GS-7977 and Ribavirin Clinical Trial

[HectorSF]

I found out today I AM UNDETECTABLE after 2 weeks of treatment with GS-7977 and Ribavirin.

Not bad for a previous null-responder to peg-INF and Ribavirin where after 12 weeks of treatment my viral load never went below 360,000.

"An Open-Label Study to Explore the Clinical Efficacy of GS 7977 With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant"  ClinicalTrials.gov Identifier: NCT01559844

During screening my viral load was 1,200,000
On day 1                                         692,000
1 week                                                   581
2 week                                                   <25

COBAS TaqMan HCV Test
week 1 dropped 3.06 logs
week 2 dropped 4.44 logs

Cheers!
Happy
Hector

[rivll]

The reason no one believes you is that you are incorrect.
True, people have different responses. Some people don't suffer from serious side effects. However, you cannot make a blanket generalization based on your personal experience.

[8nickers8]

Hector request all 24 weeks.  Also, I have a favor to ask.  I don't know if you remember but I just did my own Heptimax just so I could see the VL with my own eyes and 9 weeks Post Treatment I am UND.  I go on Monday for the 12 week post treatment blood test but it is a double blind study so I will not get the results but I believe, based on what has happened so far, that if anyone relapses, they will be pulled from the study as happened a short while ago.  I am so scared.  I wonder when this terror will end and I will relax. Maybe at 24 weeks post.  ANYWAY - I have a favor to ask of you.  Now that you are doing the same treatment that I did, 7977 and riba and I had no side effects except for the hemoglobin dropping but they gave me the supplements and that took care of that.  I realized in retrospect that I was more emotional during those 12 weeks and a bit angrier than my normal self but nothing that was outrageous.  SO would you please confirm for everyone that ribavirin is an easy drug to take and it has no terrible side effects the way people have been saying it does.  The only time that happens is when it is taken with Interferon.  Truly, of all the people on the study with me, NONE of us had any side effects to speak of.  Can you please confirm that because no one seemed to believe me.  Thank you.

[dointime]

Gosh this is such an exciting trial!  You must be over the moon to have got on it.  How interesting that you are a CC.  Thanks for posting,
dointime

[HectorSF]

"How many weeks are they planning on giving you the medication?"
24 weeks or until I get a liver transplant whichever is first.
SVR for this treatment is 12 weeks after end of treatment. Or 12 weeks after transplant.

I forget what genotype you are but if you are type 1 I'd want all 24 weeks.
Good question! I am genotype 1b. I am also IL28B C/C. Even though I was a previous null-responder to peg-INF and Riba treatment. So much for C/C predicting response to interferon in all people.


Hector (Nice to be undetectable after 43 years of infection)

[coraggio]

It is truly amazing to know that GS-7977 has the ability to bring someone with a ravaged liver down to an undetectable level in 2 weeks.  It's incredible stuff when compared to SOC and even the PI's, which can be long a brutal treatments.  

Congrats HectorSF, wish you the best.

[slideman]

You are the man!! I am so happy for you. If anybody deserves good news its you......and all of us that you have helped for so long. You must be on top of the world!! Good luck my friend and I will be praying for more good news from you!!