You're right, Annie, she did say she's on 25 mcg Cytomel twice a day (I believe it's 25, not 0.25). If nothing else, starting someone initially on a T3-only meds is very unusual. However, it seems that her doctor ordered a combo T3/T4, but the clinic messed up and gave her Cytomel, telling her it was a T3/T4 combo, which we all know it is not.
I agree that she should be on both meds or T4 only. Her FT4 is so low that it's impossible to know at this point if she needs T3 meds or not. However, a little T3 at this point will help her to feel better if taken with T4 meds until the T4 has time to build to a reasonable level. I also agree with Annie that she probably was always undertreated, and that's why she thought the Synthroid, etc. didn't work. A higher dose of Synthroid (perhaps starting out low and building, depending on other health issues, etc.) should get both FT3 and FT4 higher in their ranges (if there's no conversion issue).
T3-only is the treatment for RT3 dominance, or Wilson's syndrome. The idea here is to shut down conversion completely, which also shuts down the production of RT3. This allows the RT3 to be purged from the body. It's a "temporary" treatment until the RT3/FT3 balance is restored.
Yes, there's always some merit in keeping things as close to "natural" as possible, including maintaining the deiodination process. However, with Wilson's that process has been corrupted...too much RT3 is being converted compared to FT3. Wilson's syndrome is actually not a thyroid condition (although it aften accompanies thyroid conditions); it's a failure to metabolize T4.
Anyway, after all that discussion of Wilson's, her FT3/RT3 balance looks "good", so I don't think that's a factor.
I agree that T3-only meds is not the way to go right now. That FT4 needs to come up, and Cytomel isn't going to do anything for it.
Yes Magpieannie, that is exactly what I meant. I have been on just T4 for many years. My last T4 med only I was on was 200. mcgs Eltroxin for several years and I felt like it was doing nothing at all, so about 8months ago I got my Dr, to switch me to Naturthroid 125. mcg apparently the uptake is different so the doseage was lowered and again, I felt like nothing was working. My body just started shutting down and I started putting on weight again, freezing, muscle cramping, hair & nails brittle, dry skin, insomnia . Now I have these lab results. Maybe I had a bad batch of meds of something. Oh I wish I had instructed the clinic properly and got a T4 and T3 combo. Luckily this is a short month, so its less than a week until I get into see my Dr who is on holidays. Our city is hosting the 2010 Winter Olympics right now so alot of locals that could afford to, have left.... I really appreciate everyone's input. Thank you so much.
I agree with you magpieannie !
She might not need T3 at all !
I think Conitchewa was saying that she's on .25 mcg of t3 (Cytomel) twice a day now and no t4 (Synthroid). ( Is that correct, Coni.?)
I would think that she she should be on both meds, Synthroid with the addition of Cytomel twice per day. Looking at her labs, both levels are extremly low and that TSH is way to high. NO wonder she hurts all over! Maybe she didn't do well before on Synthroid alone due to being under dosed? Maybe Synthroid alone at a higher dose would do the trick and get that t3 and t4 higher in their ranges? If not, I would add the cytomel to it, but I would not take the cytomel t3 alone without t4. (my daughters doctor thought about giving her a try with this "Wilson's Temp. Syndrome." approach, (time released t3) and I said no.) I think the body is suppose to utilize that deodinization process, so we shouldn't side step it- it's there for a reason! However, if we need to assist the body with the conversion process, then by all means, adding a little t3 to the t4 can help get that t3 level up if the body cannot do it with t4 alone. Of course, she will need to discuss these options with her doctor!
What is everyone elses thoughts on this?
You are less than two weeks away from seeing your doctor.
You are very hypothryoid. No wonder you're feeling so bad.
The dose of 25 mcg of T4 only med / day is ok to start with and you need to be taking it straight away. Your doctor can adjust meds / prescribe a different combo when she sees you.
Hang in there, it can take some time to get to feeling better but at least you will be on the way now.
The high TSH and low Free's say that you are extremely Hypothyroid
You are not supposed to be on T3 medicine only
The T4 medicine didn't work for you because you were undertreated
This is a process that can take years to reach the exact dose you need
And you will not feel well untill you reach that dose exactly
That means 50mcg/week more or less and you remain symptomatic
You might also want to ask for anti TGab and anti TPOab to see if the cause is hashimoto
feel well,