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Acyclovir - length of episodic treatment?

I have been prescribed 5 x 200 mg acyclovir/Zovirax a day when I have a facial HSV outbreak. The prescription and drug info says to continue treatment for 5 (to 10) days, but often the outbreak is gone within 3 days.

My doctor couldn't provide the arguments for continuing the treatment for the full 5 days even though the OB is gone. Does anyone know???
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101028 tn?1419603004
Well that answer doesn't really give you an answer now does it? lol  That's a cya answer if I ever saw one!


Go with the dose I recommended. It's easier to take and works the same way as a full 5-10 day course.  I really do know what I"m talking about :)  When it comes to herpes you want to hit it hard and fast - the number of days isn't the issue as much as the dose is.

grace
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Avatar universal
Believe it or not, I actually got an answer on this from GlaxoSmithKline (makers of Zovirax).
Translated into english, their answer this:
"If the treatment is too short, the disease may reactivate since the symptoms can dissappear a few days before the infection is really gone. It is exactly as with antibiotics; the prescribed treatment must be completed even if you are feeling better after a few days, to make sure the infection does not come back"
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101028 tn?1419603004
The amount you were prescribed is for a first herpes ob ( the full 10 days ).  It's not a recurrence dose.

The easiest way to use acyclovir for oral herpes is 800mg 3x/day for 2 days.  It's not FDA approved as a dose but the literature backs it and it's become generally accepted as a dose ( acyclovir has been a generic for a long time so it's doubtful anyone is going to pay for the studies to go for fda approval of this dose ).  I will gladly share the journal article citation for you if your provider wants it ( they can look for it themselves!!! ).  

grace

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