Aubagio

[mayperl]

why are we not talking about this yet?  Just curious if anyone is scheduling to get a script with their dr. or if they have concerns with its side effects.

What are everyone's feelings and thoughts on this pill?

Honestly, it had completely bypassed my radar as I was only aware of BG12.  When it hit yahoo, I remember feeling shocked like, wth is this?  News to me.  Hmm.

Anyway - the stodies and trials don't appear to be impressive especially when they are comparing it to Rebif, but I have only read one site (NMSS.org).

Does anyone else here have other information?

http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=6864

[SamboleeSandra]

My doctor just recommended that I switch over to Aubagio. I've been on Copaxone for 2 1/2 yrs. but have developed severe skin issues - ulcerations at injection sites & continual peeling of skin on hands & feet. Excited I wont't have to give myself injections anymore but nervous about the newness of this medication.

[Ldusms2]

So are you still taking Aubagio? Any side affects?

[colby312]

i started aubagio a few days ago. i am feeling pretty nauseous & i got light-headed at the gym today. hoping it will pass soon. i was on rebif for years & was developing scar tissue at the injection sites. a pill seemed like a good idea. i'm still not sure. i'm a single mom of a preschooler so it's hard to be sick.

[byyygrace]

I've been taking the 14mg tablet of Aubagio for about a month now. I really haven't noticed any side effects. Every time I shed a hair I begin to wonder "will it all fall out?"! I think I'm just a little paranoid, but so far, so good!

I'm told that the liver test are for the first 6 months. I'll see my Neuro Jan. 9 and will keep you all updated with any news if you'd like.

Merry Christmas!

[Lulu54]

do you maybe recognize this drug as teruflunomide?  Aubagio has a very strong FDA boxed warning about this drug, including a pregnancy test must be given before starting it and women of child bearing age must be on birth control.  Liver function is also closely watched with this one.

There are so many new MS drugs in the pipeline, it is getting hard to keep track of which one is which. ......

[mayperl]

good point, Shell!  Those thoughts didn't even occur to me.  What exactly is being blocked and what are is the feedback from participants in the studies at the end of the trial?  If it's still going on, what is the feedback after the 2-year follow up?  That would be nice to know.   The good and... not so pleasant.

[sllowe]

Heck - I've been so out of touch lately, I didn't even realize you posted this! I just added the MS Society announcement and then saw your post here.

We should be talking about it for sure. I would like to read more about the mechanism by way this med works. And, then decide if I'd like to try it. When they start talking about blocking certain immune cells, feel I've got to do my homework. Make sure they don't block something major that can't be "unblocked." If you know what I mean.

-Shell

[doublevision1]

My neuro offered me a spot in his clinical trial of this drug but it was not feasible given the frequency of follow ups and the distance I live from the clinic.

[mayperl]

I agree, it's attractive being a pill, but still having to monitor and test for liver damage with rebif just the same - if the stats are not reducing relapse rate better than rebif why switch. The hair thinning is a bit of a vanity that I might consider compromising if there were a benefit, but ... Well, I'm just not understanding the point. Maybe there are some who are allergic to the injections that could benefit from the pill instead?

[MeSsy27]

Hi, I was so happy to read the news but, I'm currently on Rebif, so I don't see a reason to switch, only thing is no injecting..... And rebif does not have the hair loss, and fatal liver damage warning .... :/

[debgen]

I found out some interesting things about Aubagio:
- prevents relapses 30% which is similar to other DMD's, however Gilenya reports 55% prevention
-side effects:
- hair loss, nausea,diarrhea
- potential fatal liver problems
- birth defects- not to be used during pregnancy and women taking this drug MUSt be on birth control

I really haven't heard from anyone taking it. My neuro has never mentioned this one to me. It has just recently been FDA approved.

Hope this helps!
Deb

[JaneK1975]

I was wondering the same thing this morning. I read about it and it was totally new news to me - I'd never heard the name Aubagio before. I'm interested to hear others' thoughts...