This is a really interesting question! Is your pleurisy chronic? It's often caused by infection (bacterial, viral or fungal) and in those cases it gets better. But if caused by say something like an autoimmune disorder, you may have to deal with this long term. https://www.mayoclinic.org/diseases-conditions/pleurisy/symptoms-causes/syc-20351863 Usually they treat it by addressing and controlling the underlying condition. So, I'd focus on that with your doctor too. Most people recover from pleurisy. High altitudes are harder on the lungs. So, yes, if you have a chronic lung issue, the higher altitude might make it harder. Cold air is also harder on respiratory conditions. Wyoming is beautiful though.