liver stiffness) should come to market in the near future, and you want to consider that test as well.
Sorry, I read very little here these days, and don't know your story. I just come by to look for old timers and how they are doing.
Ina
Now you look at you platelets, bilirubin, and pro-time (INR), have an ultrasound of your liver with spleen size measurements, which should be below 12, preferably around 10 cm, and if all checks out well, repeat Fibrospect next year.
Fibroscan (which measurers liver stiffness) should come to market in the near future, and you want to consider that test as well.
Sorry, I read very little here these days, and don't know your story. I just come by to look for old timers and how they are doing.
Ina
records I have for blood work date back to 1999; Albumin 4.5 in 1999
2001 it was 4.5
2003 it was 3.7
2006 it was 4.3
2007 end of treating 4.1
2001 it was 4.5
2003 it was 3.7
2006 it was 4.3
2007 end of treating 4.1
A score of 69 puts you into later stage 3.
At 69 the specificity is between 87 and 92 %, and the predictive value of results is between 83.8 and 86.8 %.
And yes, stage 2 and 3 can be somewhat inaccurate.
Your Albumin, platelets, bilirubin and INR can complete the picture fairly accurate.
Being in the normal range of any of the above is not enough. For example, having an Albumin of 3.6 is still normal, but certainly indicates trouble.
You need to look at old records, 10 years or so ago, to see what was normal for YOU.
Unfortunately most people don't keep records that long, they trust their doctor......everything is normal,
Ina
At 69 the specificity is between 87 and 92 %, and the predictive value of results is between 83.8 and 86.8 %.
And yes, stage 2 and 3 can be somewhat inaccurate.
Your Albumin, platelets, bilirubin and INR can complete the picture fairly accurate.
Being in the normal range of any of the above is not enough. For example, having an Albumin of 3.6 is still normal, but certainly indicates trouble.
You need to look at old records, 10 years or so ago, to see what was normal for YOU.
Unfortunately most people don't keep records that long, they trust their doctor......everything is normal,
Ina
I'm not an expert, but I know FibroSpect II is not very accurate in the "middle stages". I had a score of 60 and my biopsy came back as a Stage 1- very little damage. I was so happy! So if you really wanna know how much damage your liver has, I'd recomend a biopsy. I see you've already treated- congrats on being UND!!! Without the Hep C, your liver won't keep getting damaged- in fact many times the damage is reversed to a certain point. So I think many people inyour situation would forget about the bx.
Best of luck whatever you decide!
-Dee
Best of luck whatever you decide!
-Dee
thank you both for your comments.
NYgirl - I probably will not have a biopsy, since I just completed treatment; my 6 mo PCR is due in January 08. Pre-treat VL 1.8 Mil, over 4 log drop/ 135 at 3 weeks; 8 week PCR was UND; after last Interferon shot, VL was UND.
Jim - my extensive blood work and ultrasound pre-treating were all good. All during treatment, my blood work was okay. WBC and RBC were low due to drugs, but I never did require anything else. My CBC 5 weeks after tx was really good (blood counts back to normal etc.)
Thank you both again.
NYgirl - I probably will not have a biopsy, since I just completed treatment; my 6 mo PCR is due in January 08. Pre-treat VL 1.8 Mil, over 4 log drop/ 135 at 3 weeks; 8 week PCR was UND; after last Interferon shot, VL was UND.
Jim - my extensive blood work and ultrasound pre-treating were all good. All during treatment, my blood work was okay. WBC and RBC were low due to drugs, but I never did require anything else. My CBC 5 weeks after tx was really good (blood counts back to normal etc.)
Thank you both again.
As your doctor suggested, Fibrospect II is most accurate at the two extremes. Since your score appears to be in the middle, I don't think you can take much from it other than you're probably not FO or F4. Needle biopsy and/or Fibroscan would give you more useful data if you want to pursue. Also, a good clinician can make some sort of assessment based on other blood tests and procedures.
-- Jim
-- Jim
I just wanted to tell you you aren't being ignored....I have never had any Fibro and can't interpret the results cause I don't know what they mean. Most of us have had the biopsy which is much more reliable. I'm a geno 1A and a geno 1B so I really needed to have it and although I never had any symptoms at all it turned out I am stage 3 liver damage...so I was glad I had the test.
Most geno 2s don't have a biopsy although if you want one I'm sure you could have one just to make sure what your liver damage is?
Someone will come in who knows what it all means, I'm just sorry I don't and can't help you.
Most geno 2s don't have a biopsy although if you want one I'm sure you could have one just to make sure what your liver damage is?
Someone will come in who knows what it all means, I'm just sorry I don't and can't help you.
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