MEDI-551

Question

Hi everey one, I`m new and from Sevilla, Spain. Did any of you on a trial whith MEDI-551, 
I´`ve SPMS  and I´`been informed to try one
Thanks

kwarendorf · Accepted Answer

Hi Bruno - 

Is your Doc talking about getting you into the trial? My worry about trials is that if they are properly set up, I might get a placebo, rather than the drug. 

We all respond differently to different drugs. For me, I was on Tysabri, but after a year and a hals it stopped working. Since I've been on rituximab I am not any better, but I have not gotten any worse. The goal of these drugs is to keep you from getting worse. THey aren't really designed to make you better.

Kyle

Ddelacova · Answer

Hi every one
I`ve started last monday whit first infusion of MEDI-551, 600 mg, and to the moment no effect. The next infusion will be on 2 july. I`ll wrote any nwes

kwarendorf · Answer

I guess we'll find out :-)

Ddelacova · Answer

Hi Kyle
Yes I´ll get into a trial whith the risk I´´ll get placebo instead the drug, 1 vs 4, but I don´t have another option. At less, is medi-551 is better than rituxaximab.....................

Ddelacova · Answer

The purpouse of this trial is to get a drug only for MS not than rituximab for autoinmune diseases

Ddelacova · Answer

Hi Kely
The doctor talk me that this drug is humanized and quite good than rituximab. And also talked that it`s a stage 1 trial for 7 months..
By the way, are you improving whit rituximab
Thanks
Bruno

PeninaD · Answer

Rituximab is not in Stage III trials because it will be out of patent very soon, and the same drug company has one of the other humanized "MABs" in the pipeline.  To continue pouring funds into testing it up to FDA approval would probably lose money, because the generics would be used, therefore, they would LOSE big.  As they have to answer to their stockholders, this medication will never go on to FDA approval, unless someone pours their own funding into it.

kwarendorf · Answer

I am not part of this specific trial but I do get rituximab, another monoclonal antibody.  I also have SPMS. MS is an off label use for rituximab, so I suppose iot could be in trial mode. I think the real reason it remains off label is that no one wants to pay for the trials to get MS on the label :-)

My B & T lymphocytes are monitored to gauge the effectiveness of rituximab. I had my first infusions late last year and my first monitoring blood work last week. So far so good!

Kyle

Ddelacova · Answer

Thanks a lot

immisceo · Answer

Hi Bruno.

I have not been on this trial, but I am taking a humanised monoclonal antibody for MS (similar to what MEDT-551 is). Perhaps it's this trial? http://clinicaltrials.gov/show/NCT01585766 

MEDI-551 was mentioned on this forum before and I wrote a lot (too much!) at the time, so I will leave the link with you. http://www.medhelp.org/posts/Multiple-Sclerosis/MEDI-551/show/1961315

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