My 17-year old son has complained of feeling tired, and has trouble concentrating. He is an excellent student (high achiever) and musician, and his symptoms can keep him from being able to get his work done. He always has been more often cold than warm. I have hypothyroidism, and my mother had hyperthyroidism and had her thyroid destroyed by radioactive iodine. My dad had hypothyroidism. Son's blood test came back with no thyroid trouble, but is there a more sensitive test or perhaps you have a suggestion. He has had a physical since these symptoms, and is being treated with Prozac, which has been somewhat helpful, especially with irritability. He is not overweight but has poor muscle tone.