Sertraline and Anxiety?

[angrydook]

I'm a 30yr old male. I was on Sertraline approx 10 years ago for depression and it seemed to work until a crash. For one reason or another over the years, my treatment has changed several times. It is 2011 and i have found my way back to sertraline. I am currently taking 10mg of buspirone 2x day and 15mg of mirtazapine for major depression and generalized anxiety.  I have been feeling constantly tired, apathetic and despondent. My psychiatrist prescribed a starting dose of sertraline of 50mg/day. Since starting the sertraline again i have been suffering from physiological anxiety symptoms such as a tight throat, lump in throat, trouble swallowing and breathing, etc.

Is there an existing drug interaction between Sertraline and Buspirone and/or Mirtazapine  ?  Or can a person's toleration of a drug change over time?

I am also dependent on imovane/zopiclone to be able to sleep.  

Please help.

[Peter Forster]

Well certainly if you are bipolar then the effects of antidepressants are going to be different, and in that case combining sertraline and mirtazapine might be a bad idea.

[angrydook]

I've been on the sertraline for about 2 weeks.

[looloo141]

Oh yes I agree! I'm not even allowed 1 anti d now. No matter how serious or long lasting the depression is..
I was just trying to explain how certain meds don't help me now but they did 12 years ago..
I think mental illness does evolve over the years, just like our lives, not much stays the same
..and we learn different coping methods, whether they are good or bad.

[looloo141]

I used to tolerate Sertraline in my 20's but a few years ago I was started on it again, it made me feel tense, agitated and I lost my appetite. I told my pdoc who was not happy that my general doc had put me anti depressants, because I am bipolar..he took me straight back off them..so i only had about 10 days on them, maybe the side effects would have stopped after another week or so..
I tolerated them well in my twenties but I'm not sure if it was because of the other meds I was on...or it could be that I didn't have chance to think about it as much as I so now..I never challenged my pdoc, I was very trusting, I got my prescriptions and just took the meds...whereas now I like to know everything..maybe its mind over Matter..

[Peter Forster]

How long have you been on the sertraline?

Those medications are commonly prescribed with each other (not all three but each combination of two is pretty common) and there do not appear to be common or significant drug interactions (except that all three can cause sedation).