Has anyone changed their thyroid medication and noticed a drastic difference ? I was taking Levoxyl for hypo-thyroidism and it was automatically changed to the generic form, L-Thyroxine. After taking the Thyroxine I noticed a terrible burning in the throat and indigestion which I never had with the Levoxyl. So I am requesting to be changed back to the Levoxyl. I think some of these medications have different ingredients. I never had this happen with the Levoxyl. I hope this helps anyone who has been put on the generic form of medication. Someone asked earlier if this will ever go away. No, once you develop thyroid disease it is for life. So always take your medication, you need it to be healthy. Thanks.