I was diagnosed with Hashimotos due to high TPO antibodies. I went years not being treated because my TSH was always in the normal range. Last year I developed severe muscle twitching and would have very sore cramped calve muscles when I awoke. I also had water retention, messed up periods fatigue, weight gain etc. I was referred to an endo who said she was sure I was suffering from subclinical hypothyroidism- so that even though my TSH was normal, my free t4 was right at the low end of normal and she felt I should be treated. She gave me levothyroxine and started me at .75mg. Within 3 days I felt like I was on diet pills, by the end of a week I was having severe adrenaline rushes at night, right when I would drift off to sleep, I would be awaken by an adrenalin rush and this went on all night, I also had sweating and had to urniate frequently. The endo said she thought that the meds had maybe awakend an underlying anxiety problem. I am thinking it awakend an underlying adrenal problem! I stopped the meds and it retried 3 weeks later at .25mg. The same thing happened only this time it took a little longer before the adrenaline rushes started. It has been a year since I stopped taking the meds and I haven't had that happen since. I am still suffering from extreme hypo symptoms and last week my TSH came back at 11. I am not sure what to do from here. Any ideas? Any one ever heard of thyroid meds causing adrenal problems, or "awakening" an anxiety problem?