When I turned 51 they noted elevated TSH levels and I was referred to the Endo and am now taking 100 mcg synthroid. My sister has been diagnosed with hashimoto's disease....so I guess it runs in the family. I am not familiar with 1131 ablation so I will have to look that up.
Most likely you will have biopsy for the cold nodules.
What was the original cause for hypothyroidism?
The nodule on the isthmus is less then 1 cm, so the doctor may decide if to wait and watch.
For the hot nodules the I131 ablation is very effective on patients over 40.