MULTIPLE SCLEROSIS RISK AFTER OPTIC NEURITIS

[sllowe]

     Check this out - results from follow up study/trial:
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Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up

Optic Neuritis Study Group.
Collaborators (28)

Brodsky M, Nazarian S, Orengo-Nania S, Hutton GJ, Buckley EG, Massey EW, Bhatti MT, Greer M, Goodwin J, Wall M, Savino PJ, Leist T, Miller NR, Irani D, Trobe JD, Cornblath W, Kaufman DI, Eggenberger E, Kupersmith MJ, Shults WT, McAllister L, Hamilton S, Beck RW, Dontchev M, Gal RL, Kollman C, Keltner JL, Smith CH.

OBJECTIVE: To assess the risk of developing multiple sclerosis (MS) after optic neuritis and the factors predictive of high and low risk. DESIGN: Subjects in the Optic Neuritis Treatment Trial, who were enrolled between July 1, 1988, and June 30, 1991, were followed up prospectively for 15 years, with the final examination in 2006. SETTING: Neurologic and ophthalmologic examinations at 13 clinical sites. PARTICIPANTS: Three hundred eighty-nine subjects with acute optic neuritis. MAIN OUTCOME MEASURES: Development of MS and neurologic disability assessment. RESULTS: The cumulative probability of developing MS by 15 years after onset of optic neuritis was 50% (95% confidence interval, 44%-56%) and strongly related to presence of lesions on a baseline non-contrast-enhanced magnetic resonance imaging (MRI) of the brain. Twenty-five percent of patients with no lesions on baseline brain MRI developed MS during follow-up compared with 72% of patients with 1 or more lesions. After 10 years, the risk of developing MS was very low for patients without baseline lesions but remained substantial for those with lesions. Among patients without lesions on MRI, baseline factors associated with a substantially lower risk for MS included male sex, optic disc swelling, and certain atypical features of optic neuritis. CONCLUSIONS: The presence of brain MRI abnormalities at the time of an optic neuritis attack is a strong predictor of the 15-year risk of MS. In the absence of MRI-detected lesions, male sex, optic disc swelling, and atypical clinical features of optic neuritis are associated with a low likelihood of developing MS. This natural history information is important when considering prophylactic treatment for MS at the time of a first acute onset of optic neuritis.

I will post the link to our favorites links HP!

-Shell

[sllowe]

bump

[sllowe]

bump

[Marmite100]

What a brilliant thread, thank you!

It's puts things into perspective, very much appreciated :-)

I thought I had a contact lens infection when ON first occurred for me and went to minor injures for some antibiotics (although my eye wasn't red).  I would completely agree about the mascara feeling.

Sandie do you have your appointment soon?

[sllowe]

Hi Sandie,

Welcome to the forum.  Though you found us throught this ON discussion, I'm going to ask you to copy and paste your post here to a new one all on it's own.  One you copy it, just click on "post a question" and paste it there.

That way we can welcome you properly and respond to your concerns.  

So glad you are going to a the neuro.

Thanks for joining us!

[sandie490]

Hey sllowe, and everyone else!

I have been experiencing, twitching, weakness, a little burning, and pain in the eyball when moved certain ways.  Once in a while it feels like I have the masqara, or sand also.  
In the morning, alot of times, it actually feels like the lid is drooping a little, and stays that way most of the morning.  Then, throughout the day, my eye will twitch, and when I close my eye and try to open it,the lid gets tremors, and little shakes and it is difficult to open.
I have had that symptom for a couple of months, the eye pain started this week, but it doesn't appear to be progressing yet.  I have had bad vertigo on and off also. My eyeball feels sore all the time. No vision distortion except, I just bought new glassed 6 months ago, but they don't feel strong enough, having trouble seeing, keep needing to refocus all the time.
Does this sound familiar to anyone?  I am undxed.  My sis was just dx, just from ON, vertigo, one brain lesion,one positive lp band.
I have an app for my neuro I think Aug.  Any thoughts about these eye symptoms?  
Anyway, there you go, Isn't this annoying!   Sandie

[Becky559]

Thank you for all the information, and the stories that it led to. I will know more this Monday. I hope this isnt a long time in diagnosising me,(whether it is or isnt) as I see it has been for so many people on this site. Iam sorry the anyone facing this or dealing with its effects.
Thanks,
Becky