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Re-treating -got brain fog?
Cognitive function does not worsen during pegylated interferon and ribavirin retreatment of chronic hepatitis C.
Fontana RJ, Bieliauskas LA, Lindsay KL, Back-Madruga C, Wright EC, Snow KK, Lok AS, Kronfol Z, Padmanabhan L; HALT-C Trial Group.
Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-0362, USA. ***@****
Treatment of chronic hepatitis C with pegylated interferon (peginterferon) and ribavirin can cause or exacerbate depression but its effects on cognitive function are largely unknown. The aim of this study was to determine whether treatment with peginterferon and ribavirin adversely impacts cognitive function in patients with chronic hepatitis C. Prior nonresponders to interferon were retreated with peginterferon alfa-2a and ribavirin for 24 (n=177) or 48 weeks (n=57) in the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis trial. Cognitive function was prospectively assessed using a battery of 10 standardized neuropsychological tests at weeks 0, 24, 48, and 72. Cognitive impairment was defined based upon a global deficit score. The Beck Depression Inventory and Brief Symptom Inventory were used to assess mood status. The 57 subjects who completed 48 weeks of antiviral therapy reported significant increases in difficulty concentrating, emotional distress, and symptoms of depression, all of which improved after cessation of therapy [P<0.0001, analysis of variance (ANOVA)]. Nonetheless, the frequency of cognitive impairment did not increase during the first 24 weeks of treatment in 177 patients (34% versus 32%, P=0.64) nor in the 57 patients completing 48 weeks of treatment (P=0.48, ANOVA). CONCLUSION: Retreatment of prior non-responders with peginterferon and ribavirin was not associated with objective evidence of cognitive impairment as measured by a comprehensive battery of neuropsychological tests. The lack of cognitive impairment is reassuring and suggests that self-reported symptoms of cognitive dysfunction are more likely related to the systemic and psychiatric side effects of antiviral treatment rather than measurable changes in cognition.
Mike
Fontana RJ, Bieliauskas LA, Lindsay KL, Back-Madruga C, Wright EC, Snow KK, Lok AS, Kronfol Z, Padmanabhan L; HALT-C Trial Group.
Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-0362, USA. ***@****
Treatment of chronic hepatitis C with pegylated interferon (peginterferon) and ribavirin can cause or exacerbate depression but its effects on cognitive function are largely unknown. The aim of this study was to determine whether treatment with peginterferon and ribavirin adversely impacts cognitive function in patients with chronic hepatitis C. Prior nonresponders to interferon were retreated with peginterferon alfa-2a and ribavirin for 24 (n=177) or 48 weeks (n=57) in the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis trial. Cognitive function was prospectively assessed using a battery of 10 standardized neuropsychological tests at weeks 0, 24, 48, and 72. Cognitive impairment was defined based upon a global deficit score. The Beck Depression Inventory and Brief Symptom Inventory were used to assess mood status. The 57 subjects who completed 48 weeks of antiviral therapy reported significant increases in difficulty concentrating, emotional distress, and symptoms of depression, all of which improved after cessation of therapy [P<0.0001, analysis of variance (ANOVA)]. Nonetheless, the frequency of cognitive impairment did not increase during the first 24 weeks of treatment in 177 patients (34% versus 32%, P=0.64) nor in the 57 patients completing 48 weeks of treatment (P=0.48, ANOVA). CONCLUSION: Retreatment of prior non-responders with peginterferon and ribavirin was not associated with objective evidence of cognitive impairment as measured by a comprehensive battery of neuropsychological tests. The lack of cognitive impairment is reassuring and suggests that self-reported symptoms of cognitive dysfunction are more likely related to the systemic and psychiatric side effects of antiviral treatment rather than measurable changes in cognition.
Mike
Nice to see you fishy...
I guess we all get it different - but one year later and my mental situation is still improving, one bit at a time.
Master Naturalist Program: Friole, ain't those the people who run around outdoors with no clothes on?
I guess we all get it different - but one year later and my mental situation is still improving, one bit at a time.
Master Naturalist Program: Friole, ain't those the people who run around outdoors with no clothes on?
Belive me, mr goof man ya don't want to see this bod nakid!
fish - let's put a call in for candoman. This should be his last Riba at regular dose.
bean
fish - let's put a call in for candoman. This should be his last Riba at regular dose.
bean
Hey Mike, not aiming the BS at you, but at the scientific approach of studying mental functions........that stuff is not hard science (as opposed to soft science)........where's the can man when I need a quip!!! I think the main brain issue is the inability to focus, something like temporary ADD. When someone put me on the spot and asked a tough question......my brain would eventually pull it up......but as far as sitting down all day and writing proposals or manuscripts.......forget it....so how are you doing these days anyway?
Hey Friole, yes, I'm still here, headed to town today...PCR time...as you probably know..I don't have a good feeling. Had a guy stop by yesterday that is trying to get funding to captively rear PC. Its feasible because they are not state listed yet (duhhh I wonder why?? did I mention oil fields..)
Goofers...how are things going for you? My brain is slowly coming back..I can't remember if you were going to retreat or not?
Wheres beemer, and what are his results so far??
Hey Friole, yes, I'm still here, headed to town today...PCR time...as you probably know..I don't have a good feeling. Had a guy stop by yesterday that is trying to get funding to captively rear PC. Its feasible because they are not state listed yet (duhhh I wonder why?? did I mention oil fields..)
Goofers...how are things going for you? My brain is slowly coming back..I can't remember if you were going to retreat or not?
Wheres beemer, and what are his results so far??
I wasn't offended at all - that's my weird sense of humor. You said: "I think the main brain issue is the inability to focus, something like temporary ADD." I agree but what interested me was the idea that this could be attributed, in whole or in part,"to the systemic and psychiatric side effects of antiviral treatment rather than measurable changes in cognition." But, it probably doesn't really matter why we become less functional as long as we recover whatever cognitive ability we had prior to treatment when we discontinue the drugs.
BYW, I am feeling good and my labs are good. I am waiting for Heptimax results from a draw on Wednesday but I am not really worried. I should have them later today but I will be clear - I hope. Mike
BYW, I am feeling good and my labs are good. I am waiting for Heptimax results from a draw on Wednesday but I am not really worried. I should have them later today but I will be clear - I hope. Mike
About those Prarie chickens ---- No, those Prarie chicken were in Yoakum Co Texas (kind of SW from Lubbock). (They don't even come as far south as Midland, much less the Bend). It was a field trip for the Master Naturalist Program program I am taking (a program I started AFTER TX , I might add - there was no way my brain could absorb anything new not hep c related during tx -(that ties this into this thread, ha ha)). We heard a Praire Chicken expert with the TPW ( who is supposed to be writing the conservation plan for them) speak too. They are concerned about the wind farms popping up all over the place and have determined that one per 160 acres is all a ranch can sustain. Prairie chickens don't like noise OR high objects. They are cool dudes - stutting their stuff and I will never forget the booming sound.
Last week with the Master Naturalist program we went to another ranch that had a wind farm, and I tell you, I have never seen so many wind generators. No way they will keep those to 1 per 160ac - especially w/ damages plus $5000 per year rentals per unit!!!!
bean
Last week with the Master Naturalist program we went to another ranch that had a wind farm, and I tell you, I have never seen so many wind generators. No way they will keep those to 1 per 160ac - especially w/ damages plus $5000 per year rentals per unit!!!!
bean
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