Slightly hyperthyroid and 3 miscarriages

[KWS74]

I am slightly hyperthyroid (TSH = .2-.4 range for the last 2 years) and have had 3 miscarriages in the last 10 months (from natural conception).  All of my fertility-related tests have come back normal (including genetic screening, uterine abnormalities, clotting disorders, chromosomal tissue testing etc).  We recently sought out a fertility specialist for consultation and he suggested that antibodies affecting thryoid could also indicate other antibodies affecting pregnancy and suggested we see an endocrinologist.  I haven't been able to find any literature on this and I am on a 3 month waiting list to see a thyroid specialist.  My T3 and T4 levels are normal.  Any thoughts on the antibody hypothesis?  Could there be any correlation, given that I am only slightly hyperthyroid?

Thank you in advance!

[Red_Star]

Edit: Sorry, i've somehow put up the wrong title for the above study. The study should be titled: Female infertility related to thyroid autoimmunity: the ovarian follicle hypothesis.

Thyroid dysfunction and autoimmunity in infertile women is for study - PMID: 12490077.  

[Red_Star]

The latest study on pubmed; August 2011...

PMID: 21241400

"Thyroid dysfunction and autoimmunity in infertile women.

The aim of this study was to verify whether anti-thyroid antibodies are present in the follicular milieu of euthyroid infertile women with thyroid autoimmunity undergoing in vitro fertilization (IVF) and whether IVF outcome is different in affected women with respect to negative controls. A secondary endpoint was to check whether there are changes in thyroid hormone levels during the IVF cycle.

METHOD OF STUDY:
Anti-thyroglobulin and anti-thyroperoxidase levels were measured in both follicular fluid and serum on the day of oocyte retrieval in women with thyroid autoimmunity. Serum TSH, FT3, and FT4 levels were measured in all patients before treatment initiation, on the day of oocyte retrieval and of pregnancy test. IVF outcome parameters were recorded in all women.

RESULTS:
Oocyte fertilization, grade A embryos, and pregnancy rates were lower in women with thyroid autoimmunity than in negative controls, while early miscarriage rate was higher. Anti-thyroid antibodies were measurable in follicular fluid in all affected women and were strongly correlated with serum levels. No significant changes in thyroid hormone levels were recorded in any women.

CONCLUSION:
The presence of anti-thyroid antibodies in ovarian follicles, as demonstrated for the first time in this study, may play a critical role in female infertility related to thyroid autoimmunity."