So I started the Depo shot in October 2010. After a few weeks, I was told I should go in for a check up to the doctor's, but she accidentally gave me another shot of the Depo. I then went in again for my "second" shot of the Depo three months ago, since she just disregarded her mistake of giving me a shot too early. After gaining about 20 pounds, and other complications due to the shot, I decided to go off it. It's really difficult to lose the weight, and I was wondering if there were any suggestions, and how long it takes until the shot leaves your system? Working out 6 days a week vigorously has not worked at all. I heard that a zero-carb diet works, but I am already on a low-carb diet because I am a type 1 diabetic.