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Side effects often occur at the beginning of treatment then wear off as your body gets used to the medicine. However, there are other oral anti-biotics which may suit you better such as oxytetracycline or erythromycin. Accutane is a retinoid, and not related to anti-biotics so the side effects are different. However, the list of potential rare side effects of accutane is long and includes headaches, nausea, muscle pain and depression. More commonly, the main side effect is dry lips and skin. With any medication, the expected benefit of treatment must outweigh the potential side effects for it to be worth it. Loiloi x