New DMD Oral Therapy Study: CONFIRM Trial Phase 3

[sllowe]

Keeping up on topic wants (studies)...Oral versus injection is down right exciting!

http://www.mscare.org/cmsc/News/CMSC-INForMS-Biogen-Idec-Announces-Positive-Top-Line-Results-from-2nd-PIII-Trial-of-Oral-BG-12.

"BG-12 met the CONFIRM study's primary endpoint by significantly reducing annualized relapse rate (ARR) by 44 percent for BID (p< 0.0001) and by 51 percent for TID (p< 0.0001) versus placebo at two years. The CONFIRM study's reference comparator, glatiramer acetate (GA; 20 mg subcutaneous daily injection), reduced the ARR by 29 percent (p< 0.02) compared with placebo at two years..."

Like Gilenya, the future will tell what impact the new oral DMDs (and BG-12 above) will have on MS, and the quality of the lives for those who are on them - but for now, I'm definitely excited.

-Shell

[sllowe]

Max-C - That's how I read it. It's not to say the traditionals are not still good - they have the longest track record, and no new med can take that away - but this progress in meds makes me so hopeful for the future impact on MS - yay!

fwiw - There is another study update on the MS Consortium with a late stage trial that is showing better results too as compared to Rebif, but that's not an oral.

Aftermarket will tell the tale on these future meds for sure - and also how tolerable they are, side affects, etc....  
-shell

[maxthecat9196]

Am I understanding that correctly?  Does the study indicate greater success with the new oral drug than with copaxone?

[Lulu54]

I took the period out of the link and I can see it now!  go figure................  :-)

[sllowe]

fyi - Including the period at the end of the link...

[sllowe]

Lu - may be your browser, because I just checked it again. Copy it in it's entirety, and paste directly into your browser........

[Zacksmomi]

My Dr is putting me on the BG-12 I think as soon as it comes out.  She says it is really a promising choice for those like me who are not having luck with injections or infusions.

Actually she had a few words to say about the FDA holding back on it as it is a MUCH safer drug than fingolimoid of gilenya.

Oh the future is looking brighter every year for us :)
D

[LisaJF]

I'm excited for you all too if you all decide should go that route!  Sounds promising doesn't it?

However, I wonder if people would want to switch to oral after doing years of injections or receiving infusions and feel they may be taking a risk by going off what was working for them to begin with?

[Lulu54]

Shell, those links are not working for me.  We may need to find another article to link.  From what I read, the results of this trial made many people at ECTRIMS go "WOW!!"  The results were far superior than they had hoped for.

[sllowe]

             http://www.mscare.org/cmsc/News/CMSC-INForMS-Biogen-Idec-Announces-Positive-Top-Line-Results-from-2nd-PIII-Trial-of-Oral-BG-12.

If this link is not hot - copy and paste into browser :(