PSA levels

[zannablue]

a psa level of over 300 in a 45 y/o male, is that always indicative of prostatic ca
what other problems might cause a level this high

[chrile]

My father in law was diagnosed with extensive metastasis prostate cancer..He had his testicles removed and put on hormone therapy.  This past month his PSA results showed a spike from 5.0 to 260 and in less than a week a retest showed even higher numbers, it spiked to 300 in less than ten days...

What is happening here? why this sharp abrupt spike?

[Rich99]

Thats the most obvious.     Even enlarged prostates or infection are not that hight.     At that level,   a biopsy should be done as soon as possible.