Unfortunately DMDs don't do anything for relief of symptoms. That's a problem caused by neurological damage. The accrual of damage is slowed down by the DMDs, so you'll get more of a chance to heal the damage than you had before.
I would talk to your doctor about fatigue. I have the same problem - I get tired during the day, and sometimes I could just nod off at work! I take acetyl-L-carnitine, which is a nutritional supplement (OTC.) It seems to help. If I need more help, most likely I'll go with amantadine or something similar.
I find that not getting too tired helps with the headaches. I take naps or sleep when I'm tired and while I know it's not good, I drink caffinated beverages to help with the headaches. Your nuero can help with drugs for fatigue if you so choose. Managing MS gets easier! Hang in there!
I have had bad headaches for most of my MS, 46 years. I can remember them since age five. I have gone on a variety of medications. Mine turn into migraines and I vomit for up to 18 hours. I have permanent, vertigo and double vision since early childhood, and now have ON, which contributes to them. Mine can be so bad I hope I am having an aneurysm and it will be over once ace and for all. I have been to headache Specialists who could not help. I tried Topamax which has helped others but did not work for me. I take a variety of anti seizure drugs to lessen them. I also take Immitrex, or Frovia, on Malatax on a regular basis which is not recommended but I have little choice.
Alex