C and S Protein?

[sllowe]

Hey All,

Just throwing this out there.  After my allergic reaction subsided, I decided to move forward w/flags from my lab workups in the past.  One of those followups was w/a hematologist for prolonged PT times.  Well, that has resolved for now.  I need to stop smoking, and it will probably stay resolved.  

Posting this subject to the board today, because something else has popped up.  I'm deficient in C and S protein.  Which would make you more succeptible to blood clots if I'm understanding correctly.  She said I really didn't fit the bill as I'm not on birthcontrol, chemo, and some other factors.  She has run the test again to see if it was a fluke.  I thought about it for a couple seconds while at the appt. and did mention to her that I was on DMD Rebif which is an immunmodulator.  Of course most Drs you go to don't know much about these meds. The C and S protein that flagged was run in May, and I was off the Rebif mid Feb, close to 3 mths afterward.  So, it will be interesting to me to see what the 2nd test (July) says.

I'm bringing this up because there are so many labs that are not run prior to starting DMDs. So, really, how is one to know, let alone the Drs what has or has not been affected, except from the norm - - CBC and liver enzymes.

It concerns me.  Not enough to not go on meds for MS, but just the simple fact that - no, the interferons are not suppressants, however, they modulate. What is the fine line? I'm sure I will never know if I were deficient in these proteins in the past.  But, if the new test comes up w/in range, this is something I am surely going to make sure is run from time-to-time.  What I know for sure is I don't want any part of blood thinners for the rest of my life.

What I also found out in my quest a few months back after the allergic reaction is that I have nodules on my thyroid.  I have no-way of knowing if they were there prior to meds since I did not have a ultrasound prior to starting.  None of my thyroid labs ever flagged in the past. And this was ordered much afterward due to my throat problems just as a precaution.

So, it's a chicken or the egg question in the end, but throwing this out there for discussion. . . .And, to see if anyone else had any flags w/the C and S protein.

ttys, hope all had a good weekend. Finally, some of the humidity backed off here today on the east coast, and it's sunny, and lovely
see ya's soon,
Shell

[sllowe]

Dbarber and Chelle,

This was last years convo but thank you for responding....  This is a good reminder to me that I have to revisit the issue again w/the hematologist -  shame on me, I've not gone back to find out.

ttys,
shell

[michelleric]

I have Protein S Deficiency, as well as about 4 other blood clotting factors. (lupus anticoagulant, factor 5 and a few I would have to go look through my papers for the "technical" name).

I have been on coumadin for almost 3 years, after having 2 clots after a surgical procedure.  I will be on coumadin for the rest of my life, unfortunately.

So, for me, this had nothing to do with DMD's which, most likely, I will be starting in a couple of weeks.

Life sure can be full of "stuff" sometimes,

Good luck to you Shell,

Michelle

[dbarber65]

Long time here with Protein S Deficiency....It is an inherited abnormality.  Everyone in my family that has thrown a blood clot has all done so in their mid to late 30's....i was 33, I am 44 now.  My brother was tested and is positive for PSD but my sister is not.   I had bilateral pulmonary embolisms and have been on 12 milligrams of  Coumadin since.  My brother how ever has not thrown any clots and the doctors have not put him on any type of anticoagulant.  He does take 81 mg of asprin a day just to be on the safe side.  

[DeeDee1980]

I too got tested...I have had 3 miscattaiges and seeking help from a fertitlity doctor.  After running blood test they found I had high levels of Protein C, which I will be going for a second test this weekend to see if first test was accurate.  WHat medications are out there?  And is it cureable?

[Momzilla]

Boy, that is really weird.  This will have to be one for Dr. Q (and SB, the unfortunate expert!!!!).  I Googled around a little bit, and it looks like these deficiencies can be congenital, but that doesn't really make sense, right?  How weird.

I'm interested to hear what comes of this.  Good luck, and feel well.  Let us know what turns up!

Z*

[slightlybroken]

I just got tested for this same thing because of the family history of blood clots (my mother had multiple episodes of DVT) and I just got them as well. My blood test aren't accurate right now because of the blood thinners. I do believe that there is some kind of connection whether it be the proteins or factor 5 or something. A doctor once told me that having an autoimmune disease can contribute to your blood being too thick.

I don't blame you for not wanting the blood thinners. I hate being on it but it's necessary evil. My blood did go too thin and it was a very scary experience. The vitamin K shot they gave me in the ER did not even take effect right away. That's probably because that Coumadin stays in your system for from days to weeks from stopping it.

Having those proteins can put you at risk for blood clots. You might want to consider taking a baby aspirin a day if you don't have any problems with ulcers or stomach upset. I have to watch what I eat with vitamin K because it thickens your blood. I can eat stuff like big leafy vegetables but I have to watch my intake to make sure I don't over do it on the vitamin K because it will mess with my Coumadin levels (It will make my blood thick).

I have problems with nodules on my thyroid too but my thyroid works fine. That can contribute to your throat getting that bunched up feeling. I don't think that you not eating as well as you should would contribute. I think you get things no matter what you do.

[sllowe]

Oh, one more thing. . . .
  One of the things I also read about this deficiency is ref. nutritian and vitamin K.   I have had so many problems w/my throat and the bunched up feeling that I've not always eaten as well as I should.  Think that is a contributor too?

thanks,
Shelly