Boceprevir News(April 25-2009)

[Rockerforlife]

analysis revealed that patients who developed anaemia (haemoglobin <10g/dL) had higher SVR rates compared with patients who did not develop anaemia.


not good news for me as my HMG is sitting at around 11.0...im eating hihg fat foods with my Riba and im at my normal weight...190-200 lbs....i still am in the ball park tho....i did get the RVR  at week 2 after recieving the BOC



http://www.docguide.com/news/content.nsf/news/852571020057CCF6852575A300723B3D

[Rockerforlife]

Sorry bout that.i went off track on the VL ,yes,i did get RVR and my HMG did have the substancial(spelling) drop from 16 to 11....the perfect HMG # would be 10,but ya cant have it all...i was just thinkn...if i do get SVR....i wont be as happy as i would if i didnt lose my job...i know one thing tho...if i get my career back on line and i SVR....you will hear my scream from up here in great white north

[epiphiny]

Umm, I think we are talking about two different things. I was taking about hemoglobin drop which causes anemia rather than the drop in viral load cos I got confused and thought this was a thread about SVR and anemia!  Either way, you got RVR,AND your hb levels have dropped substantially from it's baseline.

[Rockerforlife]

its almost like a real fight with a human....you need the knock out punch to win

[Rockerforlife]

Its hard for me to explain....in a nut shell you need the < 10 COPIES ....by one month...it dont matter if you have a baseline line of a trillion of 500 hundred ....its getting it down fast ...hard    and keeping it there

[Rockerforlife]

II thought it was how far you dropped from your base level that was the indicator?

NOPE...main thing is how  fast you clear, which determines SVR....ITS not the amount of the drop....its the speed

[epiphiny]

I thought it was how far you dropped from your base level that was the indicator?  And also anemia is defined differently for men and women, is it not?  I would say from your baseline level to your current level your hb is low and no doubt considered clinical anemia in a male but not so dangerous that you require a rescue drug.

Also, I'm with everyone else that says you got RVR, supposed to be the trump card, right?  Hang in there Rocker, you are doing great!

Epi x

[Rockerforlife]

Ill bet you my life if you do the Boceprevir TX ,you will beat this once and for all....the PI/combo is the ticket....after the nubers are crunched after my trial....look out....the drugs will hit the street and be sold out like hot cakes

[susan400]

Well, I have some of those statistics in my favor..., I'm female and I've on the thinner side of normal.   But, so far, neither of those have helped me out much.....  

Still Geno 1A,    lost the 1B...        

Got the PI, but missed the 2nd half of the SOC when I wasn't given the Riba.

One of these days, every thing will work out for me to get there...., if not, I'll just make it to heaven sooner rather than later and then, I'll still be a winner!!   How's that for positive thinking?

Susan400

[Rockerforlife]

WASHINGTON (AFP) – The US restaurant chain T.G.I. Friday's has asked the New York State Police to open a criminal investigation into suspected product tampering after a severed snake head was found among vegetables



http://news.yahoo.com/s/afp/20090510/od_afp/ussocietyrestaurantsnakeoffbeat;_ylt=AnE1hMsvteEQpTGR06Dt1uoHcggF

[Rockerforlife]

I guess the best odds go to females...skinny...young...low VL...Geno 2/3....RVR...on the PI/Combo....if you fall into this grounp...you are one lucky lady

[comeagain]

I think newleaf  is thinking clear here don´t you worry!!

I`ve always heard that RVR knocks out every other circumstances regarding SVR achivement, such as old age, high BMI, male gender, high baseline vl, rase, yes everything.

And this isn´t new there has been other studies years old leaning in that direction that the more anemic the more likely you are to respond to the meds well but you allready have responded and you can´t respond better than RVR.

ca

[newleaf09]

Now that I am so deep into tx, I've just stopped reading the studies.  What can they predict for people like us who cleared early on triple therapy anyway?  There will be a whole new set of stats and recommendations after they crunch the numbers from our Schering studies.  This science is now moving very fast and the studies get disproven almost as fast as they are published.  We are 'on the road' now regardless of what any study says..

[Rockerforlife]

My HGB is holding at 11.0....baseline was 15.8

[newleaf09]

Schering is getting knocked for causing more anemia with boceprevir than SOC drugs alone.  They author is just trying to put a positive spin on boceprevir-induced anemia.  Try not to be alarmed by it.  I'm ignoring it.

[Rockerforlife]

The report does not state the % of those numbers either...im willing to bet im SVR now....with a 82-94% chance i have been given...if i dont SVR ...i guess my lucck will have run out...because in my past i have been very fortunate...i may only have 9 mores shots to go....or 21....depends on the arm im assigned to....



analysis revealed that patients who developed anaemia (haemoglobin <10g/dL) had higher SVR rates compared with patients who did not develop anaemia.

[susan400]

This study is a bit of a mystery to me.  If having anemia is a good indicator of an SVR, then I should have been an SVR on any one of my treatments as I always ended up with anemia after about the 1st mon., except on the 1 TX that I did where my doctor pre-emptively started my TX off from the beginning w/Procrit.  So, why wasn't I SVR?  Who knows?   I wouldn't worry about it too much because you may just be SVR regardless of the fact that you aren't anemic!!!  Keep the faith!   Susan400