I had a small tubular cancer (1mm) removed in a surgical biopsy. I stopped using an HRT patch (on HRT for 6 years) immediately after being diagnosed and had 33 radiation treatments. At about the 2/3 mark of radiation treatments, my joints began to be sore. At the end of radiation, I sprained my knee walking across the street. I have two autoimmune diseases which could contribute to joint pain and/or connective tissue issues--Primary Biliary Cirrhosis and Sjogren's Syndrome. It has been two weeks since my knee injury and I am still unable to walk without pain. Muscles in both legs ache and my shoulders, elbows, and fingers are sore upon waking in the morning. Are the joint pains and injury more likely to be a result of the stress of radiation therapy or could they be from stopping HRT cold turkey? I have never had such pain before.