That sounds like a little high of a dosage to start with....is your doc an endo? If you have a hard time with palps, call the dr and ask him to start you at 75 instead. With synthroid you have to work your way up slowly if you have never been on meds. I remember when i had first started it and i had palps and racey feeling for a little while. Try it and see....just don't freak out if you start feeling racey....it usually goes away within a week unless your dosage is too high.
Not if your in tip top shape. Most doctors would start you off .75 for three days and then work your way up. If your concerned make sure you tell them. It really doesn't have many side effects. Just make sure they know what your taking with it since some meds will have to be taken at a later time:)