IHC/FISH test

Hello,

I have had two IHC tests. The first test my doctor described as having Her2 traces and asked for a the second which was Her2 3+.

In order to qualfiy for a clinical trial a FISH test had to be done and it came back negative.

From what I have read this rarely happens with a IHC 3+ result.

I would be very grateful if you could advise as to what my Her2 status actually is.

Regards Maggiec

[CCF-RN,MSN-rf]

Dear Maggiec: There are two main ways to test Her-2/neu status: immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH). IHC measures the amount of Her-2/neu protein present. FISH looks at the genetic level for actual gene amplification

[maggiec]

Thank you so much for your reply. I have asked my oncologist about a re-test but he said the FISH report is very detailed and he has every confidence it is accurate. I hope he is right but will ask him again.

Again many thanks

[deedee1950]

A related discussion, IHC and FISH was started.