Is TSH the only test you've ever had done? What about Free T4 and Free T3? Those are the actual thyroid hormones and give a better picture than TSH alone.
TSH of 4.10 is still within the reference range, but for most of us, it would be considered hypo when we're on medication.
Could you please tell me what medication you're actually taking?
Thyroid hormones are mostly synthesized by the liver; I don't know of any damage that would be done to the kidneys, however, everyone is different so I can't know for sure because you didn't tell me what medication you're taking.
It's extremely likely that you're very hypo but again, that's impossible to say without test results for Free T4 and Free T3. Also, you should get tested for Hashimoto's if you haven't been. If you have been, please let me know if you have it.
If you believe you have kidney or other organ damage, you really need to see your doctor. If you have other questions related to thyroid, I can probably help you, but I'll need further information.
What you took 3 yrs ago will have worn off a long time ago and there would be no effect on what's happening now.
I'm not sure what you want to cure. Is it the depression or the thyroid condition?
Do you know if you have Hashimoto's, which is an autoimmune condition that gradually destroys the thyroid? If that's causing your hypothyroidism, there is no cure. You will have to be on medication for life. The goal will be to optimize your dosage so you feel the best you can feel.
If you're taking thyroid medication, please tell us what medication you're taking. T4 medications, such as Levothyroxine, Synthroid, etc are measured in mcg, whereas desiccated medications that are T4/T3 combos, such as Armour, Naturthroid, etc are prescribed in mg.
Are you still taking the same 50 mg/mcg that you were taking in 2015?
Can you please post your current thyroid hormone lab results so we can see what your status is? Be sure to include the reference ranges since those vary from lab to lab and have to come from your own report(s).
Depression is a very common symptom of hypothyroidism. Getting your thyroid hormone levels into an optimal range should help considerably to alleviate or lessen depression. Therapy is also a good route to take if thyroid medication isn't enough to alleviate it.