I am on 200 mg prometrium /5 mg estradiol, and metformin as well as tirosint. The prometrium and estradiol is for hot flashes. The metformin for prediabetes, couldn't get my a1c down, and tirosint for thyroid disease. My question is this...the prometrium and estradiol are causing my blood sugars to stay high, as well as make me very tired, as well as making me gain weight. I walk briskly at least 1 hour to 1 1/2 hour daily. I watch what I eat, low sugars, etc. I'm very active, watching my 18 month old grand daughter, I'm NOT a couch potatoe. I am feeling so out of balance! Any suggestions? I know that the estradiol can block the intake of my tyroid meds. I'd like to go off of the prometrium and estradiol, but fear the severe hot flashes will come back...and I can't sleep with those. If I do go off of the prometrium and estradiol, how do I do that...cold turkey?