Aa
VITAMIN-E AND RESVERATROL REPLICATE HCV
hello to all and hope my post finds u all in better health and spirit .
I am 38 years old and got infected with hcv 3 years ago , i went through the regular tx and relapsed within 2 weeks of completeing ( geno 1a ), anyway i now await the new treatments that are suppose to come out in the next year or two and will decide then as to what needs to be done .
(i did post once before about the same topic .. but got no feedback except from a genteleman named bill - thanks bill .)
the only reason i post is to share my story and make others aware of the harm of "vit e and resveratrol" .
well here we go again ....
last year in december all m liver enzimes were normal ie: ast 30 alt 30 , but i was still hcv + with a viral load of 9000 .
in feburary this year i started feeling a bit weak and decided that juiceing may be a good idea , i started juicing with strawberries , black and green grapes , carrots , pomegranade , and some lemon .
i was also having my regular supplements that include - milk thistle , vit b / c / and a multi vit withought iron .
after a few days of juicing and feeeling mentally good i added vitamin e to my supplement list - reading that it was a great anti-oxidant .
well i was due for a lft in march and my report came back with ast= 62 and alt 161 . i continued with the juice and the vit e not realinzing that they could be the culprit .
after 2 weeks of checking again my ast was 106 and alt 320 ... and thereafter another week they went up to ast- 116 and alt = 400 , i paniced and though what is it... what is it ..... here im trying to do everything thats good for my body and liver but whats going on .... then thanx to the mystic law of the universe i tumbeled upon this study .
Quote from the article.
"To date, only a limited number of studies have reported finding an influence of ordinary nutrients on hepatitis C virus (HCV) RNA replication. However, the effects of other nutrients on HCV RNA replication remain largely unknown.
Here, using this OR6 assay system, we comprehensively examined 46 nutrients from four nutrient groups: vitamins, amino acids, fatty acids, and salts. We found that three nutrients-beta-carotene, vitamin D(2), and linoleic acid-inhibited HCV RNA replication and that their combination caused additive and/or synergistic effects on HCV RNA replication. In addition, combined treatment with each of the three nutrients and interferon alpha or beta or fluvastatin inhibited HCV RNA replication in an additive manner, while combined treatment with cyclosporine synergistically inhibited HCV RNA replication. In contrast, we found that vitamin E enhanced HCV RNA replication and negated the effects of the three anti-HCV nutrients and cyclosporine but not those of interferon or fluvastatin. These results will provide useful information for the treatment of chronic hepatitis C patients who also take anti-HCV nutrients as an adjunctive therapy in combination with interferon. In conclusion, among the ordinary nutrients tested, beta-carotene, vitamin D(2), and linoleic acid possessed anti-HCV activity in a cell culture system, and these nutrients are therefore considered to be potential candidates for enhancing the effects of interferon therapy.".
link for the above study - http://aac.asm.org/cgi/content/short/51/6/2016
also then i did a little more reading and found this ...
AIM: To elucidate the effect of antioxidants, resveratrol (RVT) and astaxanthin (AXN), on hepatitis C virus (HCV) replication. METHODS: We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6. RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses. AXN is also a strong antioxidant. The replication of HCV RNA was assessed by the luciferase reporter assay. An additive effect of antioxidants on antiviral effects of interferon (IFN) and ribavirin (RBV) was investigated. RESULTS: This is the first report to investigate the effect of RVT and AXN on HCV replication. In contrast to other reported viruses, RVT significantly enhanced HCV RNA replication. Vitamin E also enhanced HCV RNA replication as reported previously, although AXN did not affect replication. IFN and RBV significantly reduced HCV RNA replication, but these effects were dose-dependently hampered and attenuated by the addition of RVT. AXN did not affect antiviral effects of IFN or RBV. CONCLUSION: These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis.
heres the link for the above study - http://www.myhealthfulworld.com/content/an-antioxidant-resveratrol-significantly-enhanced-replication-hepatitis-c-virus
i since have completely stopped taking the vit e and the juice . please note that grapes , peanuts , strawberries and pomegranade all contain high amounts of resvetrol .
I also stopped taking the multivitamin withough iron as it contained vit e ...
i have discussed this topic with a few friends but they dont seem to think resvetrol and vit e can do any harm !!! i wonder !!
but the same hcv community will come down ure throat if u say u had a beer or a steak .... ( i dont drink or eat red meat anymore ) saying that alcohol replicates hcv ... and iron is bad .. u shouldnt even eat spinich ....
well i would also like to add that 2 weeks of no juice and vit e .... and milk thistle 2 times a day have bought my ast from 116 to 96 , and alt from 400 to 275 .
PLEASE MY FRIENDS be carefull of what u eat and drink when suffering from hcv ... saying that " its natural " dosent mean its good for us ... we have a specific disease .... mud is natural too - would we eat it !!!
people without liver disease can eat and drink all that they want ..including mud -;) ..... but not us ,
i may be wrong and do welcome ure inputs .
also before i leave - i need to ask u all a small question .
as i said earlier - i was infected ( not diagnosed ) with hcv 3 years ago , do i need to get a live biopsy done !!! i dont drink or eat red meat and oily food , my ultra sound shows no enlargement ... but i am tired and have fatgue all the time .... yes my liver enzimes are high .. but im pretty sure that the reason behind that is the resveratrol and the vit e tablets which i have stopped taking now . .
thanking u and wishing u all well - await ure inputs regarding the bx .. and hope u all find the above studies helpfull.
pacman
I am 38 years old and got infected with hcv 3 years ago , i went through the regular tx and relapsed within 2 weeks of completeing ( geno 1a ), anyway i now await the new treatments that are suppose to come out in the next year or two and will decide then as to what needs to be done .
(i did post once before about the same topic .. but got no feedback except from a genteleman named bill - thanks bill .)
the only reason i post is to share my story and make others aware of the harm of "vit e and resveratrol" .
well here we go again ....
last year in december all m liver enzimes were normal ie: ast 30 alt 30 , but i was still hcv + with a viral load of 9000 .
in feburary this year i started feeling a bit weak and decided that juiceing may be a good idea , i started juicing with strawberries , black and green grapes , carrots , pomegranade , and some lemon .
i was also having my regular supplements that include - milk thistle , vit b / c / and a multi vit withought iron .
after a few days of juicing and feeeling mentally good i added vitamin e to my supplement list - reading that it was a great anti-oxidant .
well i was due for a lft in march and my report came back with ast= 62 and alt 161 . i continued with the juice and the vit e not realinzing that they could be the culprit .
after 2 weeks of checking again my ast was 106 and alt 320 ... and thereafter another week they went up to ast- 116 and alt = 400 , i paniced and though what is it... what is it ..... here im trying to do everything thats good for my body and liver but whats going on .... then thanx to the mystic law of the universe i tumbeled upon this study .
Quote from the article.
"To date, only a limited number of studies have reported finding an influence of ordinary nutrients on hepatitis C virus (HCV) RNA replication. However, the effects of other nutrients on HCV RNA replication remain largely unknown.
Here, using this OR6 assay system, we comprehensively examined 46 nutrients from four nutrient groups: vitamins, amino acids, fatty acids, and salts. We found that three nutrients-beta-carotene, vitamin D(2), and linoleic acid-inhibited HCV RNA replication and that their combination caused additive and/or synergistic effects on HCV RNA replication. In addition, combined treatment with each of the three nutrients and interferon alpha or beta or fluvastatin inhibited HCV RNA replication in an additive manner, while combined treatment with cyclosporine synergistically inhibited HCV RNA replication. In contrast, we found that vitamin E enhanced HCV RNA replication and negated the effects of the three anti-HCV nutrients and cyclosporine but not those of interferon or fluvastatin. These results will provide useful information for the treatment of chronic hepatitis C patients who also take anti-HCV nutrients as an adjunctive therapy in combination with interferon. In conclusion, among the ordinary nutrients tested, beta-carotene, vitamin D(2), and linoleic acid possessed anti-HCV activity in a cell culture system, and these nutrients are therefore considered to be potential candidates for enhancing the effects of interferon therapy.".
link for the above study - http://aac.asm.org/cgi/content/short/51/6/2016
also then i did a little more reading and found this ...
AIM: To elucidate the effect of antioxidants, resveratrol (RVT) and astaxanthin (AXN), on hepatitis C virus (HCV) replication. METHODS: We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6. RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses. AXN is also a strong antioxidant. The replication of HCV RNA was assessed by the luciferase reporter assay. An additive effect of antioxidants on antiviral effects of interferon (IFN) and ribavirin (RBV) was investigated. RESULTS: This is the first report to investigate the effect of RVT and AXN on HCV replication. In contrast to other reported viruses, RVT significantly enhanced HCV RNA replication. Vitamin E also enhanced HCV RNA replication as reported previously, although AXN did not affect replication. IFN and RBV significantly reduced HCV RNA replication, but these effects were dose-dependently hampered and attenuated by the addition of RVT. AXN did not affect antiviral effects of IFN or RBV. CONCLUSION: These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis.
heres the link for the above study - http://www.myhealthfulworld.com/content/an-antioxidant-resveratrol-significantly-enhanced-replication-hepatitis-c-virus
i since have completely stopped taking the vit e and the juice . please note that grapes , peanuts , strawberries and pomegranade all contain high amounts of resvetrol .
I also stopped taking the multivitamin withough iron as it contained vit e ...
i have discussed this topic with a few friends but they dont seem to think resvetrol and vit e can do any harm !!! i wonder !!
but the same hcv community will come down ure throat if u say u had a beer or a steak .... ( i dont drink or eat red meat anymore ) saying that alcohol replicates hcv ... and iron is bad .. u shouldnt even eat spinich ....
well i would also like to add that 2 weeks of no juice and vit e .... and milk thistle 2 times a day have bought my ast from 116 to 96 , and alt from 400 to 275 .
PLEASE MY FRIENDS be carefull of what u eat and drink when suffering from hcv ... saying that " its natural " dosent mean its good for us ... we have a specific disease .... mud is natural too - would we eat it !!!
people without liver disease can eat and drink all that they want ..including mud -;) ..... but not us ,
i may be wrong and do welcome ure inputs .
also before i leave - i need to ask u all a small question .
as i said earlier - i was infected ( not diagnosed ) with hcv 3 years ago , do i need to get a live biopsy done !!! i dont drink or eat red meat and oily food , my ultra sound shows no enlargement ... but i am tired and have fatgue all the time .... yes my liver enzimes are high .. but im pretty sure that the reason behind that is the resveratrol and the vit e tablets which i have stopped taking now . .
thanking u and wishing u all well - await ure inputs regarding the bx .. and hope u all find the above studies helpfull.
pacman
I'm sorry that none of us knew this information to warn you away from this problem - but we hadn't heard about it yet which is why you probably didn't get many answers. Sometimes we all feel it's better not to guess at something we aren't sure about and this is something not much of us would know of.
It is amazing how many things people with hep have to be leery off. I didn't take a multi when I was on treatment because the doc said I didn't want extra A or K (in addition to the iron) because they are stored in the liver. Basically I just took the things I knew were ok for me that might help.
Never knew about peanuts and strawberries - I ate a peanut butter and jelly sandwich just about every single day on treatment thinking the fat and the fruit would be good to absorb the riba with healthy natural oils. I guess I'm very lucky to have succeeded.
And remember your liver enzymes will go up and down just like your viral load - granted yours went up a lot but this is really not uncommon. Don't sweat it too much it's not really an indicator of anything that much. Yours undoubtedly jumped from the RVT I would bet you are correct there. The biopsy would definitely be the best way to find out how much liver damage you have but I would think that having the virus only three years with low enzymes all that time it would not be too much. You might find some peace of mind in that fact though and then realize that you do have time to wait for the new drugs to come out and they are downright miraculous it seems.
Thank you for the info about RESVERATROL - that is very very good to be aware of and we'll all try to make sure people realize it's not something that they should mess around with then.
Best of luck, Debby
It is amazing how many things people with hep have to be leery off. I didn't take a multi when I was on treatment because the doc said I didn't want extra A or K (in addition to the iron) because they are stored in the liver. Basically I just took the things I knew were ok for me that might help.
Never knew about peanuts and strawberries - I ate a peanut butter and jelly sandwich just about every single day on treatment thinking the fat and the fruit would be good to absorb the riba with healthy natural oils. I guess I'm very lucky to have succeeded.
And remember your liver enzymes will go up and down just like your viral load - granted yours went up a lot but this is really not uncommon. Don't sweat it too much it's not really an indicator of anything that much. Yours undoubtedly jumped from the RVT I would bet you are correct there. The biopsy would definitely be the best way to find out how much liver damage you have but I would think that having the virus only three years with low enzymes all that time it would not be too much. You might find some peace of mind in that fact though and then realize that you do have time to wait for the new drugs to come out and they are downright miraculous it seems.
Thank you for the info about RESVERATROL - that is very very good to be aware of and we'll all try to make sure people realize it's not something that they should mess around with then.
Best of luck, Debby
Thanks for the info pacman. My mantra is all things in moderation. I have normal liver enzymes and take no supplements or antifibrotics. I eat anythng I want to with in reason and I've found in my quest to battle hepc common sense rules.
Trinity
Trinity
Thanks for the post. I knew vitamin E could build up in your system if you take too much, but had been advised that it was a good anti-aging vitamin for vascular system and skin. Now I'm thinking that maybe I shouldn't worry about anti-aging stuff until I finish tx.
If I were you, I'd get the biopsy, especially since you are having the same symptoms I'm having, and I got infected in the early 80s. It is better to know the facts than to just wonder what is going on.
If I were you, I'd get the biopsy, especially since you are having the same symptoms I'm having, and I got infected in the early 80s. It is better to know the facts than to just wonder what is going on.
Dear Debby , Trinity and Diane , thank you for your kind words and input regarding the bx .
Diane i wonder if my symptoms could be due to clinical depression , i would not like to believe that i have cirossis or fibrosis within 3 years of getting infected .
ive had a realllly tough time while being on the tx , i was put onto the tx withought any anti- deps and nor was i given any platelet boosters even when my platelets fell to 40k , which nearly put me into a coma ..... sadly i dont live in the usa ... where hepatology is a specialized field , unlike in my country .
I am also extremly scared of going in for a bx because ive heard that a lot of people have had bad experiances where their livers have been injured due to the bx ....
could i have fibrosis or cirrosis so soon ...!!! 3 years !!! .. keeping in mind that i dont drink or smoke or eat red meat !!! or could i still be fighting the effects of the tx ...finished tx 2 years ago ...
thanking u again
regards
pacman
Diane i wonder if my symptoms could be due to clinical depression , i would not like to believe that i have cirossis or fibrosis within 3 years of getting infected .
ive had a realllly tough time while being on the tx , i was put onto the tx withought any anti- deps and nor was i given any platelet boosters even when my platelets fell to 40k , which nearly put me into a coma ..... sadly i dont live in the usa ... where hepatology is a specialized field , unlike in my country .
I am also extremly scared of going in for a bx because ive heard that a lot of people have had bad experiances where their livers have been injured due to the bx ....
could i have fibrosis or cirrosis so soon ...!!! 3 years !!! .. keeping in mind that i dont drink or smoke or eat red meat !!! or could i still be fighting the effects of the tx ...finished tx 2 years ago ...
thanking u again
regards
pacman
i could find studies that say resvervatol is good for you, and have read them in the past.
i agree about vit e being bad in excess
i agree about vit e being bad in excess
Hi jusjames , thank you for ure post . yes i too saw a lot of studies stating that resveratrol was amazing for the liver and heart etc ....
but then came across this specific study .. this study is dated jan 2010 and is directly in RELATION TO HEPATITIS C , i have already suffered by drinking grape juice and eating peauts like a nut -:) ...
heres the link again if u like - http://www.ncbi.nlm.nih.gov/pubmed/20066737
take care and wish u well
regards
pacman .
but then came across this specific study .. this study is dated jan 2010 and is directly in RELATION TO HEPATITIS C , i have already suffered by drinking grape juice and eating peauts like a nut -:) ...
heres the link again if u like - http://www.ncbi.nlm.nih.gov/pubmed/20066737
take care and wish u well
regards
pacman .
Thanks for the article. As with all things, each of us must weigh the pro's and con's of what we choose to do. I, myself, will continue to eat my peanut butter, because I like and enjoy it. I will continue to use my Cocopure which contains a small amount of Resveratrol, because I like it. I look at the whole picture and not just what it might do to my liver. My heart is also a part of my body and the Resveratrol is good for my heart, so I weigh it..., little bit bad for my liver, or a little bit good for my heart. You know? Every day, one study says Coffee-bad.. and then, Coffee-good and then, a person gets like, well ??? what am I supposed to do. It sometimes can drive you a bit nuts..., no pun intended!! I'm hoping that I am not coming across like I'm getting on to you for posting this because I'm most certainly not! It's always great to make our decisions with all the applicable information we can gather. Thanks again! Susan400
dont know about this...i was reading your link to the study and it didnt mention how many patients or any other info like age,sex...nothin...wjats up with that./...and its this a govt run site you posted in that link?..something looks fishy too me
When HepatitisResearcher was writing here he was a great proponent of resveratrol along with curcumin for their anti-inflammatory / anti-fibrotic properties. I've taken resveratrol ever since he advised it, so I am a lot dismayed by this study. Now I don't know what to think.
Thanks for posting
dointime
Thanks for posting
dointime
i don't buy it and think it is wrong information. Resveratrol is a great "Proven" supplement.
i also remember HR saying it was one of the key supps he recommends to HCV patients.
i also remember HR saying it was one of the key supps he recommends to HCV patients.
Now this study is the perfect example you cant believe "everyting you read on the web"
show me the money
SPEAK TO ME
"I've been mad for ****-ing years, absolutely years, been over the edge for yonks, been working me buns off for bands..."
"I've always been mad, I know I've been mad, like the
most of us...very hard to explain why you're mad, even if you're not mad..."
show me the money
SPEAK TO ME
"I've been mad for ****-ing years, absolutely years, been over the edge for yonks, been working me buns off for bands..."
"I've always been mad, I know I've been mad, like the
most of us...very hard to explain why you're mad, even if you're not mad..."
MEDICAL PROFESSIONAL
Best thing to actually rread the above paper, it is free in full text to everyone. This paper studies the replication of an artificial HCV construct on cultured hepatocytes, in the presence of various concentrations of Resveratrol. it proves nicely that even high doses of RSV are unlikely to have any effect on HCV replication in vivo in man. How so?
On page 187 Fig 2 you will see the effect of increasing micromols of RSV on fold replication of the HCV construct, readout by the luciferase assay.
On page 188 similarlily in fig 4 the effect on the subgenomic replicon cells. RSV in micromols/Liter vs fold replication enhancement. Good work, we assume.
Now there are a few papers that have actually measured, in a reliable well documented HPLC fashion, the achieved RSV concentration in the blood of human subjects after exposure to 250 and 500mg of 99% transResveratrol. In the paper in the American Journal for Clinical Nutrition , published ahead of print March 31st 2010 you find on the forth page in fig 2 the graph of plasma concentrations of RSV as a function of time in these humans to be dose dependent and having for 500mg (quite a high dose!) found the peak concentration of original RSV at 90min after dosing to be 14.4 nanograms/ml or 14.4 micrograms/liter. Knowing the molecular weight of RSV to be 228g/Mol this translates into 14.4/228 micromolar max achievable concentration ,so approx 0.06 micromolar.
If you place this result in the almost linear dependence of replication enhancement foldness of the above paper (see fig 2 AND 4) you will see that the enhancement at this in vivo micromolarity is somewhere between 1 and 5% of starting value, a totally irrelevant phenomenon, if we take everything at face value. In summary, if we trust both papers, there should be no relevant influence by RSV on HCV replication in vivo in man by doses as high as 500mg.
These papers have to be studies in fine details to arrive at realistic conclusions.
On page 187 Fig 2 you will see the effect of increasing micromols of RSV on fold replication of the HCV construct, readout by the luciferase assay.
On page 188 similarlily in fig 4 the effect on the subgenomic replicon cells. RSV in micromols/Liter vs fold replication enhancement. Good work, we assume.
Now there are a few papers that have actually measured, in a reliable well documented HPLC fashion, the achieved RSV concentration in the blood of human subjects after exposure to 250 and 500mg of 99% transResveratrol. In the paper in the American Journal for Clinical Nutrition , published ahead of print March 31st 2010 you find on the forth page in fig 2 the graph of plasma concentrations of RSV as a function of time in these humans to be dose dependent and having for 500mg (quite a high dose!) found the peak concentration of original RSV at 90min after dosing to be 14.4 nanograms/ml or 14.4 micrograms/liter. Knowing the molecular weight of RSV to be 228g/Mol this translates into 14.4/228 micromolar max achievable concentration ,so approx 0.06 micromolar.
If you place this result in the almost linear dependence of replication enhancement foldness of the above paper (see fig 2 AND 4) you will see that the enhancement at this in vivo micromolarity is somewhere between 1 and 5% of starting value, a totally irrelevant phenomenon, if we take everything at face value. In summary, if we trust both papers, there should be no relevant influence by RSV on HCV replication in vivo in man by doses as high as 500mg.
These papers have to be studies in fine details to arrive at realistic conclusions.
I found this link which contains a good discussion:
http://www.wjgnet.com/1007-9327/16/184.pdf
What I make of it is that HR may have been right about resveratrol's anti-inflammatory and anti-fibrotic properties, however this study does indicate that resveratrol enhances hcv replication. The study makes a point of saying not to use resveratrol along with ifn & riba as it could negate their antiviral effects, which is fair enough.
But for those people not on tx, if resveratrol does indeed protect the liver then who cares about a high viral load. But does it in fact? The study says there is still a debate about it's liver protecting properties.
So, insufficient information. I'll have to mull it over whether I should quit taking it after this.
dointime
http://www.wjgnet.com/1007-9327/16/184.pdf
What I make of it is that HR may have been right about resveratrol's anti-inflammatory and anti-fibrotic properties, however this study does indicate that resveratrol enhances hcv replication. The study makes a point of saying not to use resveratrol along with ifn & riba as it could negate their antiviral effects, which is fair enough.
But for those people not on tx, if resveratrol does indeed protect the liver then who cares about a high viral load. But does it in fact? The study says there is still a debate about it's liver protecting properties.
So, insufficient information. I'll have to mull it over whether I should quit taking it after this.
dointime
Many thanks for weighing in on this. I wrote my last entry before reading yours. As you can see, I wasn't able to arrive at a realistic conclusion by myself so your intervention has been very helpful.
dointime
dointime
its not wrong information,its misinformation the call it.....not a lie or wrong,just mis leading,kind a a white lie in disguise
I've found over and over in life that the best thing is moderation. If you just think about how everything in the universe works, left alone, it will seek balance. Extremes are quickly eliminated. This is just the natural order of things.
I'm pretty sure one can't go wrong following this same advice in all areas of your life, including what you ingest.
I'm pretty sure one can't go wrong following this same advice in all areas of your life, including what you ingest.
HR, nice to see that you stopped by with your expert opinion. Hope you are well. Please stop back once in awhile.
Rocker, once again thanks for your intelligent reply. You always have so much to add to this forum.
Rocker, once again thanks for your intelligent reply. You always have so much to add to this forum.
I was so surprised to see your name. Many thanks for explaining this. I am not capable of understanding the explanation but I get what is important to get...keep giving Joe resveratrol.
You pretty much made my day!
Ev
You pretty much made my day!
Ev
all: pubmed links for the two articles in HR's post are
http://www.ncbi.nlm.nih.gov/pubmed/20066737
http://www.ncbi.nlm.nih.gov/pubmed/20357044
only the 1st (the RVT/HCV one) is free access, but the pubmed-linked pdf seems a bit more legible than one in dointime's link (same content).
HR: always great to see you posting! Point well taken that the concentration at which replication was significantly enhanced in the OR6 and replicon cell lines is much greater than the peak dosage available from ordinary use of RVT as a supplement (from Fig 2 it looks like to get a doubling of HCV rate would require about 8 umol/L, more than 100 times higher than the concentration available from taking a 500mg supplement).
However, the larger question would seem to be why take this particular anti-oxidant if it can (a) promote hcv replication and (b) interfere with ifn/rbv viral suppression . For example why not take astaxanthin, for which they found no HCV enhancing effect? Presumably the answer is RVT's potent anti-fibrotic effects, however their discussion suggests some earlier results have been called into question:
http://www.ncbi.nlm.nih.gov/pubmed/19207580
"Resveratrol amplifies the profibrogenic activation of human hepatic LX-2 stellate cells. "
I have to confess I've let my RVT order lapse, mostly because of cost, but now I'm wondering whether there might be some rationalization for being cheap...
http://www.ncbi.nlm.nih.gov/pubmed/20066737
http://www.ncbi.nlm.nih.gov/pubmed/20357044
only the 1st (the RVT/HCV one) is free access, but the pubmed-linked pdf seems a bit more legible than one in dointime's link (same content).
HR: always great to see you posting! Point well taken that the concentration at which replication was significantly enhanced in the OR6 and replicon cell lines is much greater than the peak dosage available from ordinary use of RVT as a supplement (from Fig 2 it looks like to get a doubling of HCV rate would require about 8 umol/L, more than 100 times higher than the concentration available from taking a 500mg supplement).
However, the larger question would seem to be why take this particular anti-oxidant if it can (a) promote hcv replication and (b) interfere with ifn/rbv viral suppression . For example why not take astaxanthin, for which they found no HCV enhancing effect? Presumably the answer is RVT's potent anti-fibrotic effects, however their discussion suggests some earlier results have been called into question:
http://www.ncbi.nlm.nih.gov/pubmed/19207580
"Resveratrol amplifies the profibrogenic activation of human hepatic LX-2 stellate cells. "
I have to confess I've let my RVT order lapse, mostly because of cost, but now I'm wondering whether there might be some rationalization for being cheap...
Hiya rocker , hope my message finds u in better health and spirit ,
u wrote ....
"dont know about this...i was reading your link to the study and it didnt mention how many patients or any other info like age,sex...nothin...wjats up with that./...and its this a govt run site you posted in that link?..something looks fishy too me"
the answer to that would be - i did the tests at home with a test tube , some of my blood and grape juice and peanuts .... hope thats satisfactory and to ure liking -:) ...
take care and wish u well .
pacman 1372 .
u wrote ....
"dont know about this...i was reading your link to the study and it didnt mention how many patients or any other info like age,sex...nothin...wjats up with that./...and its this a govt run site you posted in that link?..something looks fishy too me"
the answer to that would be - i did the tests at home with a test tube , some of my blood and grape juice and peanuts .... hope thats satisfactory and to ure liking -:) ...
take care and wish u well .
pacman 1372 .
HI alek , i was taking 400 iu of vit e cap + the multi vit tab i was taking had about 50iu in it too ,
what i think ,messed up things for me was the resveratrol , trying to be healthy ... i started drinking grape juice instead of coke ..... big mistake .. it made my alt go from 160 to 400 in one month .... i would have probably been healthier having coke .. lol
take care and all the best
pacman 1372
what i think ,messed up things for me was the resveratrol , trying to be healthy ... i started drinking grape juice instead of coke ..... big mistake .. it made my alt go from 160 to 400 in one month .... i would have probably been healthier having coke .. lol
take care and all the best
pacman 1372
"i started drinking grape juice instead of coke"
--------------------------------
Too funny. You drank a bunch of fructose and you're wondering why your liver enzymes went up. Did you not realize that fructose is bad for your liver?
Your liver enzymes went down when you stopped the RVT and Vit E....yes, but you also stopped the juice at the same time.
"i started juicing with strawberries , black and green grapes, carrots, pomegranade, and some lemon"
---------------------------
Did you check to see if any of those fruits inhibits CYP3A4 and whether that would raise the levels of anything else you're taking? Because I believe pomegranade does.
"yes my liver enzimes are high .. but im pretty sure that the reason behind that is the resveratrol and the vit e tablets which i have stopped taking now"
----------------------------- . .
If you approach something with your mind already made up you will miss much....and you may be wrong...and a bunch of people now believe what you told them.
Co.
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Too funny. You drank a bunch of fructose and you're wondering why your liver enzymes went up. Did you not realize that fructose is bad for your liver?
Your liver enzymes went down when you stopped the RVT and Vit E....yes, but you also stopped the juice at the same time.
"i started juicing with strawberries , black and green grapes, carrots, pomegranade, and some lemon"
---------------------------
Did you check to see if any of those fruits inhibits CYP3A4 and whether that would raise the levels of anything else you're taking? Because I believe pomegranade does.
"yes my liver enzimes are high .. but im pretty sure that the reason behind that is the resveratrol and the vit e tablets which i have stopped taking now"
----------------------------- . .
If you approach something with your mind already made up you will miss much....and you may be wrong...and a bunch of people now believe what you told them.
Co.
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