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Drug Tolerance
by ginsa, Sep 01, 2009 02:31PM
Hi all,
Some time ago I read that opiate use creates more receptors and that is partially what leads to building tolerance to higher doses. I have been all over the web trying to find this information again. I thought I read it in the Health Pages on this list, but not sure. There seems to be a lot of confusion about the mechanics? of tolerance. I'd really appreciate help in finding more about this.
Thanks,
Ginsa
Some time ago I read that opiate use creates more receptors and that is partially what leads to building tolerance to higher doses. I have been all over the web trying to find this information again. I thought I read it in the Health Pages on this list, but not sure. There seems to be a lot of confusion about the mechanics? of tolerance. I'd really appreciate help in finding more about this.
Thanks,
Ginsa
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avis
Strong pain is so stimulating itself that dependence when treating strong pain is rare. These mechanisms result from changes in nervous system receptors in response to the drug. In response to the drug, the brain creates new receptors for opiates. These receptors are "pseudo" receptors and do not work. When the opiates are out of the body, the brain has more receptors than before the use of the drug, but only the same amount of endogenus opiates ( endorphines) to fill these receptors. This is why opiate addiction is different from other addictions and also the reason for the fast building tolerance for the drug. (The brain needs more and more drugs to achieve the same effects.)
http://www.economicexpert.com/a/Opium.htm