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Interesting study result:
Several forum members discussed if Hashimoto's thyroiditis can increase the risk of thyroid cancer.
I've found the article abstract regarding the study of this subject.
"Volume 150, Issue 1, Pages 49-52 (November 2008)
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Is Hashimoto's Thyroiditis a Risk Factor for Papillary Thyroid Cancer?
Top of Form
Daniel Repplinger, B.S., Anna Bargren, B.S., Yi-Wei Zhang, B.S., Joel T. Adler, B.A., Megan Haymart, M.D., Herbert Chen, M.D., F.A.C.S.
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Received 10 August 2007 published online 29 October 2007.
Background
Hashimoto's thyroiditis (HT) is the most common cause of hypothyroidism and is characterized by gradual autoimmune mediated thyroid failure with occasional goiter development. HT is seven times more likely to occur in women than in men. Papillary thyroid cancer (PTC), the most prevalent form of cancer in the thyroid, is 2.5 times more likely to develop in women than men. Given the relatively high prevalence of these diseases and the increased occurrence in women, we analyzed data from our institution to determine if there is a correlation between Hashimoto's thyroiditis and PTC in women.
Methods
From May 1994 to January 2007, 1198 patients underwent thyroid surgery at our institution. Of these, 217 patients were diagnosed with HT (196 women, 21 men). The data from these patients were statistically analyzed using SPSS.
Results
PTC occurred in 63 of 217 (29%) HT patients and 230 of 981 (23%) patients without HT (P = 0.051). Of these groups, 41 (65%) and 158 (69%) patients, respectively, had tumor sizes ≥1.0 cm; 56/196 women (29%) with HT had coexistent PTC compared with 160/730 women (22%) without HT (P = 0.03). Among women with any type of thyroid malignancy, 56/59 cases (95%) with HT had PTC compared with 159/196 cases (81%) in women without HT (P = 0.006). Additionally, female HT patients WITH GOITERS had a significantly lower rate of PTC (9% versus 36%, P < 0.001) compared with women without goiters. These differences were not observed in men with HT.
Conclusions
These data demonstrate that HT is associated with an increased risk of developing PTC. Female patients with HT undergoing thyroidectomy are 30% more likely to have PTC. Thus, more aggressive surveillance for PTC may be indicated in patients with HT, especially in women.
I've found the article abstract regarding the study of this subject.
"Volume 150, Issue 1, Pages 49-52 (November 2008)
Bottom of Form
Is Hashimoto's Thyroiditis a Risk Factor for Papillary Thyroid Cancer?
Top of Form
Daniel Repplinger, B.S., Anna Bargren, B.S., Yi-Wei Zhang, B.S., Joel T. Adler, B.A., Megan Haymart, M.D., Herbert Chen, M.D., F.A.C.S.
Bottom of Form
Received 10 August 2007 published online 29 October 2007.
Background
Hashimoto's thyroiditis (HT) is the most common cause of hypothyroidism and is characterized by gradual autoimmune mediated thyroid failure with occasional goiter development. HT is seven times more likely to occur in women than in men. Papillary thyroid cancer (PTC), the most prevalent form of cancer in the thyroid, is 2.5 times more likely to develop in women than men. Given the relatively high prevalence of these diseases and the increased occurrence in women, we analyzed data from our institution to determine if there is a correlation between Hashimoto's thyroiditis and PTC in women.
Methods
From May 1994 to January 2007, 1198 patients underwent thyroid surgery at our institution. Of these, 217 patients were diagnosed with HT (196 women, 21 men). The data from these patients were statistically analyzed using SPSS.
Results
PTC occurred in 63 of 217 (29%) HT patients and 230 of 981 (23%) patients without HT (P = 0.051). Of these groups, 41 (65%) and 158 (69%) patients, respectively, had tumor sizes ≥1.0 cm; 56/196 women (29%) with HT had coexistent PTC compared with 160/730 women (22%) without HT (P = 0.03). Among women with any type of thyroid malignancy, 56/59 cases (95%) with HT had PTC compared with 159/196 cases (81%) in women without HT (P = 0.006). Additionally, female HT patients WITH GOITERS had a significantly lower rate of PTC (9% versus 36%, P < 0.001) compared with women without goiters. These differences were not observed in men with HT.
Conclusions
These data demonstrate that HT is associated with an increased risk of developing PTC. Female patients with HT undergoing thyroidectomy are 30% more likely to have PTC. Thus, more aggressive surveillance for PTC may be indicated in patients with HT, especially in women.
Ha ha that was funny......and with the knowledgement to Medhelp community patients...
Wow! I think later we would write a project called "The modern approach to the thyroid disorders management" or sitmilar to this.
Got an answer from the author of the paper about Thyroid antibodies, he said it was difficult to say and: "Our patients in the study had HT by pathology evaluation. I am not sure how many actually had position antibodies".
So the ones that have Hashi and no goiter should check all nodules that have more then 1 cm...............
So the ones that have Hashi and no goiter should check all nodules that have more then 1 cm...............
Good info! Good to know I will pass this on to two females that are in my family both have Hashi.. one with a Goiter. Just the opposite of what one would think concerning risks. Thanks!
Hashi patients have TPO antibodies and some have also anti-Tg , Dr. Lupo said somewhere in the forum that there are people with Hashi and with no positive antibodies...., so Ultrasound would confirm this...(http://www.medhelp.org/forums/Thyroid/messages/1119.html)
I would really like to know if there is a relashionship between this anti-Tg and PTC in patients with Hashi, just a thought. I wrote to the author of the paper, hope he answers me.....
I would really like to know if there is a relashionship between this anti-Tg and PTC in patients with Hashi, just a thought. I wrote to the author of the paper, hope he answers me.....
This article does not mention level or type of antibodies ; about 5% of Hashimoto's patients do not have elevated antibodies.
I''ve read the article, and one thing that they didn't say is the association of thyroid antibodies in this patients and the presence of Papillary Thyroid Cancer? If all the patients with HT/PTC had both antibodies (TPO and anti-Tg)? or is not relevant having just TPO antibodies? 898 do you have any idea about this?
Interesting. CFS patients (possibly fibro as well)... also have a higher risk of getting thyroid cancer. I guess it is because we do have a low thyroid, but often the lab results will not detect this.
"Thyroid malignancy in ME/CFS patients greatly exceeds the normal incidence
of thyroid malignancy in any known subgroup. The thyroid malignancy
incidence in the ME/CFS group may exceed 6,000 / 100,000. As part of their
investigation, Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)
patients should be examined by thyroid ultrasound for evidence of thyroid
pathology and malignancy."
link to entire document:
http://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind0805D&L=co-cure&P=R3591
"Thyroid malignancy in ME/CFS patients greatly exceeds the normal incidence
of thyroid malignancy in any known subgroup. The thyroid malignancy
incidence in the ME/CFS group may exceed 6,000 / 100,000. As part of their
investigation, Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)
patients should be examined by thyroid ultrasound for evidence of thyroid
pathology and malignancy."
link to entire document:
http://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind0805D&L=co-cure&P=R3591
Interesting.
Of the 4 in my family with cancer, three also have Hashi's (I'm the only one without it)
the two with precancer also have Hashi's.
Interesting it's not just my whacked out family that has toe correlation.
Of the 4 in my family with cancer, three also have Hashi's (I'm the only one without it)
the two with precancer also have Hashi's.
Interesting it's not just my whacked out family that has toe correlation.
Yes but I have a multinodular thyroid and two of them have 9 mm and 8mm.....No goiter, no medication.....In November I'm going to do another ultrasound.....
I believe it is true if nodule found is larger then 1 cm; for smaller nodules that may not be the case
It's good to know that we are in trouble..Ha ha As I can understand at the end of the abstract they say that women with Hashi and no goiter are in more risk to have PTC?? is it right? (that's my case).
Brief summary:
The Hashimoto's patients of both genders are MORE likely to develp cancerous nodule then these who do not have Hashimoto's disease;
The female Hasimoto's patients WITH goiter are LESS likely to develop cancerous nodule then these without goiter,
For male patients the presence of goiter is not significant factor.
The Hashimoto's patients of both genders are MORE likely to develp cancerous nodule then these who do not have Hashimoto's disease;
The female Hasimoto's patients WITH goiter are LESS likely to develop cancerous nodule then these without goiter,
For male patients the presence of goiter is not significant factor.
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