I am a pianist/music teacher and about 18months ago I noticed that when I practised for a long time I would get contractures in my left hand. At the same time I noticed that when I went for walks ( I am active in outdoor pursuits) I always seemed to be stiff afterwards. My piano playing ability seemed to be deteriorating..which I put down to too much work! However I suddenly was finding it difficult to walk any distance at all as my legs would get stiff. My GP referred me to a neurologist who noted that I had asymetric reflexes, with pathological briskness and told me I had a spastic myelopathy. I have had few other symptoms only a light blurring of vision in my right eye, some bladder irregularities..sometimes frequent, sometomes spastic, and a dodgy balance. Also my piano playing is nothing like as accurate as it was. Now I am expereincing extreme weakness, especially in my arms..like I have problems draining saucepans or reading heavy books. AN MRI scan showed markedly enlarged cerebellar sulci, and a dilated fourth ventricle.(I.E.Cerebellar atrophy.) Ohther than that all tests..EP's , CSF, Extensive blood tests for lupus and B12 deficiency have all been negative. My consultant says this rules out MS..which was his initial diagnosis, Lupus and B12 deficiency. AS I do not have a full range of cerebellar symptoms (only the slight balance problems and spasticity) he is reluctant to say it is cerebellar atrophy, until i have repeat scan in 18months time. In the meantime he is attributing my symptoms to a post viral syndrome. I am now noticing that my scalp and face feel stiff, and I occassiaonally talk as though I have been to a dentist. Also thigs over the last few months seem to be getting marginally worsr..whereas I only had sever spasticity when I was ill or stressed it seems to be more regular...the days when i felt almost normal have gone. I have tried to keep myself fit by swimming 3 times a week, but it exhausts me now, and I notice that my muscles are beginning to bulk. Do you feel that the cerebellar atrophy is significant? I guess i should also tell you I am a carrier of Fragile X Syndrome.