It is uncommon to find granulomas in the bone marrow. When we do see them, there can be many different potential causes including: various types of infection, autoimmune diseases, medications, or malignancies.
In the majority of patients, MGUS (monoclonal gammopathy of undetermined significance) is a benign condition, but in some it can progress to a cancer called multiple myeloma. There is no treatment for it, but it should be monitored. MGUS can also be present in patients who have other autoimmune or chronic inflammatory conditions.
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