I was on Depo Provera for BC for 8 years with no side effects but headaches, which were manageable. Also had no periods, which was great! However, I became ill when I stopped having the injections at age 45. I experienced fatigue, joint pain and swelling, and depression. I was tested for everything from Lyme disease and Lupus, to thyroid conditons - all negative. My Dr. finally gave up and diagnosed me with Chronic Fatigue syndrome. My OBGYN ran a bone scan and diagnosed me with osteopenia, and declared me menopausal, since my periods have also not resumed. Now nearly 4 years later I am still miserable - fatigue, depression, headaches, cold all the time, and I suspect hypothyroidism. I also have learned that Depo causes bone density loss so maybe I am not menopausal. I don't mean to sound whiny and pitiful, but I can hardly remember the energetic, optimistic person that I used to be. I am sick and tired of being sick and tired! I have been searching the net and find lots of women with lots of side effects from taking Depo Provera, but I am trying to find other women who have experienced problems after QUITTING the injections.