MULTIPLE SCLEROSIS RISK AFTER OPTIC NEURITIS

[sllowe]

     Check this out - results from follow up study/trial:
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Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up

Optic Neuritis Study Group.
Collaborators (28)

Brodsky M, Nazarian S, Orengo-Nania S, Hutton GJ, Buckley EG, Massey EW, Bhatti MT, Greer M, Goodwin J, Wall M, Savino PJ, Leist T, Miller NR, Irani D, Trobe JD, Cornblath W, Kaufman DI, Eggenberger E, Kupersmith MJ, Shults WT, McAllister L, Hamilton S, Beck RW, Dontchev M, Gal RL, Kollman C, Keltner JL, Smith CH.

OBJECTIVE: To assess the risk of developing multiple sclerosis (MS) after optic neuritis and the factors predictive of high and low risk. DESIGN: Subjects in the Optic Neuritis Treatment Trial, who were enrolled between July 1, 1988, and June 30, 1991, were followed up prospectively for 15 years, with the final examination in 2006. SETTING: Neurologic and ophthalmologic examinations at 13 clinical sites. PARTICIPANTS: Three hundred eighty-nine subjects with acute optic neuritis. MAIN OUTCOME MEASURES: Development of MS and neurologic disability assessment. RESULTS: The cumulative probability of developing MS by 15 years after onset of optic neuritis was 50% (95% confidence interval, 44%-56%) and strongly related to presence of lesions on a baseline non-contrast-enhanced magnetic resonance imaging (MRI) of the brain. Twenty-five percent of patients with no lesions on baseline brain MRI developed MS during follow-up compared with 72% of patients with 1 or more lesions. After 10 years, the risk of developing MS was very low for patients without baseline lesions but remained substantial for those with lesions. Among patients without lesions on MRI, baseline factors associated with a substantially lower risk for MS included male sex, optic disc swelling, and certain atypical features of optic neuritis. CONCLUSIONS: The presence of brain MRI abnormalities at the time of an optic neuritis attack is a strong predictor of the 15-year risk of MS. In the absence of MRI-detected lesions, male sex, optic disc swelling, and atypical clinical features of optic neuritis are associated with a low likelihood of developing MS. This natural history information is important when considering prophylactic treatment for MS at the time of a first acute onset of optic neuritis.

I will post the link to our favorites links HP!

-Shell

[michelleric]

Thank you for posting this. I have had 2 bouts of ON, vision still recovering in one eye. Just wanted to thank you for this information,
Michelle

[Karen99]

After nearly two years of MS sensory-type symptoms, I developed optic neuritis.  It caused blurry vision in one eye and a good deal of pain upon any eye movement.  I went to several opthamologists and optomotrist who found nothing wrong.  One bright  opthamalogist LISTENED to me despite nearly normal vision tests.  He told me that even though I was seeing well, I knew my vision better than anyone else, thus he believed that there was something amiss.  He suggested I get an MRI.  

I got home and researched the topic and I didn't like the answer and figured, oh well, if I have MS I'll know soon enough.  The thought of having MS scared me so I ignored it until I could ignore it no more when double vision set in along with numbness and profound fatigue.  This was about a year later from the optic neuritis.

It's great when doctors listen to us even when we ignore their suggestions.  His suggestion did prepare me for the diagnosis of MS.  I knew something was wrong in my central nervous system.  I could feel my brain on fire.  (that sensation has stopped.)  H

Has anyone else had the sensation of brain heat when in an exacerbation or relapse?

[Eyesnlegs]

What a great bump

Very informative, can someone please tell the world about ON - when I had it so very badly in 1989 I was not even referred to a neurologist let alone let near to an MRI.

Do I sound bitter - well that's because I am!

Bless all you wonderful folks for the info you give here
Pat
x

[sllowe]

BUMP

[Deb61]

Maybe the MRI I just had a few weeks ago will show if they are old or new lesions on the optic nerve.  I haven't heard about the results yet.  The MRI before last didn't show anything--but that area of brain was not focused on.  

[LATW]

Have you had an MRI? That is what helped get mine dx'd last year.  This second time with ON I had optic palar but still had another  MRI.

LA